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Digibind
drug data and news
Digibind drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
Digibind
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| Brand Names/Synonyms |
Ig gamma-2A chain C region, A allele; DigiBind |
| Indication |
For treatment of digitoxin overdose or digitalis glycoside toxicity |
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Description |
Sheep antibody (26-10) FAB fragment specific to Digoxin (MW=46.2 kD) |
| Pharmacology |
DigiFab binds molecules of digoxin, making them unavailable for binding at their site of action on cells in the body. The Fab fragment-digoxin complex accumulates in the blood, from which it is excreted by the kidney. The net effect is to shift the equilibrium away from binding of digoxin to its receptors in the body, thereby reversing its effects. |
| Mechanism Of Action |
Binds excess digoxin or digitoxin molecules circulating in the blood. |
Digibind News
(When available) |
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| Dosage Forms |
Not Available |
| Drug_Category |
Digoxin Antidote |
| Absorption |
Not Available |
| Interactions |
Not Available |
| Toxicity |
Not Available |
| Organisms Affected |
Humans and other mammals |
| Chemical IUPAC Name |
Anti-digoxin antibody fragment |
| Chemical Formula |
C6394H9908N1698O2011S58 >Anti-digoxin 26-10 Light chain 1 >Anti-digoxin 26-10 Heavy chain 2 >Anti-digoxin 26-10 Light chain 2 |
| Molecular Weight |
144602.257 |
| Smiles String |
Not Available |
| Melting Point |
61 oC (FAB fragment)-Vermeer, A.W.P. & Norde, W., Biophys. J. 78:394-404 (2000). |
| Water Solubility |
Not Available |
| State |
Transparent, slightly viscous, aqueous liquid |
| LogP/Hphobicity |
-0.385 |
| Isoelectric Point |
7.03 |
| Biotransformation |
Not Available |
| Half Life |
1 hours (mammalian reticulocytes, in vitro) |
| Protein Binding [%] |
Not Available |
| RxList Link |
RXlist |
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| Drug Reference |
http://www.rxlist.com/cgi/generic3/digoxinfab.htm |
| Drug Type |
Approved Drug |
| Accession No |
BIOD00027 |
| CAS Registry Number |
Not Available |
| KEGG Compound ID |
Not Available |
| PubChem ID |
Not Available |
| PharmGKB ID |
PA449319 |
| SwissProt ID |
GCAA_MOUSE (P01863) |
| GenBank ID |
V00798 |
| Drug ID Number [DIN] |
Not Available
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