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Dicyclomine
drug data and news
Dicyclomine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Dicyclomine | ||
| Brand Names/Synonyms | Atumin; Bentomine; Bentyl; Bentyl Hydrochloride; Bentylol; Bentylol Hydrochloride; CHEMBANK819; Di-Syntramine; Dicicloverina [Inn-Spanish]; Dicyclomine; Dicyclomine Hcl; Dicyclomine Hydrochloride; Dicycloverin; Dicycloverin Hydrochloride; Dicycloverine; Dicycloverine Hydrochloride; Dicycloverinum [Inn-Latin]; Diethylaminocarbethoxybicyclohexyl Hydrochloride; Diocyl; Diocyl Hydrochloride; Dyspas; Formulex; HSDB 3058; Kolantyl Hydrochloride; Mamiesan; Merbentyl; Oxityl-P; Procyclomin; Sawamin; Spasmoban; Wyovin; Wyovin Hydrochloride | ||
| Indication | For the treatment of functional bowel/irritable bowel syndrome including Colicky abdominal pain;Diverticulitis | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Dicyclomine is an anticholinergic drug, a medication that reduces the effect of acetylcholine, a chemical released from nerves that stimulates muscles, by blocking the receptors for acetylcholine on smooth muscle (a type of muscle). It also has a direct relaxing effect on smooth muscle. Dicyclomine is used to treat or prevent spasm in the muscles of the gastrointestinal tract in the irritable bowel syndrome. In addition, Dicyclomine inhibits gastrointestinal propulsive motility and decreases gastric acid secretion and controls excessive pharyngeal, tracheal and bronchial secretions. | ||
| Mechanism Of Action | Action is achieved via a dual mechanism: (1) a specific anticholinergic effect (antimuscarinic) at the acetylcholine-receptor sites and (2) a direct effect upon smooth muscle (musculotropic). | ||
| Dicyclomine News (When available) |
Researchers Identify First Compound To Block Progression Of ... Mar 5, 2006 Experimental Drug Reverses Key Cognitive Deficits, Pathology In ... Mar 4, 2006 Drug Found to Reverse the Ravages of Alzheimer's in Mice Mar 1, 2006 From the analyst's couch: The IBS market Feb 15, 2006 Irritable Bowel Syndrome (The Noisy Rumbling Tummy) Sep 16, 2005 STRONG MEDICINE NEEDED FOR OUT-OF-CONTROL IRRITABLE BOWEL SYNDROME Aug 9, 2005 James Le Fanu finds out what works for colicky cryers, while ... Mar 29, 2005 Inappropriate medication prescribed to elderly Mar 8, 2005 Almost One In Three Seniors Given Inappropriate Meds Feb 26, 2005 Almost One In Three Seniors Given Inappropriate Meds Feb 25, 2005 | ||
| Dosage Forms | CAPSULE | ||
| Drug_Category | Anticholinergic Agents; Antispasmodics; Antimuscarinics; Antispasmodics; ATC:A03BA | ||
| Absorption | Not Available | ||
| Interactions |
Interactions for Dicyclomine: The following agents may increase certain actions or side effects of anticholinergic drugs. amantadine antiarrhythmic agents of class (e.g. quinidine), antihistamines antipsychotic agents (e.g. phenothiazines), benzodiazepines. MAO inhibitors, narcotic analgesics (e.g., meperidine), nitrates and nitrites, sympathomimetic agents, tricyclic antidepressants, and other drugs having anticholinergic activity. Anticholinergics antagonize the effects of antiglaucoma agents. Anticholinergic drugs in the presence of increased intraocular pressure may be hazardous when taken concurrently with agents such as corti costeroids.. Anticholinergic agents may affect gastrointestinal absorption of various drugs, such as slowly dissolving dosage forms of digoxin; increased serum digoxin concentrations may result. Anticholinergic drugs may antagonize the effects of the drugs that alter gastrointestinal motility, such as metoclopramide. Because antacids may interfere with the absorption of anticholinergic agents, simultaneous use of these drugs should be avoided. The inhibiting effects of anticholinergic drugs on gastric hydrochloric acid secretion are antagonized by agents used to treat achlorhydria and those used to test gastric secretion. | ||
| Toxicity | Not Available | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 2-diethylaminoethyl1-cyclohexylcyclohexane-1-carboxylate | ||
| Chemical Formula | C19H35NO2 | ||
| Molecular Weight | 309.487 g/mol | ||
| Smiles String | CCN(CC)CCOC(=O)C1(CCCCC1)C2CCCCC2 | ||
| Melting Point | Not Available | ||
| Water Solubility | Not Available | ||
| State | Solid | ||
| LogP/Hphobicity | 5.476 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Not Available | ||
| Half Life | Not Available | ||
| Protein Binding [%] | >99% | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Dicyclomine.html http://www.rxlist.com/cgi/generic/dicyc.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00113 | ||
| CAS Registry Number | 77-19-0 | ||
| KEGG Compound ID | C06951 | ||
| PubChem ID | SID:9166 | ||
| PharmGKB ID | PA449299 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 392820 |
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