Fenfluramine drug data and news

Fenfluramine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name Fenfluramine
Brand Names/Synonyms Acino; Adipomin; CHEMBANK1560; Dea No. 1670; F1884; Fenfluramina [Dcit]; Fenfluramine; Fenfluramine Hydrochloride; Fenfluraminum [Inn-Latin]; HSDB 3080; Obedrex; Pesos; Ponderax Pa; Ponderex; Pondimin; Rotondin; S 768
Indication For the management of exogenous obesity as a short-term (a few weeks) adjunct in a regimen of weight reduction based on caloric restriction.
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Description Not Available
Pharmacology Used to treat diabetes and obesity, Fenfluramine decreases caloric intake by increasing serotonin levels in the brain’s synapses. Fenfluramine acts as a serotonin reuptake inhibitor. It also causes release of serotonin from the synaptosomes.
Mechanism Of Action Fenfluramine binds to the serotonin reuptake pump. This causes inhbition of serotonin uptake and release of serotonin. The increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates.
Fenfluramine News
(When available)

Combined, Genes and Environment Affect Health More Than They Do ...  06 Mar 2006
...such as olanzapine, can produce significant weight gain and diabetes, while drugs that stimulate serotonergic neurons, such as fenfluramine, can induce weight ... - Innovations-Report,

Mechanically stimulating the heart  Feb 23, 2006
Her team is also looking into what causes the thickening of valves in the presence of fenfluramine, one of the drugs used in the banned diet drug combo Fen-Phen ... - myDNA.com,

Ky. Judge Resigns After Fen-Phen Reprimand  Feb 27, 2006
The fenfluramine half of fen-phen was pulled from the market in September 1997 by drugmaker Wyeth amid reports some users had heart valve damage and a few had ... - Houston Chronicle,

Kentucky judge resigns after public reprimand  Feb 28, 2006
Fen-phen became the diet craze of the 1990s when researchers found that when mixed together, two appetite suppressants, fenfluramine and phentermine, caused ... - Louisville Courier-Journal,

Judge resigns amid accusations he profited from diet drug case  Feb 27, 2006
The fenfluramine half of fen-phen was pulled from the market in September 1997 by drug maker Wyeth amid reports some users had heart valve damage and a few had ... - Kentucky.com,

There's still no magic pill for weight loss  Feb 19, 2006
Some say the field remains shaken by the FDA's decision to pull fenfluramine and dexfenfluramine from the market in 1997. The combination ... - Boston Globe,

Food firms seek diet bonanza  Feb 19, 2006
Early explorers of the idea were makers of caffeine supplements and pharmaceuticals, such as diet pills Dexatrim and the Fenfluramine-phentermine combination. ... - Arkansas Democrat-Gazette (subscription),

Leading Doctor Cites Obesity Drugs in Attack on FDA Approval ...  Feb 8, 2006
A leading physician, writing in one of the world's most influential medical journals, cited the 1990s diet drug fenfluramine and the new anti-obesity drug ... - Diet Drug Report,

Experimental Obesity Drug APD356 Reported Effective in Small ...  Feb 8, 2006
The new pill thus bears some similarities to the diet combination of fenfluramine and phentermine (fen-phen), in that fenfluramine also worked by increasing ... - Diet Drug Report,

Food makers hunt for next big fad in dieting  Feb 19, 2006
Fen phen, a combination of two diet drugs, ran into trouble when Fenfluramine - the "fen" half of the combination - was withdrawn from the market in 1997 after ... - Bradenton Herald,

Acomplia could break the diet pill curse  Feb 12, 2006
...for decades. The combination of fenfluramine and phentermine ("fen-phen") seemed to work better than either drug alone. The only ... - Houston Chronicle,

Wyeth Hoping to Settle Most Remaining "Fen-phen" Lawsuits in Next ...  Feb 9, 2006
Pondimin (fenfluramine hydrochloride) and Redux (dexfenfluramine), the two drugs that made up the "fen" portion of what in the 1990s was the extraordinarily ... - Diet Drug Report,

Researchers Take Aim At The Causes Of Heart Valve Disease  Jan 31, 2006
...another experiment, Grande-Allen hopes to recreate the process that causes thick, calloused plaques to form on valves in the presence of fenfluramine, one of ... - Medical News Today (press release),

Dosage Forms TABLET
Drug_Category Serotonin reuptake inhibitor; Anorexigenic Agents; Stimulants; ATC:A08AA02; ATC:A08AA04
Absorption Not Available
Interactions Interactions for Fenfluramine:

Fenfluramine may increase slightly the effect of antihypertensive drugs, e.g., guanethidine, methyldopa, reserpine.

Other CNS depressant drugs should be used with caution in patients taking fenfluramine, since the effects may be additive.

Toxicity Not Available
Organisms Affected Humans and other mammals
Chemical IUPAC Name N-ethyl-1-[3-(trifluoromethyl)phenyl]-propan-2-amine
Chemical Formula C12H16F3N
Molecular Weight 231.257 g/mol
Smiles String CCNC(C)CC1=CC(=CC=C1)C(F)(F)F
Melting Point 108-112 oC at 1.20E+01 mm Hg
Water Solubility 412 mg/L
State Liquid
LogP/Hphobicity 3.74
Isoelectric Point Not Available
Biotransformation Not Available
Half Life 20 hours
Protein Binding [%] Not Available
RxList Link RXlist
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Drug Reference http://www.rxlist.com/cgi/generic/fenflur.htm
Drug Type Approved Drug
Accession No APRD00319
CAS Registry Number 458-24-2
KEGG Compound ID C06996
PubChem ID SID:278393
PharmGKB ID PA449592
SwissProt ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] http://www.hc-sc.gc.ca/drug2/dc/product/p12678.html

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