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Ethosuximide
drug data and news
Ethosuximide drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Ethosuximide | ||
| Brand Names/Synonyms | Aethosuximide; Asamid; Atysmal; C.I. 366; CI-366; Capitus; Cl 366; Emeside; Epileo Petit Mal; Ethosuccimide; Ethosuccinimide; Ethosuxide; Ethosuximide; Ethymal; Etomal; Etosuximid; Etosuximida; H 940; H-490; Mesentol; NSC-64013; PM 671; PM-671; Pemal; Pemalin; Pentinimid; Peptinimid; Petinimid; Petnidan; Piknolepsin; Pyknolepsinum; Ronton; Simatin; Succimal; Succimitin; Suxilep; Suximal; Suxin; Suxinutin; Thetamid; Thilopemal; Uritone; Urodeine; Zaraondan; Zarodan; Zarondan; Zarondan-Saft; Zarontin; Zartalin | ||
| Indication | For the treatment of petit mal epilepsy. | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Used in the treatment of epilepsy. Ethosuximide suppresses the paroxysmal three cycle per second spike and wave activity associated with lapses of consciousness which is common in absence (petit mal) seizures. The frequency of epileptiform attacks is reduced, apparently by depression of the motor cortex and elevation of the threshold of the central nervous system to convulsive stimuli. | ||
| Mechanism Of Action | Binds to T-type voltage sensitive calcium channels. Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by mibefradil. A particularity of this type of channels is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. | ||
| Ethosuximide News (When available) |
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| Dosage Forms | SYRUP | ||
| Drug_Category | Anticonvulsants; Succinimides; ATC:N03AD01 | ||
| Absorption | Not Available | ||
| Interactions |
Interactions for Ethosuximide: Since Zarontin (ethosuximide) may interact with concurrently administered antiepileptic drugs, periodic serum level determinations of these drugs may be necessary (eg, ethosuximide may elevate phenytoin serum levels and valproic acid has been reported to both increase and decrease ethosuximide levels). | ||
| Toxicity | Not Available | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 3-ethyl-3-methyl-pyrrolidine-2,5-dione | ||
| Chemical Formula | C7H11NO2 | ||
| Molecular Weight | 141.168 g/mol | ||
| Smiles String | CCC1(CC(=O)NC1=O)C | ||
| Melting Point | 64.5 °C | ||
| Water Solubility | 3.92E+004 mg/L | ||
| State | Solid | ||
| LogP/Hphobicity | 1.012 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Not Available | ||
| Half Life | Not Available | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Ethosuximide.html http://www.rxlist.com/cgi/generic2/ethosuximide.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00318 | ||
| CAS Registry Number | 77-67-8 | ||
| KEGG Compound ID | C07505 | ||
| PubChem ID | SID:312314 | ||
| PharmGKB ID | PA449533 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 23485 |
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