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Flucloxacillin
drug data and news
Flucloxacillin drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Flucloxacillin | ||
| Brand Names/Synonyms | BRL 2039; FLOXACILLIN; Floxacillin; Floxacillin [Usan]; Floxapen; Fluclox; Flucloxacilina [Inn-Spanish]; Flucloxacillin; Flucloxacillin Sodium; Flucloxacillin-Sodium; Flucloxacilline [Inn-French]; Flucloxacillinum [Inn-Latin]; Sesamol | ||
| Indication | For bacterial infection | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Flucloxacillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Flucloxacillin has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Flucloxacillin results from the inhibition of cell wall synthesis and is mediated through Flucloxacillin binding to penicillin binding proteins (PBPs). Flucloxacillin is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases. | ||
| Mechanism Of Action | By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Flucloxacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Flucloxacillin interferes with an autolysin inhibitor. | ||
| Flucloxacillin News (When available) |
Superbug: QE Nation's Worst ; HEALTH: League Tables Damning for ... Feb 7, 2006 | ||
| Dosage Forms | LIQUID | ||
| Drug_Category | Anti-bacterial Agents; Penicillins; ATC:J01CF05 | ||
| Absorption | Not Available | ||
| Interactions | Not Available | ||
| Toxicity | Not Available | ||
| Organisms Affected | Enteric bacteria and other eubacteria | ||
| Chemical IUPAC Name | 7-[3-(2-chloro-6-fluoro-phenyl)-5-methyl-oxazol-4-yl]carbonylamino-3,3-dimethyl-6-oxo-2-thia-5-azabicyclo[3.2.0]heptane-4-carboxylicacid | ||
| Chemical Formula | C19H17ClFN3O5S | ||
| Molecular Weight | 453.873 g/mol | ||
| Smiles String | CC1=C(C(=NO1)C2=C(C=CC=C2Cl)F)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)O | ||
| Melting Point | Not Available | ||
| Water Solubility | Not Available | ||
| State | Solid | ||
| LogP/Hphobicity | Not Available | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Not Available | ||
| Half Life | Not Available | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | Not Available>RXlist | ||
| Sponsored links | |||
| Drug Reference | http://www.drugs.com/cons/Flucloxacillin.html | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00609 | ||
| CAS Registry Number | 5250-39-5 | ||
| KEGG Compound ID | C11748 | ||
| PubChem ID | SID:13913 | ||
| PharmGKB ID | PA10266 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 525561 |
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