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Etanercept
drug data and news
Etanercept drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Etanercept | ||
| Brand Names/Synonyms | Tumor necrosis factor receptor superfamily member 1B precursor;Tumor necrosis factor receptor 2;TNF-R2;Tumor necrosis factor receptor type II;p75;p80 TNF-alpha receptor;CD120b;Etanercept[Contains: Tumor necrosis factor binding protein 2;TBPII;TBP-2]; Enbrel (Immunex Corp) | ||
| Indication | For treatment of severe adult and juvenille rheumatoid arthritis | ||
| Sponsored links | Description | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1. The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of IgG1. Etanercept is produced by recombinant DNA technology in a Chinese hamster ovary (CHO) mammalian cell expression system. It consists of 934 amino acids | |
| Pharmacology | Used in the treatment of rheumatoid arthritis and the reduction of the adverse effects of tumor necrosis factor (TNF). TNF is a naturally occurring cytokine that is involved in normal inflammatory and immune responses. Elevated levels of TNF are found in tissues and fluids of patients with rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis (AS), and plaque psoriasis. Etanercept binds specifically to tumor necrosis factor (TNF) and blocks its interaction with cell surface TNF receptors. | ||
| Mechanism Of Action | There are two distinct receptors for TNF (TNFRs), a 55 kilodalton protein (p55) and a 75 kilodalton protein (p75). The biological activity of TNF is dependent upon binding to either cell surface receptor (p75 or p55). Etanercept is a dimeric soluble form of the p75 TNF receptor that can bind to two TNF molecules, thereby effectively removing them from circulation. | ||
| Etanercept News (When available) |
Bush incited pre-war fear Mar 2, 2006 Classic play reflects current political climate Feb 8, 2006 A modern lens for Sophocles' drama Feb 7, 2006 OSU Theatre performs Anouilh’s Antigone Feb 10, 2006 Modernization does 'Antigone' no real favors Updated language ... Feb 12, 2006 She’s Not Scared Feb 9, 2006 Teenage hubris Feb 12, 2006 She's not just treading water Teen with cystic fibrosis turned ... Mar 1, 2006 WASPS are bored at Theatre Memphis. Ann Tigony opens at ... Feb 17, 2006 Parts work, parts don't in 'Medea' Feb 24, 2006 Modern take infuses theater's 'Antigone' Feb 21, 2006 Dyleski friend continues testimony in Vitale case Feb 15, 2006 WESLEYAN PLAYERS PRESENT “ANTIGONE� Feb 14, 2006 BGSU welcomes magical 'Giants' Feb 16, 2006 LIMS Uptake on the Rise in Eastern Europe Feb 8, 2006 She’s Not Scared 09 Feb 2006 Classic play reflects current political climate Feb 8, 2006 A modern lens for Sophocles' drama Feb 7, 2006 LIMS Uptake on the Rise in Eastern Europe Feb 8, 2006 The Burial at Thebes Jan 26, 2006 Theater Department to Stage Seamus Heaney's New Version of ... Jan 6, 2006 'Thebes' shows Bay Area's talent pool's still brimming Jan 17, 2006 Dramatic Club seeks actors for unique Oedipus, Casablanca Jan 12, 2006 S&R Communications Group Named Agency of Record for CB Fleet® ... Jan 23, 2006 Theater Guide Dec 8, 2005 Stagings draw out Stravinsky's theatrical verve Dec 10, 2005 Don't blame the bird for feeling sleepy Dec 6, 2005 Daring yields magnificent reward Nov 30, 2005 Cystic fibrosis doesn't slow Centre student Nov 28, 2005 Secular groups offer up quite a musical feast this week Dec 9, 2005 'Antigone' rewritten transcends the ages Nov 17, 2005 The Burial At Thebes, Playhouse, Nottingham Nov 21, 2005 New in Paperback Dec 7, 2005 Fauquier High stages a classical Greek tragedy Nov 8, 2005 Horce racing action Nov 22, 2005 Wilsonville senior discovers his place to shine is onstage Nov 17, 2005 Christ the King is Blue Ribbon Nov 16, 2005 NFA world Parent conferences to be held in 3 sessions Nov 14, 2005 Drama class at GHS rehearses Medea Nov 11, 2005 Theater review: The relevance of 'Antigone' 31 Oct 2005 Sophocles, Harriet Miers and Creon Oct 23, 2005 SOLVAY PHARMACEUTICALS, INC. AWARDS 30 SCHOLARSHIPS TO STUDENTS ... Oct 25, 2005 For Whom They Toll Oct 26, 2005 Actors needed for supper theatre Oct 13, 2005 Sexy Rex can't kill the plot Oct 19, 2005 World-class bass to perform in Carlisle Oct 20, 2005 Troupe gives 'Medea' its own stamp New adaptation of ancient Greek ... Oct 11, 2005 Art Village Courtyard to present 'The Burial of Thebes' Oct 7, 2005 'Flags' gets its tragic point across even with new cast Oct 6, 2005 Troupe gives 'Medea' its own stamp New adaptation of ancient Greek ... 11 Oct 2005 Review: Only flashes of sublime appear in 'Antigone' Sep 27, 2005 A real Greek triumph Sep 12, 2005 Art Village Courtyard to present 'The Burial of Thebes' Oct 7, 2005 'Flags' gets its tragic point across even with new cast Oct 6, 2005 Sept. 30: Half-day, elementary Sep 20, 2005 | ||
| Dosage Forms | KIT;LIQUID;POWDER FOR SOLUTION | ||
| Drug_Category | Immunomodulatory Agents; Antirheumatic Agents; unclassified therapeutic agents (92:00.00) | ||
| Absorption | Not Available | ||
| Interactions | Not Available | ||
| Toxicity | Not Available | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | Human tumor necrosis factor receptor fusion protein | ||
| Chemical Formula | C2224H3475N621O698S36 | ||
| Molecular Weight | 51234.9 | ||
| Smiles String | Not Available | ||
| Melting Point | 71 oC (whole mAb) - Vermeer, A.W.P. & Norde, W., Biophys. J. 78:394-404 (2000). | ||
| Water Solubility | Not Available | ||
| State | Transparent, slightly viscous, aqueous liquid | ||
| LogP/Hphobicity | -0.529 | ||
| Isoelectric Point | 7.89 | ||
| Biotransformation | Not Available | ||
| Half Life | 102 +/- 30 hrs | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Etanercept.html http://www.rxlist.com/cgi/generic/etanercept.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | BIOD00052 | ||
| CAS Registry Number | 185243-69-0 | ||
| KEGG Compound ID | Not Available | ||
| PubChem ID | Not Available | ||
| PharmGKB ID | PA449515 | ||
| SwissProt ID | TNR1B_HUMAN (P20333) | ||
| GenBank ID | M32315 | ||
| Drug ID Number [DIN] | 2242903 |
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