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Fludarabine
drug data and news
Fludarabine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Fludarabine | ||
| Brand Names/Synonyms | FAMP; Fludara; Fludarabine; Fludarabine 5'-Monophosphate; Fludarabine Monophosphate; Fludarabine Phosphate; Fludarabine Phosphate [Usan:Ban]; Fludura | ||
| Indication | For the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to or whose disease has progressed during treatment with at least one standard alkylating-agent containing regimen | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Fludarabine is a chemotherapy drug used in the treatment of chronic lymphocytic leukemia. It acts at DNA polymerase alpha, ribonucleotide reductase and DNA primase, results in the inhibition of DNA synthesis, and destroys the cancer cells. | ||
| Mechanism Of Action | Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite appears to act by inhibiting DNA polymerase alpha, ribonucleotide reductase and DNA primase, thus inhibiting DNA synthesis. The mechanism of action of this antimetabolite is not completely characterized and may be multi-faceted. | ||
| Fludarabine News (When available) |
CV Therapeutics' Ranexa May Have Trouble Meeting Street Targets Mar 2, 2006 CV Therapeutics Reports 2005 Fourth Quarter and Full Year ... Mar 1, 2006 CV Therapeutics Reports Option Grants Under Nasdaq Marketplace ... Feb 28, 2006 CV Therapeutics fourth-quarter loss widens Mar 1, 2006 CV Therapeutics Announces Four Abstracts Accepted for Presentation ... Mar 3, 2006 UPDATE 1-CV Therapeutics 4th-quarter loss widens Mar 1, 2006 CV Therapeutics Announces MERLIN TIMI-36 Study to Continue as ... 09 Feb 2006 FDA Approves Ranexa Jan 27, 2006 CV Therapeutics Appoints Joseph M. Davie, MD, Ph.D. to Board of ... Jan 13, 2006 CV Therapeutics Gets FDA OK To Sell Ranexa In Angina Jan 30, 2006 Caldwell: An update on Veterans' benefits Dec 7, 2005 CV Therapeutics May See Strong Ranexa Potential Nov 17, 2005 Data From Evaluation of Ranolazine in Chronic Angina (ERICA) Study ... Nov 16, 2005 New Ascot-BPLA Substudy Shows Coversyl's Cardioprotective Benefits ... Nov 14, 2005 Coversyl's Cardioprotective Benefits Go Beyond Blood Pressure ... Nov 25, 2005 CV Therapeutics Reports Option Grants Under Nasdaq Marketplace ... Sep 15, 2005 Regadenoson Phase 3 Data Presented as Late-Breaker at American ... Oct 2, 2005 Obama against review of stress disorder cases Oct 2, 2005 Analysis: Blood-pressure guideline blurred Sep 16, 2005 Two New Treatment Advances For Coronary Artery Disease Patients Sep 11, 2005 New Hope For Elderly Heart Attack Survivors Sep 11, 2005 Amlodipine-Based Regimen Better Than Atenolol for Hypertension Sep 9, 2005 | ||
| Dosage Forms | TABLET; POWDER FOR SOLUTION; IV Solution | ||
| Drug_Category | Immunosuppressive Agents; Antimetabolites; Antineoplastic Agents; ATC:L01BB05 | ||
| Absorption | Not Available | ||
| Interactions |
Interactions for Fludarabine: The use of FLUDARA FOR INJECTION in combination with pentostatin is not recommended due to the risk of severe pulmonary toxicity. | ||
| Toxicity | Not Available | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | [5-(6-amino-2-fluoro-purin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxyphosphonic acid | ||
| Chemical Formula | C10H13FN5O7P | ||
| Molecular Weight | 365.212 g/mol | ||
| Smiles String | C1=NC2=C(N1C3C(C(C(O3)COP(=O)(O)O)O)O)N=C(N=C2N)F | ||
| Melting Point | 260 °C | ||
| Water Solubility | 3.53 mg/ml | ||
| State | Solid | ||
| LogP/Hphobicity | -0.852 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Not Available | ||
| Half Life | 20 hours | ||
| Protein Binding [%] | 19-29% | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Fludarabine.html http://www.rxlist.com/cgi/generic/fludarabine.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00594 | ||
| CAS Registry Number | 75607-67-9 | ||
| KEGG Compound ID | C13380 | ||
| PubChem ID | SID:338239 | ||
| PharmGKB ID | PA449655 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2246226 |
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