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Dicumarol
drug data and news
Dicumarol drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
Dicumarol
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| Brand Names/Synonyms |
Acadyl; Acavyl; Antitrombosin; BHC; Baracoumin; Bis-Hydroxycoumarin; Bishydroxycoumarin; Cuma; Cumid; Dicoumal; Dicoumarin; Dicoumarol; Dicuman; Dicumaol R; Dicumarine; Dicumarol; Dicumol; Dikumarol; Dufalone; Kumoran; Melitoxin; Temparin; Trombosan |
| Indication |
For decreasing blood clotting |
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Description |
Not Available |
| Pharmacology |
Dicumarol is an coumarin-like compound found in sweet clover. It is used as an oral anticoagulant and acts by inhibiting the hepatic synthesis of vitamin K-dependent coagulation factors (prothrombin and factors VII, IX, and X). It is also used in biochemical experiments as an inhibitor of reductases. |
| Mechanism Of Action |
Dicumarol inhibits vitamin K reductase, resulting in depletion of the reduced form of vitamin K (vitamin KH2). As vitamin K is a cofactor for the carboxylation of glutamate residues on the N-terminal regions of vitamin K-dependent proteins, this limits the gamma-carboxylation and subsequent activation of the vitamin K-dependent coagulant proteins. The synthesis of vitamin K-dependent coagulation factors II, VII, IX, and X and anticoagulant proteins C and S is inhibited. Depression of three of the four vitamin K-dependent coagulation factors (factors II, VII, and X) results in decresed prothrombin levels and a decrease in the amount of thrombin generated and bound to fibrin. This reduces the thrombogenicity of clots. |
Dicumarol News
(When available) |
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| Dosage Forms |
Not Available |
| Drug_Category |
Uncoupling Agents; Anticoagulants; Enzyme Inhibitors; ATC:B02 |
| Absorption |
Not Available |
| Interactions |
Not Available |
| Toxicity |
Oral, mouse LD50: 233 mg/kg; Oral, rat LD50: 250 mg/kg |
| Organisms Affected |
Humans and other mammals |
| Chemical IUPAC Name |
2-hydroxy-3-[(2-hydroxy-4-oxo-chromen-3-yl)methyl]chromen-4-one |
| Chemical Formula |
C19H12O6 |
| Molecular Weight |
336.295 g/mol |
| Smiles String |
C1=CC=C2C(=C1)C(=O)C(=C(O2)O)CC3=C(OC4=CC=CC=C4C3=O)O |
| Melting Point |
290 °C |
| Water Solubility |
128 mg/L |
| State |
Solid (powder) |
| LogP/Hphobicity |
3.447 |
| Isoelectric Point |
Not Available |
| Biotransformation |
Not Available |
| Half Life |
Not Available |
| Protein Binding [%] |
Not Available |
| RxList Link |
Not Available>RXlist |
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| Drug Reference |
http://www.drugs.com/cons/Dicumarol.html |
| Drug Type |
Approved Drug |
| Accession No |
APRD00761 |
| CAS Registry Number |
66-76-2 |
| KEGG Compound ID |
C00796 |
| PubChem ID |
SID:4054 |
| PharmGKB ID |
PA449298 |
| SwissProt ID |
Not Available |
| GenBank ID |
Not Available |
| Drug ID Number [DIN] |
Not Available
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