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Domperidone
drug data and news
Domperidone drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Domperidone | ||
| Brand Names/Synonyms | CHEMBANK2830; D122; Domperidona [Inn-Spanish]; Domperidone; Domperidone [Usan:Ban:Inn:Jan]; Domperidonum [Inn-Latin]; Duloxetine; Duloxetine Hcl; Duloxetine Hydrochloride; KW 5338; KW-5338; Motilium | ||
| Indication | For management of Dyspepsia, Heartburn, Epigastric pain, Nausea, Vomiting | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Domperidone is indicated for treating symptoms associated with upper gastrointestinal motility disorders caused by chronic and subacute gastritis. It is a gastrointestinal emptying (delayed) adjunct, a peristaltic stimulant, and also exhibits antiemetic properties. | ||
| Mechanism Of Action | Gastrointestinal emptying (delayed) adjunct; peristaltic stimulant: The gastroprokinetic properties of domperidone are related to its peripheral dopamine receptor blocking properties. Domperidone facilitates gastric emptying and decreases small bowel transit time by increasing esophageal and gastric peristalsis and by lowering esophageal sphincter pressure. Antiemetic: The antiemetic properties of domperidone are related to its dopamine receptor blocking activity at both the chemoreceptor trigger zone and at the gastric level. | ||
| Domperidone News (When available) |
Thoroughbred Times, Progesterone is found in Regu-Mate; sulpiride, which is used to treat psychosis in humans, is similar to domperidone, a drug widely used in the horse industry ... | ||
| Dosage Forms | TABLET | ||
| Drug_Category | Antiemetics; Miscellaneous GI drugs; ATC:A03FA03; Dopamine Antagonists | ||
| Absorption | Fast | ||
| Interactions | Not Available | ||
| Toxicity | Side effects include galactorrhea, gynecomastia, or menstrual irregularities. | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 5-chloro-1-[1-[3-(2-oxo-1,3-dihydrobenzoimidazol-1-yl)propyl]-4-piperidyl]-1,3-dihydrobenzoimidazol-2-one | ||
| Chemical Formula | C22H24ClN5O2 | ||
| Molecular Weight | 425.911 g/mol | ||
| Smiles String | C1CN(CCC1N2C3=C(C=C(C=C3)Cl)NC2=O)CCCN4C5=CC=CC=C5NC4=O | ||
| Melting Point | 242.5 °C | ||
| Water Solubility | 0.986 mg/L | ||
| State | Solid | ||
| LogP/Hphobicity | 2.527 | ||
| Isoelectric Point | 7.9 | ||
| Biotransformation | Not Available | ||
| Half Life | 7 hours | ||
| Protein Binding [%] | 91%-93% | ||
| RxList Link | Not Available>RXlist | ||
| Sponsored links | |||
| Drug Reference | http://www.drugs.com/cons/Domperidone.html | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00418 | ||
| CAS Registry Number | 57808-66-9 | ||
| KEGG Compound ID | C13212 | ||
| PubChem ID | SID:183089 | ||
| PharmGKB ID | PA134711056 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2238444 |
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