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Ethoxzolamide
drug data and news
Ethoxzolamide drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Ethoxzolamide | ||
| Brand Names/Synonyms | Cardrase; Diuretic C; Ethamide; Ethoxazolamide; Ethoxyzolamide; Ethoxzolamide; Etoxzolamide; Glaucotensil; Redupresin; U-4191 | ||
| Indication | For use in the treatment of duodenal ulcers, as a diuretic, and in the treatment of glaucoma, and may also be useful in the treatment of seizures associated with epilepsy. | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Ethoxzolamide, a sulfonamide, inhibits carbonic anhydrase activity in proximal renal tubules to decrease reabsorption of water, sodium, potassium, bicarbonate. It also decreases carbonic anhydrase in the CNS, increasing the seizure threshold. This reduction in carbonic anhydrase also reduces the intraocular pressure in the eye by decreasing aqueous humor. | ||
| Mechanism Of Action | Ethoxzolamide binds and inhibits carbonic anhydrase I. Carbonic anhydrase plays an essential role in facilitating the transport of carbon dioxide and protons in the intracellular space, across biological membranes and in the layers of the extracellular space. The inhibition of this enzyme effects the balance of applicable membrane equilibrium systems. | ||
| Ethoxzolamide News (When available) |
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| Dosage Forms | TABLET (125, 250 mg), CAPSULE (500mg), INJECTION (500mg) | ||
| Drug_Category | Diuretics; Carbonic Anhydrase Inhibitors | ||
| Absorption | Rapidly absorbed with 65% bioavailability | ||
| Interactions |
Interactions for Ethoxzolamide: Ethoxzolamide may increase the action of tricyclics, amphetamines, procainamide, and quinidine. It may increase excretion of barbiturates, lithium, and ASA and may also increase the toxicity of salicylates. Coadministration of ethoxzolamide with other diuretics, amphotericin B, and corticosteroids may cause hypokalemia. | ||
| Toxicity | Not Available | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 6-ethoxybenzothiazole-2-sulfonamide | ||
| Chemical Formula | C9H10N2O3S2 | ||
| Molecular Weight | 258.319 g/mol | ||
| Smiles String | CCOC1=CC2=C(C=C1)N=C(S2)S(=O)(=O)N | ||
| Melting Point | 189 °C | ||
| Water Solubility | 40 mg/L | ||
| State | Solid | ||
| LogP/Hphobicity | 1.218 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Not Available | ||
| Half Life | 2.5-5.5 hours | ||
| Protein Binding [%] | ~89% | ||
| RxList Link | Not Available>RXlist | ||
| Sponsored links | |||
| Drug Reference | Not Available | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00732 | ||
| CAS Registry Number | 452-35-7 | ||
| KEGG Compound ID | Not Available | ||
| PubChem ID | SID:345073 | ||
| PharmGKB ID | Not Available | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | Not Available |
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