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Enflurane
drug data and news
Enflurane drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Enflurane | ||
| Brand Names/Synonyms | Alyrane; Anesthetic 347; Anesthetic Compound No. 347; C 347; Compound 347; Efrane; Enflurane; Enflurano [Inn-Spanish]; Enfluranum [Inn-Latin]; Ethrane; Methylflurether; Ohio 347 | ||
| Indication | For use as a Inhalation anaesthetic for general anesthesia and for analgesia for vaginal delivery. | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Enflurane is a general inhalation anesthetic used for induction and maintenance of general anesthesia. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability. It does so by decreasing the extent of gap junction mediated cell-cell coupling and altering the activity of the channels that underlie the action potential. Induction of and recovery from anesthesia with enflurane are rapid. Enflurane has a mild sweet odor. Enflurane may provide a mild stimulus to salivation or tracheobronchial secretions. Pharyngeal and laryngeal reflexes are readily obtunded. The level of anesthesia can be changed rapidly by changing the inspired enflurane concentration. | ||
| Mechanism Of Action | Enflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Enflurane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. Also appears to bind the D subunit of ATP synthase and NADH dehydogenase. Enflurane also binds to the GABA receptor, the large conductance Ca2+ activated potassium channel, the glutamate receptor and the glycine receptor. | ||
| Enflurane News (When available) |
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| Dosage Forms | LIQUID | ||
| Drug_Category | Anesthetics; General Anesthetics; ATC:N01AB04 | ||
| Absorption | Not Available | ||
| Interactions | Not Available | ||
| Toxicity | LD50=5.4 ml/kg (rat) | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 2-chloro-1-(difluoromethoxy)-1,1,2-trifluoro-ethane | ||
| Chemical Formula | C3H2ClF5O | ||
| Molecular Weight | 184.492 g/mol | ||
| Smiles String | C(C(OC(F)F)(F)F)(F)Cl | ||
| Melting Point | 56 oC (BP) | ||
| Water Solubility | insoluble | ||
| State | Liquid | ||
| LogP/Hphobicity | 2.597 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Leads to low levels of serum fluoride (15 micomol/L). | ||
| Half Life | Not Available | ||
| Protein Binding [%] | 97% | ||
| RxList Link | Not Available>RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Enflurane.html http://www.minrad.com/clin/s347.html | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00234 | ||
| CAS Registry Number | 13838-16-9 | ||
| KEGG Compound ID | C07516 | ||
| PubChem ID | SID:169039 | ||
| PharmGKB ID | PA449461 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 778370 |
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