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Enprofylline
drug data and news
Enprofylline drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
Enprofylline
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| Brand Names/Synonyms |
A018; D-4028; ENPROFYLLINE; Enprofilina [Inn-Spanish]; Enprofylline [Usan:Inn]; Enprofyllinum [Inn-Latin]; Nilyph; Oxeze |
| Indication |
For management of symptoms of Asthma |
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Description |
Not Available |
| Pharmacology |
Enprofylline, a synthetic dimethylxanthine derivative structurally related to theophylline and caffeine, is used in the treatment of peripheral vascular diseases and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy. |
| Mechanism Of Action |
Enprofylline inhibits erythrocyte phosphodiesterase, resulting in an increase in erythrocyte cAMP activity. Subsequently, the erythrocyte membrane becomes more resistant to deformity. Along with erythrocyte activity, Enprofylline also decreases blood viscosity by reducing plasma fibrinogen concentrations and increasing fibrinolytic activity. Enprofylline also binds to the adenosine A(2B) receptor which prevents adenosine induced bronchoconstriction. |
Enprofylline News
(When available) |
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| Dosage Forms |
Not Available |
| Drug_Category |
Antiarrhythmic Agents; Anti-asthmatic Agents; Bronchodilator Agents; Anti-inflammatory Agents; |
| Absorption |
Not Available |
| Interactions |
Not Available |
| Toxicity |
Not Available |
| Organisms Affected |
Humans and other mammals |
| Chemical IUPAC Name |
3-propyl-3,7-dihydropurine-2,6-dione |
| Chemical Formula |
C8H10N4O2 |
| Molecular Weight |
194.191 g/mol |
| Smiles String |
CCCN1C2=C(C(=O)NC1=O)NC=N2 |
| Melting Point |
287-289 °C |
| Water Solubility |
1200 mg/L |
| State |
Solid |
| LogP/Hphobicity |
0.33 |
| Isoelectric Point |
Not Available |
| Biotransformation |
Not Available |
| Half Life |
Not Available |
| Protein Binding [%] |
50% |
| RxList Link |
Not Available>RXlist |
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| Drug Reference |
Not Available |
| Drug Type |
Approved Drug |
| Accession No |
APRD00273 |
| CAS Registry Number |
41078-02-8 |
| KEGG Compound ID |
Not Available |
| PubChem ID |
SID:179921 |
| PharmGKB ID |
Not Available |
| SwissProt ID |
Not Available |
| GenBank ID |
Not Available |
| Drug ID Number [DIN] |
Not Available
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