Dicyclomine drug data and news

Dicyclomine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name Dicyclomine
Brand Names/Synonyms Atumin; Bentomine; Bentyl; Bentyl Hydrochloride; Bentylol; Bentylol Hydrochloride; CHEMBANK819; Di-Syntramine; Dicicloverina [Inn-Spanish]; Dicyclomine; Dicyclomine Hcl; Dicyclomine Hydrochloride; Dicycloverin; Dicycloverin Hydrochloride; Dicycloverine; Dicycloverine Hydrochloride; Dicycloverinum [Inn-Latin]; Diethylaminocarbethoxybicyclohexyl Hydrochloride; Diocyl; Diocyl Hydrochloride; Dyspas; Formulex; HSDB 3058; Kolantyl Hydrochloride; Mamiesan; Merbentyl; Oxityl-P; Procyclomin; Sawamin; Spasmoban; Wyovin; Wyovin Hydrochloride
Indication For the treatment of functional bowel/irritable bowel syndrome including Colicky abdominal pain;Diverticulitis
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Description Not Available
Pharmacology Dicyclomine is an anticholinergic drug, a medication that reduces the effect of acetylcholine, a chemical released from nerves that stimulates muscles, by blocking the receptors for acetylcholine on smooth muscle (a type of muscle). It also has a direct relaxing effect on smooth muscle. Dicyclomine is used to treat or prevent spasm in the muscles of the gastrointestinal tract in the irritable bowel syndrome. In addition, Dicyclomine inhibits gastrointestinal propulsive motility and decreases gastric acid secretion and controls excessive pharyngeal, tracheal and bronchial secretions.
Mechanism Of Action Action is achieved via a dual mechanism: (1) a specific anticholinergic effect (antimuscarinic) at the acetylcholine-receptor sites and (2) a direct effect upon smooth muscle (musculotropic).
Dicyclomine News
(When available)

Researchers Identify First Compound To Block Progression Of ...  Mar 5, 2006
The mice were injected with AF267B or with a compound called dicyclomine, which is an M1 antagonist and performs exactly the opposite function of an M1 agonist ... - Science Daily (press release)

Experimental Drug Reverses Key Cognitive Deficits, Pathology In ...  Mar 4, 2006
...the central role of M1 receptors in AD-like pathology, the researchers also tested the effects on the mice of another drug, dicyclomine, that blocks M1 ... - Medical News Today (press release),

Drug Found to Reverse the Ravages of Alzheimer's in Mice  Mar 1, 2006
The team additionally found that suppressing the M1 receptors with a drug called dicyclomine exacerbated learning and memory impairment in the Alzheimer's mice ... - Scientific American

From the analyst's couch: The IBS market  Feb 15, 2006
...c and antidiarrhoeal agents such as loperamide for IBS-d. The pain associated with IBS can be addressed with antispasmodics such as dicyclomine and hyoscyamine ... - Nature.com (subscription),

Irritable Bowel Syndrome (The Noisy Rumbling Tummy)  Sep 16, 2005
Where the person has cramps, anti-spasmodic agents such as Hyoscine compounds (Buscopan): mebeverine, dicyclomine are useful in relaxing the bowel smooth ... - The Guardian - Nigeria,

STRONG MEDICINE NEEDED FOR OUT-OF-CONTROL IRRITABLE BOWEL SYNDROME  Aug 9, 2005
...diarrhea. What medicines has she tried? Dicyclomine can sometimes control the erratic intestinal muscle contractions of IBS. Loperamide ... - Charlotte Sun-Herald,

James Le Fanu finds out what works for colicky cryers, while ...  Mar 29, 2005
The only truly effective remedy, the antispasmodic drug, dicyclomine, can regrettably no longer be prescribed, which means that parents must soldier on with ... - Telegraph.co.uk,

Inappropriate medication prescribed to elderly  Mar 8, 2005
The medications cited as ''Always avoid'' are: barbiturates, belladonna alkaloids, chlorpropamide, dicyclomine, flurazepam, hyoscyamine, meperidine, meprobamate ... - Helena Independent Record,

Almost One In Three Seniors Given Inappropriate Meds  Feb 26, 2005
...the study showed that at least 1 percent of the seniors received the antispasmodic drugs belladonna alkaloids, hyoscyamine and dicyclomine, all three of which ... - RedNova.com,

Almost One In Three Seniors Given Inappropriate Meds  Feb 25, 2005
...the study showed that at least 1 percent of the seniors received the antispasmodic drugs belladonna alkaloids, Hyoscyamine and Dicyclomine, all three of which ... - drkoop.com

Dosage Forms CAPSULE
Drug_Category Anticholinergic Agents; Antispasmodics; Antimuscarinics; Antispasmodics; ATC:A03BA
Absorption Not Available
Interactions Interactions for Dicyclomine:

The following agents may increase certain actions or side effects of anticholinergic drugs. amantadine antiarrhythmic agents of class (e.g. quinidine), antihistamines antipsychotic agents (e.g. phenothiazines), benzodiazepines. MAO inhibitors, narcotic analgesics (e.g., meperidine), nitrates and nitrites, sympathomimetic agents, tricyclic antidepressants, and other drugs having anticholinergic activity.

Anticholinergics antagonize the effects of antiglaucoma agents. Anticholinergic drugs in the presence of increased intraocular pressure may be hazardous when taken concurrently with agents such as corti costeroids..

Anticholinergic agents may affect gastrointestinal absorption of various drugs, such as slowly dissolving dosage forms of digoxin; increased serum digoxin concentrations may result.

Anticholinergic drugs may antagonize the effects of the drugs that alter gastrointestinal motility, such as metoclopramide. Because antacids may interfere with the absorption of anticholinergic agents, simultaneous use of these drugs should be avoided.

The inhibiting effects of anticholinergic drugs on gastric hydrochloric acid secretion are antagonized by agents used to treat achlorhydria and those used to test gastric secretion.

Toxicity Not Available
Organisms Affected Humans and other mammals
Chemical IUPAC Name 2-diethylaminoethyl1-cyclohexylcyclohexane-1-carboxylate
Chemical Formula C19H35NO2
Molecular Weight 309.487 g/mol
Smiles String CCN(CC)CCOC(=O)C1(CCCCC1)C2CCCCC2
Melting Point Not Available
Water Solubility Not Available
State Solid
LogP/Hphobicity 5.476
Isoelectric Point Not Available
Biotransformation Not Available
Half Life Not Available
Protein Binding [%] >99%
RxList Link RXlist
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Drug Reference http://www.drugs.com/cons/Dicyclomine.html
http://www.rxlist.com/cgi/generic/dicyc.htm
Drug Type Approved Drug
Accession No APRD00113
CAS Registry Number 77-19-0
KEGG Compound ID C06951
PubChem ID SID:9166
PharmGKB ID PA449299
SwissProt ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] 392820

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