|
|
|
|
|
Diphenoxylate
drug data and news
Diphenoxylate drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
|
| Generic name | Diphenoxylate | ||
| Brand Names/Synonyms | Dea No. 9170; Difenossilato [Dcit]; Difenoxilato [Inn-Spanish]; Difenoxilato [Spanish]; Diphenoxalate; Diphenoxylate; Diphenoxylate Hydrochloride; Diphenoxylate-Atropine; Diphenoxylatum [Inn-Latin]; Diphenoxylatum [Latin]; HSDB 3067; Lomotil; R 1132; R-1132 | ||
| Indication | For as adjunctive therapy in the management of diarrhea | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Diphenoxylate, an antidiarrheal, is effective as adjunctive therapy in the management of diarrhea. Diphenoxylate is rapidly and extensively metabolized in man by ester hydrolysis to diphenoxylic acid (difenoxine), which is biologically active and the major metabolite in the blood. | ||
| Mechanism Of Action | Diphenoxylate is an opiate receptor agonists that stimulate mu receptors in GI to decrease the peristalsis and constrict the sphincters. Diphenoxylate has a direct effect on circular smooth muscle of the bowel, that conceivably results in segmentation and prolongation of gastrointestinal transit time. The clinical antidiarrheal action of diphenoxylate may thus be a consequence of enhanced segmentation that allows increased contact of the intraluminal contents with the intestinal mucosa. | ||
| Diphenoxylate News (When available) |
Fired campus bus driver had history of auto accidents Nov 16, 2005 HEALTH WARNINGS FOR TRAVELERS' Sep 13, 2005 Four Local Dentists Disciplined By Licensing Board Aug 4, 2005 Bonds' doc on probation, was disciplined twice May 5, 2005 | ||
| Dosage Forms | Oral Solution; Tablet | ||
| Drug_Category | Narcotics; Antidiarrheals; Antiperistaltic; ATC:A07DA01 | ||
| Absorption | 90% | ||
| Interactions |
Interactions for Diphenoxylate: Known drug interactions include barbiturates, tranquilizers, and alcohol. Diphenoxylate HCl and atropine sulfate may interact with MAO inhibitors In studies with male rats, diphenoxylate hydrochloride was found to inhibit the hepatic microsomal enzyme system at a dose of 2 mg/kg/day. Therefore, diphenoxylate has the potential to prolong the biological half-lives of drugs for which the rate of elimination is dependent on the microsomal drug metabolizing enzyme system. | ||
| Toxicity | Coma, dry skin and mucous membranes, enlarged pupils of the eyes, extremely high body temperature, flushing, involuntary eyeball movement, lower than normal muscle tone, pinpoint pupils, rapid heartbeat, restlessness, sluggishness, suppressed breathing | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | ethyl 1-(3-cyano-3,3-diphenyl-propyl)-4-phenyl-piperidine-4-carboxylate | ||
| Chemical Formula | C30H32N2O2 | ||
| Molecular Weight | 452.587 g/mol | ||
| Smiles String | CCOC(=O)C1(CCN(CC1)CCC(C#N)(C2=CC=CC=C2)C3=CC=CC=C3)C4=CC=CC=C4 | ||
| Melting Point | 221 °C | ||
| Water Solubility | 0.8 mg/ml | ||
| State | Solid | ||
| LogP/Hphobicity | 7.385 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Hepatic | ||
| Half Life | 12-14 hours | ||
| Protein Binding [%] | 74-95% | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference | http://www.rxlist.com/cgi/generic3/diphenoxylate.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00366 | ||
| CAS Registry Number | 915-30-0 | ||
| KEGG Compound ID | D00301 | ||
| PubChem ID | SID:10074 | ||
| PharmGKB ID | Not Available | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | Not Available |
|
Home | About | Cancers | Treatment | Medications Copyright onconews.org 2005. All Rights Reserved. |