Etoposide drug data and news

Etoposide drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name Etoposide
Brand Names/Synonyms Etopophos; Etopophos Preservative Free; Etoposide; Etoposide Usp26; Etoposidum [Inn-Latin]; Lastet; Teniposide; Toposar; Trans-Etoposide; VP-16; Vepesid; Vepesid J; Zuyeyidal
Indication For management of refractory testicular tumors and small cell lung carcinoma. Also used to treat brain tumours, cervical cancer, hepatoma, acute myeloid leukemia, acute lymphocity leukemia, karposi’s sarcoma, Wilm’s tumor, head and neck cancer and neuroblastoma
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Description Not Available
Pharmacology Etoposide is an antineoplastic agent indicated in the treatment of various cancers. Etoposide is a semisynthetic derivative of the podophyllotoxins, an epipodophyllotoxin. It inhibits DNA topoisomerase II, thereby inhibiting DNA synthesis. Etoposide is cell cycle dependent and phase specific, affecting mainly the S and G2 phases. Two different dose-dependent responses are seen. At high concentrations (10 µg/mL or more), lysis of cells entering mitosis is observed. At low concentrations (0.3 to 10 µg/mL), cells are inhibited from entering prophase. It does not interfere with microtubular assembly. The predominant macromolecular effect of etoposide appears to be the induction of DNA strand breaks by an interaction with DNA-topoisomerase II or the formation of free radicals.
Mechanism Of Action Etoposide is a semisynthetic derivative of the podophyllotoxins, an epipodophyllotoxin. Etoposide inhibits DNA topoisomerase II, thereby inhibiting DNA synthesis. Etoposide is cell cycle dependent and phase specific, affecting mainly the S and G2 phases
Etoposide News
(When available)

Hycamtin® More Convenient than Etoposide in Small Cell Lung ...  May 5, 2006
...agent cisplatin (Platinol®) produce nearly equivalent outcomes with increased convenience compared to the intravenous form of etoposide (VePesid®) plus ... - Cancer Consultants (press release),

Camptosar®/Carboplatin Improves Progression-Free Survival over ...  Apr 21, 2006
...of Camptosar® (irinotecan) plus Paraplatin® (carboplatin) appears to improve progression-free survival compared with VePesid® (etoposide) plus carboplatin ... - Cancer Consultants (press release),

Inhibiting cell process may give cancer drug a boost  May 3, 2006
In addition, treatment with ML-7 in combination with etoposide, a chemotherapy drug used to treat solid tumors, enhanced the ability of etoposide to kill ... - News-Medical.net,

Rituxan® Improves Outcomes of Young Patients with Good-Prognosis ...  May 1, 2006
Four chemotherapy regimens were included: CHOP-21, CHOEP-21 (added etoposide), MACOP-B (cyclophosphamide, doxorubicin, methotrexate, oncovin, bleomycin, and ... - Cancer Consultants (press release),

Lung cancer CPT-11/SN-38 resistance marked by ABCG2 expression  Apr 20, 2006
..."Because H23/SN-38 cells show cross resistance to certain anticancer drugs, such as topotecan, etoposide, doxorubicin and mitoxantrone, ... - Therapeutics Daily (subscription) (press release),

Survival Improving for Patients with Stage IV Follicular Lymphoma  Apr 17, 2006
The third protocol evaluated alternating non-cross resistant regimes with the addition of etoposide, cytarabine, cisplatin and mitoxantrone, the fourth added ... - Cancer Consultants (press release), m/releases/2005/12/051213225424.htm" >National Study Improves Outcome For Pediatric Acute Myeloid ...  Dec 14, 2005
Science Daily (press release) ...multi-center AML02 trial randomly assigns patients to receive either high- or low-dose treatment with cytarabine (A), daunorubicin (D), and etoposide (E) as ...

Age Makes Little Difference in Outcomes for Non-Hodgkin's Lymphoma ...  Dec 12, 2005
DG News ...who relapsed and underwent autologous stem cell transplant following BEAM conditioning, which combines BCNU (carmustine), etoposide, cytosine arabinoside, and ...

Tandem High-Dose Chemotherapy Superior to Dose-Dense Chemotherapy ...  Dec 5, 2005
Cancer Consultants (press release), Following 2 cycles of EP, patients in the tandem transplant arm received 2 cycles of high-dose etoposide, cyclophosphamide and thiotepa with stem cell support. ...

Patients With Unfavorable Risk Hodgkin’s Lymphoma May Not ...  Dec 19, 2005
Cancer Consultants (press release), BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, prednisone) is a more intensive regimen which has also been evaluated ...

Patients with Unfavorable Risk Hodgkin’s Lymphoma May Not ...  Dec 20, 2005
Cancer Consultants (press release), BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone) is a more intensive regimen that has also been ...

ASH: Oral Targeted Agent Boosts Remissions in Poor-Prognosis AML  Dec 14, 2005
MedPage Today, Patients whose remissions lasted one to six months received the MEC regimen (consisting of mitoxantrone, etoposide, and cytarabine), while those whose ...

Intensive Chemotherapy Regimen Shows Promise for Germ Cell Tumors  Dec 5, 2005
Cancer Consultants (press release), ...of cisplatin, vincristine, bleomycin, and carboplatin, followed by one cycle of vincristin and bleomycin and three cycles of bleomycon, etoposide, and cisplatin ...

Induction Chemotherapy and Concomitant Chemoradiotherapy Promising ...  Dec 6, 2005
Cancer Consultants (press release), ...gemcitabine and vinorelbine. This was followed by oral etoposide and cisplatin given concurrently with radiation therapy. 29 patients ...

BiovaxID Vaccine Therapy Of Follicular Lymphoma In First Remission ...  Dec 4, 2005
Medical News Today (press release), ...non-Hodgkin's lymphoma are being treated with BiovaxID immunotherapy following PACE [Prednisone, Doxorubicin, Cyclophosphamide, and Etoposide (ProMACE without ...

Dosage Forms SOLUTION; CAPSULE; LIQUID
Drug_Category Antineoplastic Agents; ATC:L01CB01
Absorption Absorbed well, time to peak plasma concentration is 1-1.5 hrs
Interactions Interactions for Etoposide:

Caution should be exercised when administering ETOPOPHOS with drugs that are known to inhibit phosphatase activities (e.g., levamisole hydrochloride). High-dose cyclosporin A resulting in concentrations above 2000 ng/mL administered with oral etoposide has led to an 80% increase in etoposide exposure with a 38% decrease in total body clearance of etoposide compared to etoposide alone.

Toxicity Side effects include alopecia, constipation, diarrhea, nausea and vomiting and secondary malignancies (leukemia)
Organisms Affected Humans and other mammals
Chemical IUPAC Name 9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl
Chemical Formula C29H32O13
Molecular Weight 588.557 g/mol
Smiles String CC1OCC2C(O1)C(C(C(O2)OC3C4COC(=O)C4C(C5=CC6=C(C=C35)OCO6)C7=CC(=C(C(=C7)OC)O)OC)O)O
Melting Point 236-251 °C
Water Solubility 58.7 mg/L
State Solid
LogP/Hphobicity 1.285
Isoelectric Point Not Available
Biotransformation Primarily hepatic with 40% excreted unchanged in the urine
Half Life 4-11 hours
Protein Binding [%] 97%
RxList Link RXlist
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Drug Reference http://www.drugs.com/cons/Etoposide.html
http://www.rxlist.com/cgi/generic2/etopophos.htm
Drug Type Approved Drug
Accession No APRD00239
CAS Registry Number 33419-42-0
KEGG Compound ID C01576
PubChem ID SID:177966
PharmGKB ID PA449552
SwissProt ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] 2241182

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