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Etoposide
drug data and news
Etoposide drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Etoposide | ||
| Brand Names/Synonyms | Etopophos; Etopophos Preservative Free; Etoposide; Etoposide Usp26; Etoposidum [Inn-Latin]; Lastet; Teniposide; Toposar; Trans-Etoposide; VP-16; Vepesid; Vepesid J; Zuyeyidal | ||
| Indication | For management of refractory testicular tumors and small cell lung carcinoma. Also used to treat brain tumours, cervical cancer, hepatoma, acute myeloid leukemia, acute lymphocity leukemia, karposi’s sarcoma, Wilm’s tumor, head and neck cancer and neuroblastoma | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Etoposide is an antineoplastic agent indicated in the treatment of various cancers. Etoposide is a semisynthetic derivative of the podophyllotoxins, an epipodophyllotoxin. It inhibits DNA topoisomerase II, thereby inhibiting DNA synthesis. Etoposide is cell cycle dependent and phase specific, affecting mainly the S and G2 phases. Two different dose-dependent responses are seen. At high concentrations (10 µg/mL or more), lysis of cells entering mitosis is observed. At low concentrations (0.3 to 10 µg/mL), cells are inhibited from entering prophase. It does not interfere with microtubular assembly. The predominant macromolecular effect of etoposide appears to be the induction of DNA strand breaks by an interaction with DNA-topoisomerase II or the formation of free radicals. | ||
| Mechanism Of Action | Etoposide is a semisynthetic derivative of the podophyllotoxins, an epipodophyllotoxin. Etoposide inhibits DNA topoisomerase II, thereby inhibiting DNA synthesis. Etoposide is cell cycle dependent and phase specific, affecting mainly the S and G2 phases | ||
| Etoposide News (When available) |
Hycamtin® More Convenient than Etoposide in Small Cell Lung ... May 5, 2006 Camptosar®/Carboplatin Improves Progression-Free Survival over ... Apr 21, 2006 Inhibiting cell process may give cancer drug a boost May 3, 2006 Rituxan® Improves Outcomes of Young Patients with Good-Prognosis ... May 1, 2006 Lung cancer CPT-11/SN-38 resistance marked by ABCG2 expression Apr 20, 2006 Survival Improving for Patients with Stage IV Follicular Lymphoma Apr 17, 2006 | ||
| Dosage Forms | SOLUTION; CAPSULE; LIQUID | ||
| Drug_Category | Antineoplastic Agents; ATC:L01CB01 | ||
| Absorption | Absorbed well, time to peak plasma concentration is 1-1.5 hrs | ||
| Interactions |
Interactions for Etoposide: Caution should be exercised when administering ETOPOPHOS with drugs that are known to inhibit phosphatase activities (e.g., levamisole hydrochloride). High-dose cyclosporin A resulting in concentrations above 2000 ng/mL administered with oral etoposide has led to an 80% increase in etoposide exposure with a 38% decrease in total body clearance of etoposide compared to etoposide alone. | ||
| Toxicity | Side effects include alopecia, constipation, diarrhea, nausea and vomiting and secondary malignancies (leukemia) | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl | ||
| Chemical Formula | C29H32O13 | ||
| Molecular Weight | 588.557 g/mol | ||
| Smiles String | CC1OCC2C(O1)C(C(C(O2)OC3C4COC(=O)C4C(C5=CC6=C(C=C35)OCO6)C7=CC(=C(C(=C7)OC)O)OC)O)O | ||
| Melting Point | 236-251 °C | ||
| Water Solubility | 58.7 mg/L | ||
| State | Solid | ||
| LogP/Hphobicity | 1.285 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Primarily hepatic with 40% excreted unchanged in the urine | ||
| Half Life | 4-11 hours | ||
| Protein Binding [%] | 97% | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Etoposide.html http://www.rxlist.com/cgi/generic2/etopophos.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00239 | ||
| CAS Registry Number | 33419-42-0 | ||
| KEGG Compound ID | C01576 | ||
| PubChem ID | SID:177966 | ||
| PharmGKB ID | PA449552 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2241182 |
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