Doxycycline drug data and news

Doxycycline drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name Doxycycline
Brand Names/Synonyms Alti-Doxycycline; Apo-Doxy; Atridox; DOXCYCLINE ANHYDROUS; Doryx; Doxy 100; Doxy-Caps; Doxy-Lemmon; Doxychel; Doxychel Hyclate; Doxycin; Doxycycline; Doxycycline Hyclate; Doxycycline Monohydrate; Doxylin; Doxytec; Doxytetracycline; GS-3065; Jenacyclin; Monodox; Novo-Doxylin; Nu-Doxycycline; Periostat; Supracyclin; Vibra-Tabs; Vibramycin
Indication For the treatment of the following infections:Rocky mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsialpox, and tick fevers caused by Rickettsiae, Chancroid caused by Haemophilus ducreyi, Uncomplicated gonorrhea caused by Neisseria gonorrhoeae, Respiratory tract infections caused by Mycoplasma pneumoniae or Streptococcus pneumoniae. Lymphogranuloma ve
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Description Not Available
Pharmacology Doxycycline, a long-acting tetracycline derived from oxytetracycline, is used to inhibit bacterial protein synthesis and treat non-gonococcal urethritis and cervicitis, exacerbations of bronchitis in patients with COPD, and adult periodontitis.
Mechanism Of Action Doxycycline, like minocycline, is lipophilic and can pass through the lipid bilayer of bacteria. Doxycycline reversibly binds to the 30 S ribosomal subunits and possibly the 50S ribosomal subunit(s), blocking the binding of aminoacyl tRNA to the mRNA and inhibiting bacterial protein synthesis.
Doxycycline News
(When available)

Individualized treatment options for rosacea  06 Mar 2006
Oral tetracycline antibiotics, such as doxycycline or minocycline, are the most common oral medications used to treat rosacea. A ... - News-Medical.net,

The Trouble With Ticks: A Common Source of Illness  Feb 9, 2006
Treatment with doxycycline in patients older than 8 years or amoxicillin in those younger than 8 at the early localized stage is universally effective. ... - Medscape (subscription)

Par Pharmaceutical Reports Sales and Earnings for 2005  Feb 28, 2006
...final FDA approval following which Par began shipping ribavirin 200 mg, 400 mg, and 600 mg tablets; - Par began shipping doxycycline monohydrate tablets, an ... - MSN Money

Autophagy-mediated clearance of huntingtin aggregates triggered by ...  Feb 27, 2006
Abbreviations used in this paper: ALS, amyotrophic lateral sclerosis; ANOVA, analysis of variance; dox, doxycycline; HD, Huntington's disease; htt, huntingtin ... - Journal of Cell Biology

CollaGenex Pharmaceuticals Reports Financial Results for the ...  Feb 28, 2006
...expenses. Periostat's share of total prescriptions filled for 20 mg doxycycline during the fourth quarter averaged approximately 15.5%. ... - Business Wire (press release),

Highlights From MMWR: HIV/AIDS Rates Highest in Blacks and More  Feb 10, 2006
...to overflow its banks. The infection resolved after empiric treatment with oral doxycycline. Although subsequent investigation identified ... - Medscape (subscription)

Discovering What Works on Anthrax  Feb 20, 2006
Instead, two other antibiotics, ciprofloxacin and doxycycline are recommended by the Centers for Disease Control and Prevention. ... - New York Times,

Facts about anthrax  Feb 22, 2006
A. The Food and Drug Administration has approved ciprofloxacin, doxycycline and penicillin for the treatment of anthrax in adults and children. - Newsday,

New Yorker infected with inhaled anthrax  Feb 23, 2006
Health-care providers will use antibiotics (such as ciprofloxacin, levofloxacin, doxycycline, or penicillin) combined with the anthrax vaccine to prevent ... - Food Consumer,

The Medical State Of The Men Infected With Antrax Is Deteriorating  Feb 26, 2006
Treatment for anthrax infection includes large doses of intravenous and oral antibiotics, such as penicillin, ciprofloxacin, doxycycline, erythromycin, and ... - Playfuls.com,

Engineered Mouse Mimics Cognitive Aspects Of Schizophrenia  Feb 24, 2006
What's more, they engineered the mouse strain so that they could shut down this overexpression by giving the mice the antibiotic doxycycline. ... - Science Daily (press release)

US CDC confirms four 'Lepto' deaths  Feb 16, 2006
...times. The prophylactic doxycycline tablet is a way of preventing the disease but not many people have taken it this year, he added. ... - Stabroek News,

Marin keeps focus on Lyme disease  Feb 21, 2006
Lyme disease. She took a low dose of the antibiotic Doxycycline for two weeks, and she assumed that would be the end of it. "I didn ... - Marin Independent-Journal,

INDIA: LAST OF A SERIES  Feb 11, 2006
Total cost was about $200. Medicine to carry: The doctor at the Travelers' HealthCare Center prescribed an antibiotic, doxycycline, for malaria prevention. ... - Cleveland Plain Dealer,

Guyana: Floods Information Bulletin No. 3  Feb 9, 2006
...had been in non-flood areas. Stocks of the antibiotic, ‘Doxycycline’, are available in Guyana. An estimated 95 percent (or around ... - ReliefWeb (press release),

Rare chlamydia strain raising concern  Feb 6, 2006
Three weeks of the antibiotic doxycycline effectively treats LGV. But patients have to know they’re at risk, and then find a test. ... - MSNBC

Rare Chlamydia Strain Infecting Gay Men  Feb 6, 2006
Three weeks of the antibiotic doxycycline effectively treats LGV. But patients have to know they‘re at risk, and then find a test. ... - Jackson News-Tribune,

More virulent strain of chlamydia rising among gay men  Feb 7, 2006
...that.". Three weeks of the antibiotic doxycycline effectively treats LGV. But patients have to know they are at risk, and get tested. ... - Philadelphia Inquirer,

Plethico Pharmaceuticals files Draft Red Herring Prospectus with ...  Feb 14, 2006
...always believing in innovation. We pioneered introduction of Doxycycline based unique anti-biotic formulation. We also introduced ... - Moneycontrol.com,

ANIMAL DOCTOR  Feb 7, 2006
A short course of prednisone treatment is in order. British veterinarians have reported some success also using doxycycline. Avoid ... - Washington Post,

Guyanese in California raise US$1,600 for flood relief  Feb 15, 2006
Among the medicines were the much-needed doxycycline tablets, a common treatment for the deadly leptospirosis, a flood-related disease. - Stabroek News,

Acne and pimples: what can I do?  Feb 17, 2006
...preoccupation and frustration. Oral antibiotics, such as tetracycline and doxycycline, are often prescribed for acne. But the researchers ... - Fortnightly Tenerife News,

Roving chlamydia: LGV upsurge  Feb 14, 2006
...genitalia. However, some people may not exhibit any symptoms. LGV is treatable with a three-week course of doxycycline. Although ... - The University of Hawaii Kaleo,

Leader Speak  Feb 1, 2006
We have many firsts to our credit. We were the first to launch Doxycycline (Minicycline) and Cotrimoxazole (Timizole) in the Indian market. ... - India Infoline.com,

Guyana: Floods OCHA Situation Report No. 1  Feb 1, 2006
...leptospirosis. Prophylactic doxycycline is being administered in the flooded areas and in other areas where cases have been detected. ... - ReliefWeb (press release),

The Trouble With Ticks: A Common Source of Illness  09 Feb 2006
Treatment with doxycycline in patients older than 8 years or amoxicillin in those younger than 8 at the early localized stage is universally effective. ... - Medscape (subscription)

Guyana: Floods Information Bulletin No. 3  09 Feb 2006
...had been in non-flood areas. Stocks of the antibiotic, ‘Doxycycline’, are available in Guyana. An estimated 95 percent (or around ... - ReliefWeb (press release),

Health Ministry greenlights over-the-counter doxycycline  Jan 21, 2006
In the light of the current flood situation, the Ministry of Health has given private pharmacies clearance to sell doxycycline tablets without a prescription ... - Stabroek News,

Rare Chlamydia Strain Infecting Gay Men  Feb 8, 2006
Three weeks of the antibiotic doxycycline effectively treats LGV. But patients have to know they‘re at risk, and then find a test. ... - The Kindred Times,

National News Briefs  Feb 8, 2006
Three weeks of the antibiotic doxycycline effectively treats LGV. But patients have to know they're at risk, and then find a test. TOPEKA, Kan. ... - pride source.com,

ANIMAL DOCTOR  Feb 7, 2006
A short course of prednisone treatment is in order. British veterinarians have reported some success also using doxycycline. Avoid ... - Washington Post,

Rx problems: Malaria meds left in bottles  Jan 25, 2006
...visiting. Connolly said there are four medicines NU prescribes to prevent malaria: Malarone, Doxycycline, Lariam and Chloroquine. ... - Daily Northwestern,

BITTER PILL$ FOR NYERS  Jan 13, 2006
Price differences ranged from 13 percent more for Lanoxin, used to treat congestive heart failure, to 384 percent more for Doxycycline, which treats bacterial ... - New York Post,

Dengue fever is on the rise as world health risks change  Jan 22, 2006
Doxycycline [an antibiotic] cures it quickly. Most doctors prescribe a one-week course to be certain. But in reality a single dose of doxycycline" can cure it. ... - Los Angeles Times,

Leader Speak  Feb 1, 2006
We have many firsts to our credit. We were the first to launch Doxycycline (Minicycline) and Cotrimoxazole (Timizole) in the Indian market. ... - India Infoline.com,

Ramsammy urges flood-affected residents to take all precautions  Jan 27, 2006
There has been a very low intake of doxycycline tablets this flood season and Minister of Health, Dr. Leslie Ramsammy is concerned about whether residents in ... - Stabroek News,

Bird people risk parrot fever  Jan 27, 2006
Karen and Stefanie's GP therefore didn't wait to put them on a 10-day course of doxycycline, the antibiotic of choice for treating this infection. ... - Health24.com,

Guyana: Floods OCHA Situation Report No. 1  Feb 1, 2006
...leptospirosis. Prophylactic doxycycline is being administered in the flooded areas and in other areas where cases have been detected. ... - ReliefWeb (press release),

'Lepto' threat lurks again  Jan 6, 2006
In addition to that, he said the prophylactic treatment of two 100mg doxycycline tablets that were distributed last January, is being offered once more and ... - Stabroek News,

Uninsured NY'ers pay more than double for meds  Jan 12, 2006
Price differences ranged from 13 percent more for Lanoxin, which is used to treat congestive heart failure, to 384 percent more for Doxycycline, which treats ... - New York Daily News,

Report: Uninsured pay far too much for their prescriptions  Jan 13, 2006
The differences ranged from 13 percent more for Lanoxin, a heart drug, to 384 percent more for Doxycycline, which fights infections. ... - Poughkeepsie Journal,

Empty hospital beds in Rwanda show cholera epidemic is fading  Jan 11, 2006
...salts and constant fluids. The more serious cases require the antibiotic doxycycline along with intravenous fluids. Since cholera is ... - Catholic News Service

Volunteers would drive any epidemic battle, Altepeter says  Jan 10, 2006
For example, an outbreak of smallpox would require mass injections of vaccine, while anthrax would call for dispensing Doxycycline and Cipro, two kinds of ... - Crookston Daily Times,

Lyme Disease In Dogs, A Serious Matter For Everyone  Jan 12, 2006
Treatment involves the use of an antibiotic, such as doxycycline, for three to four weeks. There is a vaccine for the prevention of Lyme disease. ... - Open PR (press release),

Health Beat  Jan 19, 2006
...antibiotics. But LGV is much tougher to treat. The regimen is doxycycline taken twice a day for five to six weeks. The information ... - Bay Area Reporter,

Health team at Shafeek's residence in Charity  Jan 20, 2006
...from 9 am each day. The team will also distribute doxycycline tablets for the prevention of leptospirosis. Residents are asked to ... - Stabroek News,

High rate of resistance means azithromycin shouldn't be used to ...  Jan 11, 2006
...for syphilis in the US is intramuscular injection with benzathine penicillin G. For individuals who are allergic to penicillin, oral doxycycline is an accepted ... - Aidsmap,

Guyana's Health Minister warns of leptospirosis ahead of rainy ...  Jan 8, 2006
...disease. The Ministry of Health has advised that citizens take prophylactic doses of doxycycline, two pills (200mg) every five days. ... - Caribbean Net News,

Slurping birth defects  Jan 20, 2006
The prescription drugs temazepam, alprazolam and lorazepam (prescribed for anxiety and insomnia) as well as doxycycline (an antibiotic) also pose risks to ... - The California Aggie Online

Woman’s plight reveals trouble with antibiotics  Jan 9, 2006
...antibiotic, which she took for three years. The capsules, Doxycycline hyclate, kept her complexion clear. But she and her doctor think ... - Columbus Dispatch,

What is leptospirosis?  Jan 6, 2006
Leptospirosis is treated with antibiotics, such as doxycycline or penicillin, which should be given early in the course of the disease. ... - Stabroek News,

Malaria, UK Agency Warns Winter Sun Seekers  11 Dec 2005
The current recommended preventive treatments for travellers to The Gambia are atovaquone/proguanil (Malarone), doxycycline or mefloquine (Lariam). ... - Medical News Today (press release),

Culprit in Alzheimer's Disease May Have a Good Side  Dec 7, 2005
They used mice that were genetically engineered so that adding the antibiotic doxycycline to their food would suppress production of p25. ... - Howard Hughes Medical Institute,

A shot in the dark?  Nov 21, 2005
The groups treated with the antibiotics Ciprofloxacin or Doxycycline showed death rates of 11 percent and 10 percent, respectively. ... - Health Sentinel

Early Anti-amyloid Treatments in Alzheimer's are most effective  Nov 15, 2005
...produced. Commonly known as the tet-off system, the switch is turned off when the mice are fed tetracycline or its analog, doxycycline. ... - RxPG NEWS,

New Beauty: Coping with life in rosacea's red zone  Nov 28, 2005
...dermatologists. First, Periostat, an antibiotic originally developed to treat gum disease, is doxycycline taken twice daily for rosacea. ... - Naples Daily News (subscription),

Man found with 27 types of drugs  Nov 29, 2005
Some of the medicines he was found with are Clotrimazole, Aminophylline tablets, Penicillin, Doxycycline, Methyldopa, Streptomycin (for TB treatment) and X-ray ... - The Nation, Malawi,

PM faces revolt over abortion pill  Nov 16, 2005
...published in the journal Human Reproduction, found mifepristone (another name for RU486), combined with either ethinyl estradiol or doxycycline, reduced the ... - The Age (subscription),

Preventing malaria  Nov 18, 2005
...resistant malaria exists. The antibiotic doxycycline can also be used in areas of chloroquine resistance. Chloroquine is generally ... - Health24.com,

Dermatologists discuss myths surrounding -- and treatments for ...  Nov 10, 2005
...topical ointments have failed to clear the complexion, a dermatologist may prescribe an oral antibiotic, such as tetracycline, doxycycline, minocycline or ... - Victorville Daily Press,

STDs most common, prevalent college student threat  Nov 11, 2005
...is transmitted through vaginal, anal and oral sex, but because it is a bacteria-derived STD, it can eventually be cured using antibiotics, such as doxycycline. ... - The Triangle

RNAi the natural way  Nov 24, 2005
Trp53-specific siRNA, and hence of p53 protein, could be tightly and stably regulated both in culture and in mice by changing the level of doxycycline in the ... - Nature.com (subscription),

Doxycycline Could Enhance Interferon Beta 1-a (Avonex) Therapy in ...  Oct 4, 2005
THESSALONIKI, GREECE -- October 4, 2005 -- Interim findings from an ongoing study suggest that the addition of oral doxycycline to interferon beta 1-a (Avonex ... - DG News

Reports of 'doggie flu' spreading  Oct 10, 2005
Oft-prescribed Baytril is inappropriate for such secondary infections, he says, while other antibiotics, such as doxycycline, are far more effective. ... - Newsday,

Fundraiser to help painting duo keep up the good fight  Oct 5, 2005
They prescribed the antibiotic Doxycycline and sent him home. By Sunday, he was having a hard time breathing and his legs were severely swollen. ... - Chetek Alert,

Sleuthing a Rash  Oct 8, 2005
...is Rocky Mountain spotted fever, and I would have completely missed it if I hadn't listened to you." He started the patient on Doxycycline - the antibiotic of ... - New York Times,

Go To Girl wrote:  Sep 15, 2005
Prescription-wise, he did Doxycycline, Benzaclin, and Retin-A after that and that helped a bit, but it seemed like he would develop a tolerance to it and he'd ... - PanthersHuddle.com,

Evidence Of A New Hereditary Joint Disorder  Sep 30, 2005
Osteoarthritis (June 29, 2005) -- Featured in the July 2005 issue of Arthritis & Rheumatism, the findings of a new study suggest that doxycycline may slow the ... - Science Daily (press release)

HGSI Strikes Anthrax Deal  Oct 3, 2005
There were 22 cases recorded in total. Current US FDA-approved treatments for anthrax include antibiotics, ciprofloxacin, doxycycline, and penicillin. - Red Herring,

FDA will consider CollaGenex skin drug  Oct 3, 2005
Periostat has the same active ingredient, the antibiotic doxycycline, as Oracea. About 13.6 million adults in the United States suffer from rosacea. ... - Philadelphia Business Journal,

JHU Expert Warns of Spread of Rocky Mountain Spotted Fever  Oct 3, 2005
Initial treatment for adults, he said, involves immediate, twice daily 100-milligram doses of the oral antibiotic doxycycline (a version of the common ... - Johns Hopkins Gazette,

Australian troops claim drug side effects  Sep 29, 2005
DoD healthcare providers follow a policy of using FDA-approved drugs and CDC recommendations for the use of mefloquine (Lariam), doxycycline and Malarone. ... ... - United Press International

Katrina taught us: In case of attack, don't look to Uncle Sam  Oct 1, 2005
Contact numbers for the family, emergency routes and a full tank of gas. • First-aid kit with medicine and the antibiotics Cipro and doxycycline. ... - Milwaukee Journal Sentinel,

Taking Antibiotics for Acne May Increase Risk of Upper Respiratory ...  Sep 20, 2005
...colleagues. "Topical erythromycin and clindamycin and oral minocycline, doxycycline, and tetracycline are frequently used to treat acne. ... - Medscape (subscription)

Infected ticks found in Arizona  Sep 11, 2005
...plummeted. Rocky Mountain spotted fever can be arrested early with specific antibiotics, particularly one called doxycycline. But ... - Arizona Daily Sun,

Azithromycin versus Penicillin G Benzathine for Early Syphilis  Sep 24, 2005
For those with penicillin allergy, the forthcoming US guidelines list 100 mg of doxycycline given orally twice daily for 14 days, 1 g of ceftriaxone daily ... - New England Journal of Medicine (subscription),

BR hospitals denied stock of medicine for disaster  Sep 20, 2005
...anthrax. Included are Cipro and doxycycline, both antibiotics, and a variety of biochemical antidotes for nerve-gas agents. Minsky ... - 2theadvocate.com,

URL/Mutual Tracking to Achieve Another Record Year in Sales ...  Sep 12, 2005
Other recent URL/Mutual launches include Clonidine 0.1mg, 0.2mg, and 0.3mg Tablets (AB-rated to Catapres), Doxycycline Hyclate 20mg Tablets (AB-rated to ... - PR Newswire (press release),

Treating a Global Health Problem in Children  Sep 14, 2005
Researchers point out a single-dose treatment, either with ciprofloxacin or doxycycline, is the standard treatment for cholera in adults. ... - Ivanhoe

Aqua Pharmaceuticals Licenses Cordran(R) and Monodox(R) for the ...  Sep 22, 2005
...to market Cordran(R) (flurandrenolide USP), a family of topical steroids, and the antibiotic Monodox(R) (doxycycline monohydrate) 50mg and 100mg capsules. ... - PR Newswire (press release),

Sunil Jain:Killer cure  Sep 13, 2005
During the Mumbai floods, when the authorities desperately needed doxycycline to control water-borne diseases, this DPCO drug was simply not available. ... - Business Standard,

Dog tick shows new potential for disease spread  Sep 18, 2005
The only way to get a definitive diagnosis is through a lab test. Antibiotics, particularly doxycycline, are effective when given early. ... - Quincy Herald Whig,

Many meds don't mix with the sun  Sep 21, 2005
...cefazolin (Ancef), ceftazidime (Fortaz), ciprofloxacin (Cipro), cycloserine (Seromycin), dapsone, de-meclocycline (Declomycin), doxycycline (Vibramycin) ethio ... - Pioneer Press,

Vibrio Illnesses After Hurricane Katrina - Multiple States, August ...  Sep 17, 2005
V. vulnificus was isolated from her blood. As of September 12, she was being treated with ceftazidime and doxycycline and remained in critical condition. ... - Food Consumer,

IDPL units to be revived  Sep 9, 2005
In this regard, Paswan appreciated the contribution of IDPL to supplying Doxycycline to the victims of the recent floods in Mumbai at a very short notice. ... - Chennai Online,

Dosage Forms Tablet; Capsule; Gel; Liquid; Powder; Powder for Solution
Drug_Category Antimalarials; Anti-bacterial Agents; Tetracyclines; ATC:A01AB22; ATC:J01AA02
Absorption completely absorbed after oral administration
Interactions -->Interactions for Doxycycline:

Because tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage.

Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tetracyclines in conjunction with penicillin.

Absorption of tetracyclines is impaired by antacids containing aluminum, calcium, or magnesium, and iron-containing preparations.

Absorption of tetracycline is impaired by bismuth subsalicylate.

Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline.

The concurrent use of tetracycline and Penthrane (methoxyflurane) has been reported to result in fatal renal toxicity.

Concurrent use of tetracycline may render oral contraceptives less effective.

Drug/Laboratory Test Interactions

False elevations of urinary catecholamine levels may occur due to interference with the fluorescence test.

Toxicity anorexia, nausea, diarrhoea, glossitis, dysphagia, enterocolitis and inflammatory lesions (with monilial overgrowth) in the anogenital region. skin reactions such as maculopapular and erythematous rashes, exfoliative dermatitis, photosensitivity, hypersensitivity reactions such as urticaria, angioneurotic oedema, anaphylaxis, anaphyl-actoid purpura, pericarditis, and exacerbation of systemic lupus erythematosus, benign intracranial hypertension in adults disappearing on discontinuation of the medicine, haematologic abnormalities such as haemolytic anaemia, thrombocytopenia, neutropenia, and eosinophilia. LD50=262 mg/kg(i.p. in rat)
Organisms Affected Enteric bacteria and other eubacteria
Chemical IUPAC Name 2-(amino-hydroxy-methylidene)-4-dimethylamino-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione
Chemical Formula C22H24N2O8
Molecular Weight 444.435 g/mol
Smiles String CC1C2C(C3C(C(=O)C(=C(N)O)C(=O)C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)N(C)C)O
Melting Point 201 °C
Water Solubility 630 mg/L
State light-yellow crystalline powder
LogP/Hphobicity -1.219
Isoelectric Point Not Available
Biotransformation hepatic
Half Life 18-22 hours
Protein Binding [%] >90%
RxList Link RXlist
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Drug Reference http://www.drugs.com/cons/Doxycycline.html
http://www.rxlist.com/cgi/generic/doxycyc.htm
Drug Type Approved Drug
Accession No APRD00597
CAS Registry Number 564-25-0
KEGG Compound ID C06973
PubChem ID SID:154560
PharmGKB ID PA449415
SwissProt ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] 742562

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