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Floxuridine
drug data and news
Floxuridine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Floxuridine | ||
| Brand Names/Synonyms | 5 Fluorodeoxyuridine; 5fdu; Deoxyfluorouridine; FDUR; FUDR; Fdurd; Floxiridina [Inn-Spanish]; Floxuridin; Floxuridine; Floxuridine [Usan:Inn]; Floxuridinum [Inn-Latin]; Fluorodeoxyuridine; Fluoruridine Deoxyribose; HSDB 3227; NSC 27640; NSC-26740; NSC-27640 | ||
| Indication | For palliative management of gastrointestinal adenocarcinoma metastatic to the liver, when given by continuous regional intra-arterial infusion in carefully selected patients who are considered incurable by surgery or other means. | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Floxuridine is a pyrimidine analog that acts as an inhibitor of the S-phase of cell division. This selectively kills rapidly dividing cells. Floxuridine is an anti-metabolite. Anti-metabolites masquerade as pyramidine-like molecules which prevents normal pyrimidines from being incorporated into DNA during the S phase of the cell cycle. Flurouracil (the end-product of catabolism of floxuridine) blacks an enzyme which converts cytosine nucleosides into the deoxy derivative. In addition, DNA synthesis is further inhibited because fluoruracil blocks the incorporation of the thymdine nucleotide into the DNA strand. | ||
| Mechanism Of Action | Floxuridine is rapidly catabolized to 5-fluorouracil which is the active form of the drug. Fluorouracil inhibits thymydilate synthase leading to inhibition of DNA synthesis, RNA synthesis and cell death. | ||
| Floxuridine News (When available) |
Cancerpage.com, NEW YORK DEC 05, 2005 (Reuters Health) - Adding high-dose conformal radiation therapy (RT) to intra-arterial floxuridine improves outcomes in patients with ... Radiation can help when liver cancer is inoperable Dec 5, 2005 ABC News Ben-Josef and colleagues treated 128 patients with inoperable liver cancer with high-dose radiation therapy and infusion of the chemo agent floxuridine into an ... Bile duct cancer, liver cancer, or metastatic colorectal cancer ... Dec 3, 2005 Xagena.it, In the study, patients received radiation twice daily for two weeks, along with a continuous infusion of the chemotherapy drug Floxuridine ( FUDR ). ... | ||
| Dosage Forms | POWDER FOR SOLUTION (500mg vial) | ||
| Drug_Category | Antivirals; Antimetabolites | ||
| Absorption | Not Available | ||
| Interactions | Interactions for Floxuridine: Combination Therapy: Any form of therapy which adds to the stress of the patient, interferes with nutrition or depresses bone marrow function will increase the toxicity of Floxuridine. | ||
| Toxicity | Oral, rat LD50: 215 mg/kg. Signs of overdose include nausea, vomiting, diarrhea, gastrointestinal ulceration and bleeding, and bone marrow depression (including thrombocytopenia, leukopenia and agranulocytosis). | ||
| Organisms Affected | Not Available | ||
| Chemical IUPAC Name | 5-fluoro-1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1H-pyrimidine-2,4-dione | ||
| Chemical Formula | C9H11FN2O5 | ||
| Molecular Weight | 246.193 g/mol | ||
| Smiles String | C1C(C(OC1N2C=C(C(=O)NC2=O)F)CO)O | ||
| Melting Point | 150.5 °C | ||
| Water Solubility | 1.19E+004 mg/L | ||
| State | Solid (white powder) | ||
| LogP/Hphobicity | -1.249 | ||
| Isoelectric Point | 7.44 | ||
| Biotransformation | Hepatic. | ||
| Half Life | Not Available | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Floxuridine.html http://www.rxlist.com/cgi/generic2/floxuridine.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00692 | ||
| CAS Registry Number | 50-91-9 | ||
| KEGG Compound ID | C11736 | ||
| PubChem ID | SID:148580 | ||
| PharmGKB ID | PA449652 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | Not Available |
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