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Dyphylline
drug data and news
Dyphylline drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Dyphylline | ||
| Brand Names/Synonyms | Afi-Phyllin; Aristophyllin; Asthmolysin; Astrophyllin; Circain; Cor-Theophylline; Coronal; Coronarin; Corphyllin; DT; Dihydroxypropyl Theophylline; Dihydroxypropyl Theopylin; Dilor; Dilor-400; Diphyllin; Diprofillin; Diprofilline; Diprophyllin; Diprophylline; Dipropylline; Droxine; Dyflex; Dyphylline; Glyfyllin; Glyphyllin; Glyphylline; Hidroxiteofillina; Hiphyllin; Hyphylline; Iphyllin; Liactemin; Lufyllin; Lufyllin-400; Neo-Vasophylline; Neophyl; Neophyllin; Neophylline; Neostenovasan; Neothylline; Neotilina; Neufil; Neutrafil; Neutrafillina; Neutraphyllin; Neutraphylline; Neutroxantina; Propyphyllin; Protheophylline; Purifilin; Silbephyllin; Silbephylline; Solufilin; Solufyllin; Soluphyllin; Synthophylline; Tefilan; Teofen; Theal; Thefylan | ||
| Indication | For relief of acute bronchial asthma and for reversible bronchospasm associated with chronic bronchitis and emphysema. | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Dyphylline, a xanthine derivative, is a bronchodilator used for relief of acute bronchial asthma and for reversible bronchospasm associated with chronic bronchitis and emphysema. Dyphylline is a xanthine derivative with pharmacologic actions similar to theophylline and other members of this class of drugs. Its primary action is that of bronchodilation, but it also exhibits peripheral vasodilatory and other smooth muscle relaxant activity to a lesser degree. | ||
| Mechanism Of Action | The bronchodilatory action of dyphylline, as with other xanthines, is thought to be mediated through competitive inhibition of phosphodiesterase with a resulting increase in cyclic AMP producing relaxation of bronchial smooth muscle. | ||
| Dyphylline News (When available) |
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| Dosage Forms | ELIXIR; LIQUID; SOLUTION; SUPPOSITORY; TABLET | ||
| Drug_Category | Vasodilator Agents; Bronchodilator Agents; Respiratory Smooth Muscle Relaxants; Phosphodiesterase Inhibitors; ATC:R03DA01 | ||
| Absorption | Not Available | ||
| Interactions |
Interactions for Dyphylline: Synergism between xanthine bronchodilators (e.g., theophylline), ephedrine, and other sympathomimetic bronchodilators has been reported. This should be considered whenever these agents are prescribed concomitantly. Concurrent administration of dyphylline and probenecid, which competes for tubular secretion, has been shown to increase the plasma half-life of dyphylline . | ||
| Toxicity | Oral, mouse LD50: 1954 mg/kg | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 7-(2,3-dihydroxypropyl)-1,3-dimethyl-3,7-dihydropurine-2,6-dione | ||
| Chemical Formula | C10H14N4O4 | ||
| Molecular Weight | 254.243 g/mol | ||
| Smiles String | CN1C2=C(C(=O)N(C1=O)C)N(C=N2)CC(CO)O | ||
| Melting Point | 161.5 °C | ||
| Water Solubility | 0.33 g/ml | ||
| State | Solid (white, crystalline powder) | ||
| LogP/Hphobicity | -1.46 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Hepatic. | ||
| Half Life | 2 hours (range 1.8 - 2.1 hours) | ||
| Protein Binding [%] | 84% | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Dyphylline.html http://www.rxlist.com/cgi/generic2/dyphylline.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00769 | ||
| CAS Registry Number | 479-18-5 | ||
| KEGG Compound ID | C07819 | ||
| PubChem ID | SID:10021 | ||
| PharmGKB ID | PA449426 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 26751 |
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