|
|
|
|
|
Filgrastim
drug data and news
Filgrastim drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
|
| Generic name | Filgrastim | ||
| Brand Names/Synonyms | Granulocyte colony-stimulating factor precursor;G-CSF;Pluripoietin;Filgrastim;Lenograstim; Neupogen (Amgen Inc.) | ||
| Indication | Increases leukocyte production, for treatment in non-myeloid cancer,neutropenia and bone marrow transplant | ||
| Sponsored links | Description | Recombinant human G-CSF (Granulocyte colony stimulating factor), 175 residues, expressed in E. coli. The protein has an amino acid sequence that is identical to the natural sequence predicted from human DNA sequence analysis, except for the addition of an N-terminal methionine necessary for expression in E coli. | |
| Pharmacology | Used in the treatment of chemotherapy-induced neutropenia by enhancing the production of neutrophils. Filgrastim acts on hematopoietic cells by binding to specific cell surface receptors thereby stimulating proliferation, differentiation, commitment, and end cell functional activation. | ||
| Mechanism Of Action | Filgrastim binds to the G-CSF receptor. As a G-CSF analog, it controls proliferation of committed progenitor cells and influences their maturation into mature neutrophils. Filgrastim also stimulates the release of neutrophils from bone marrow storage pools and reduces their maturation time. Filgrastim acts to increase the phagocytic activity of mature neutrophils. In patients receiving cytotoxic chemotherapy, Filgrastim can accelerate neutrophil recovery, leading to a reduction in duration of the neutropenic phase | ||
| Filgrastim News (When available) |
America Readies for the Worst Mar 3, 2006 Health: More Asian Pacific Islanders Needed For Marrow Donations Feb 15, 2006 Croatia's Pliva, Australia's Mayne end erythropoietin development ... Feb 22, 2006 Intensive Therapy May Benefit Women With Breast Cancer of a Poor ... Feb 14, 2006 Sequential High-Dose Chemotherapy with Stem Cell Support Promising ... Feb 13, 2006 Amgen Continues Manufacturing Expansion with Additional $1 Billion ... Feb 2, 2006 | ||
| Dosage Forms | SOLUTION | ||
| Drug_Category | Immunomodulatory Agents; Anti-infective Agents; Antineutropenic Agents; hematopoietic agents (20:16.00) | ||
| Absorption | Not Available | ||
| Interactions | Not Available | ||
| Toxicity | Not Available | ||
| Organisms Affected | Not Available | ||
| Chemical IUPAC Name | Human granulocyte colony stimulating factor | ||
| Chemical Formula | C845H1343N223O243S9 | ||
| Molecular Weight | 18802.8 | ||
| Smiles String | Not Available | ||
| Melting Point | 60 oC (Luo, P., Protein Science 11:1218-1226 (2002)) | ||
| Water Solubility | Not Available | ||
| State | Transparent, slightly viscous, aqueous liquid | ||
| LogP/Hphobicity | 0.209 | ||
| Isoelectric Point | 5.65 | ||
| Biotransformation | Not Available | ||
| Half Life | Not Available | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Filgrastim.html http://www.rxlist.com/cgi/generic/filgrastim.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | BIOD00072 | ||
| CAS Registry Number | 143011-72-7 | ||
| KEGG Compound ID | Not Available | ||
| PubChem ID | Not Available | ||
| PharmGKB ID | PA449626 | ||
| SwissProt ID | CSF3_HUMAN (P09919) | ||
| GenBank ID | X03438 | ||
| Drug ID Number [DIN] | 1968017 |
|
Home | About | Cancers | Treatment | Medications Copyright onconews.org 2005. All Rights Reserved. |