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Estrone
drug data and news
Estrone drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Estrone | ||
| Brand Names/Synonyms | Aquacrine; CCRIS 285; Crinovaryl; Cristallovar; Crystogen; Destrone; Disynformon; Endofolliculina; Esterone; Estrin; Estrogenic Substance; Estrol; Estron; Estrona; Estrona [Inn-Spanish]; Estrona [Spanish]; Estrone; Estrone [Usan:Inn]; Estrone-A; Estronum [Inn-Latin]; Estrovarin; Estrugenone; Estrusol; Femestrone Inj.; Femestrone Injection; Femidyn; Fermidyn; Folikrin; Folipex; Folisan; Follestrine; Follestrol; Follicular Hormone; Folliculin; Folliculine; Folliculine Benzoate; Follicunodis; Follidrin; GSS 33; Glandubolin; HSDB 3324; Hiestrone; Hormestrin; Hormofollin; Hormovarine; Kestrone; Ketodestrin; Ketohydroxy-Estratriene; Ketohydroxyestrin; Ketohydroxyoestrin; Ketophydroxyestrin; Kolpon; Menagen; Menformon; Menformon A; Mestronaq; NSC 9699; OVEX; Oestrin; Oestroform; Oestrone; Oestrone [Steroidal Oestrogens]; Oestronum; Oestroperos; Ovifollin; Penncap M; Perlatan; Sinafid M-48; Solliculin; Theelin; Thelestrin; Thelykinin; Thynestron; Tokokin; Unden; Wynestron; Wynestronpencap M | ||
| Indication | For management of Menopausal and postmenopausal disorders | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Estrone, a synthetically prepared or naturally occurring steroidal estrogen obtained from pregnant equine urine, is the primary circulating estrogen after menopause. Estrone is naturally derived from the peripheral conversion of androstenedione by an aromatase enzyme found in adipose tissues and is converted to estradiol in peripheral tissues. Estropipate is piperazine-stabilized estrone sulfate. Estrone, and estropipate are used to treat abnormalities related to gonadotropin hormone dysfunction, vasomotor symptoms, atrophic vaginitis, and vulvar atrophy associated with menopause, and for the prevention of osteoporosis due to estrogen deficiency. | ||
| Mechanism Of Action | Estrogens enter the cells of responsive tissues (e.g., female organs, breasts, hypothalamus, pituitary) where they interact with a protein receptor, estrogen receptors, subsequently increasing the rate of synthesis of DNA, RNA, and some proteins. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary. | ||
| Estrone News (When available) |
Esterified Estrogen May Be Slightly Safer Than Conjugated Equine ... Mar 1, 2006 (PZ) Manhattan Pharmaceuticals' President and CEO Named Panelist ... Feb 10, 2006 Dietary Modification and Risk of Breast Cancer Feb 8, 2006 | ||
| Dosage Forms | Vaginal Cream; Vaginal Suppository; Patch; Skin Gel; Tablet; IM Injectable Suspension | ||
| Drug_Category | Antineoplastic Agents; Osteoporosis Prophylactic; Anti-menopausal Agents; Estrogens; ATC:G03CA07; ATC:G03CC04 | ||
| Absorption | 43% | ||
| Interactions | Drug Interactions -------------------------------------------------------------------------------- This medicine may be affected by the drug cholestyramine and should not be taken with any form of estrogen therapy. Talk to your pharmacist for more information. Drugs that may decrease the effects of this medicine include: Rifampin barbiturates phenytoin (Dilantin) carbamazepine (Tegretol) Estrogens may decrease the effects of benzodiazepines (lorezepam oxezepam temezepam). If you are taking these medicines together or you have further questions about drug interactions talk to your doctor or pharmacist. Consult your doctor or pharmacist if you are taking any of the following: seizure medications antibiotics warfarin medications to help you sleep | ||
| Toxicity | nausea and vomiting, and withdrawal bleeding may occur in females | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 3-hydroxy-13-methyl-6,7,8,9,11,12,13,14,15,16-decahydrocyclopenta[a]phenanthren-17-one | ||
| Chemical Formula | C18H22O2 | ||
| Molecular Weight | 270.366 g/mol | ||
| Smiles String | CC12CCC3C(C1CCC2=O)CCC4=C3C=CC(=C4)O | ||
| Melting Point | 254.5-256 °C | ||
| Water Solubility | 3 g/100mL | ||
| State | Solid | ||
| LogP/Hphobicity | 4.067 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | hepatic | ||
| Half Life | 19 hours | ||
| Protein Binding [%] | >95% | ||
| RxList Link | Not Available>RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Estrone.html http://www.pharmgkb.org/views/index.jsp?objId= | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00588 | ||
| CAS Registry Number | 53-16-7 | ||
| KEGG Compound ID | C00468 | ||
| PubChem ID | SID:148674 | ||
| PharmGKB ID | PA449512 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 727369 |
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