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Ethacrynic acid
drug data and news
Ethacrynic acid drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Ethacrynic acid | ||
| Brand Names/Synonyms | Crinuryl; Edecril; Edecrin; Edecrina; Endecril; Etacrinic Acid; Etacrynic Acid; Etakrinic Acid; Ethacrynate; Ethacrynic Acid; Hidromedin; Hydromedin; MK 595; MK-595; Methylenebutyrylphenoxyacetic Acid; Mingit; Otacril; Reomax; Taladren; Uregit | ||
| Indication | For treatment of edema when an agent with greater diuretic potential than those commonly employed is required used in pulmonary oedema in congestive cardiac failure; Renal and hepatic disease | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Ethacrynic acid, a monosulfonamyl diuretic, differs form other thiazide diuretics in that a double ring system is incorporated into its structure. Ethacrynic acid is used alone or with atenolol in the management of hypertension and edema. | ||
| Mechanism Of Action | Ethacrynic acid inhibits sodium ion transport across the renal tubular epithelium in the cortical diluting segment of the ascending limb of the loop of Henle. By increasing the delivery of sodium to the distal renal tubule, Ethacrynic acid indirectly increases potassium excretion via the sodium-potassium exchange mechanism. | ||
| Ethacrynic acid News (When available) |
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| Dosage Forms | TABLET | ||
| Drug_Category | Diuretics; Enzyme Inhibitors | ||
| Absorption | Not Available | ||
| Interactions |
Drug Interactions for Ethacrynic acid: Lithium generally should not be given with diuretics because they reduce its renal clearance and add a high risk of lithium toxicity. Read circulars for lithium preparations before use of such concomitant therapy. EDECRIN may increase the ototoxic potential of other drugs such as aminoglycoside and some cephalosporin antibiotics. Their concurrent use should be avoided. A number of drugs, including ethacrynic acid, have been shown to displace warfarin from plasma protein; a reduction in the usual anticoagulant dosage may be required in patients receiving both drugs. In some patients, the administration of a non- steroidal antiinflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium- sparing and thiazide diuretics. Therefore, when EDECRIN and non- steroidal anti- inflammatory agents are used concomitantly, the patient should be observed closely to determine if the desired effect of the diuretic is obtained. | ||
| Toxicity | Not Available | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 2-[2,3-dichloro-4-(2-ethylprop-2-enoyl)phenoxy]ethanoicacid | ||
| Chemical Formula | C13H12Cl2O4 | ||
| Molecular Weight | 303.137 g/mol | ||
| Smiles String | CCC(=C)C(=O)C1=C(C(=C(C=C1)OCC(=O)O)Cl)Cl | ||
| Melting Point | 122.5 °C | ||
| Water Solubility | Not Available | ||
| State | Solid | ||
| LogP/Hphobicity | 3.414 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Not Available | ||
| Half Life | Not Available | ||
| Protein Binding [%] | > 98% | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Ethacrynic_acid.html http://www.rxlist.com/cgi/generic3/edecrin.htm http://www.pharmgkb.org/views/index.jsp?objId= | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00251 | ||
| CAS Registry Number | 58-54-8 | ||
| KEGG Compound ID | C06983 | ||
| PubChem ID | SID:9197 | ||
| PharmGKB ID | PA449518 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2258528 |
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