| Generic name |
Dornase alfa (Dnase)
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| Brand Names/Synonyms |
Deoxyribonuclease-1 precursor;Deoxyribonuclease I;DNase I;Dornase alfa; Pulmozyme (Genentech Inc); Dilor; Dilor-400; Lufyllin; Lufyllin-400; Neothylline |
| Indication |
For treatment of cystic fibrosis |
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Description |
Recombinant human deoxyribonuclease I. Delivered by aerosol mist. The protein is produced by genetically engineered Chinese Hamster Ovary (CHO) cells containing DNA encoding for the native human protein, deoxyribonuclease I (DNase). 260 residues |
| Pharmacology |
cystic fibrosis (CF) is a disease characterized by the retention of viscous purulent secretions in the airways. These thick secretions contribute both to reduced pulmonary function and to frequent pulmonary infection. Purulent pulmonary secretions contain very high concentrations of extracellular DNA released by degenerating leukocytes that accumulate in response to these infections. Pulmozyme hydrolyzes the DNA in sputum of CF patients and reduces sputum viscoelasticity. |
| Mechanism Of Action |
Pulmozyme hydrolyzes DNA, thereby degrading large, viscous DNA molecules into small, soluble fragments that are easily cleared from the lungs. |
Dornase alfa (Dnase) News
(When available) |
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| Dosage Forms |
SOLUTION |
| Drug_Category |
Enzyme replacement; enzymes (44:00.00) |
| Absorption |
Not Available |
| Interactions |
Not Available |
| Toxicity |
Not Available |
| Organisms Affected |
Humans and other mammals |
| Chemical IUPAC Name |
Human deoxyribonuclease I |
| Chemical Formula |
C1321H1999N339O396S9 |
| Molecular Weight |
29253.9 |
| Smiles String |
Not Available |
| Melting Point |
67 oC (Chan, H.K. et al., Pharm Res. 13:756-761 (1996)) |
| Water Solubility |
Not Available |
| State |
Transparent, slightly viscous, aqueous liquid |
| LogP/Hphobicity |
-0.083 |
| Isoelectric Point |
4.58 |
| Biotransformation |
Not Available |
| Half Life |
Not Available |
| Protein Binding [%] |
Not Available |
| RxList Link |
RXlist |
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| Drug Reference |
http://www.rxlist.com/cgi/generic3/pulmozyme.htm |
| Drug Type |
Approved Drug |
| Accession No |
BIOD00001 |
| CAS Registry Number |
9003-98-9 |
| KEGG Compound ID |
Not Available |
| PubChem ID |
Not Available |
| PharmGKB ID |
PA10318 |
| SwissProt ID |
DNAS1_HUMAN (P24855) |
| GenBank ID |
M55983 |
| Drug ID Number [DIN] |
2046733
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