Factor IX drug data and news

Factor IX drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name

Factor IX

Brand Names/Synonyms

Coagulation factor IX precursor;Christmas factor;Plasma thromboplastin component;PTC; Benefix (Genetics Institute)

Indication

For treatment of hemophilia (Christmas diseae)

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Description

Human Factor IX protein, produced by recombinant DNA technology for use in therapy of factor IX deficiency, known as hemophilia B or Christmas disease. Coagulation Factor IX (Recombinant) is a glycoprotein with an approximate molecular mass of 55,000 Da consisting of 415 amino acids in a single chain. It has a primary amino acid sequence that is identical to the Ala 148 allelic form of plasma-derived factor IX.

Pharmacology

Binds vitamin K and factor VIIIa. Cleaves the Arg-Ile bond in factor X to form active factor Xa. Plays a key role in blood coagulation and clotting. Injections of factor IX are used to treat hemophilia B, which is sometimes called Christmas disease. AlphaNine is injected to increase plasma levels of Factor IX and can temporarily correct this coagulation defect.

Mechanism Of Action

Cleaves the Arg-Ile bond in Factor X to form active factor Xa leading to coagulation and clotting.

Factor IX News
(When available)

Biosante wins $250,000 research contract Feb 22, 2006
...has been awarded a $250,000 (€210,000) subcontract from the University of Nebraska, Lincoln (UNL), to develop recombinant Factor IX (FIX) formulations for ... - In-PharmaTechnologist.com,

3rd Generation Andretti Will Race at Indianapolis 500 to Support ... Feb 22, 2006
...is either deficient or defective. Hemophilia B is characterized by deficient or defective factor IX. Bayer HealthCare, a subgroup ... - Genetic Engineering News,

Premier's New Plasma and Recombinant Program Helps Hospitals ... Feb 26, 2006
...include albumin; intravenous immunoglobulin (IVIG); hyperimmune globulin; various coagulation factor products including Factor VIII and Factor IX; alpha-1 ... - dBusinessNews Charlotte (press release),

Research Highlights Feb 22, 2006
Children's Hospital of Philadelphia, Pennsylvania, and her team injected sufferers with a modified virus carrying the gene for blood coagulation factor IX (F.IX ... - Nature.com (subscription),

BioSante Pharmaceuticals Announces Subcontract with the University ... Feb 6, 2006
...(AMEX:BPA) today announced that BioSante has been awarded a subcontract valued at $250,000 for the development of recombinant Factor IX (FIX) formulations for ... - Genetic Engineering News,

Dosage Forms

LIQUID;POWDER FOR SOLUTION

Drug_Category

Coagulants; Thrombotic Agents; hemostatics (20:12.16)

Absorption

Not Available

Interactions

Not Available

Toxicity

Not Available

Organisms Affected

Humans and other mammals

Chemical IUPAC Name

Human factor IX protein

Chemical Formula

C2041H3136N558O641S25

Molecular Weight

46548.2

Smiles String

Not Available

Melting Point

54 oC (Link, R.P., Castellino, F.J. Arch. Biochem. Biophsy. 227:259-265 (1983))

Water Solubility

Not Available

State

Transparent, slightly viscous, aqueous liquid

LogP/Hphobicity

-0.431

Isoelectric Point

5.2

Biotransformation

Not Available

Half Life

17 to 32 hrs

Protein Binding [%]

Not Available

RxList Link

RXlist

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Drug Reference

http://www.drugs.com/cons/Factor_IX.html
http://www.rxlist.com/cgi/generic2/factorix.htm

Drug Type

Approved Drug

Accession No

BIOD00038

CAS Registry Number

9001-28-9

KEGG Compound ID

Not Available

PubChem ID

Not Available

PharmGKB ID

PA449581

SwissProt ID

FA9_HUMAN (P00740)

GenBank ID

K02402

Drug ID Number [DIN]

2228998