|
|
|
|
|
Dichlorphenamide
drug data and news
Dichlorphenamide drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
|
| Generic name | Dichlorphenamide | ||
| Brand Names/Synonyms | Antidrasi; CB 8000; CHEMBANK2570; Daranide; Dasanide; Dichlofenamide; Dichlorophenamide; Dichlorphenamid; Dichlorphenamide; Dichlorphenamide [Ban]; Diclofenamida [Inn-Spanish]; Diclofenamide; Diclofenamidum [Inn-Latin]; Glaucol; HSDB 3267; Oratrol | ||
| Indication | For adjunctive treatment of: chronic simple (open-angle) glaucoma, secondary glaucoma, and preoperatively in acute angle-closure glaucoma where delay of surgery is desired in order to lower intraocular pressure | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Dichlorphenamide is an oral carbonic anhydrase inhibitor indicated for adjunctive treatment of: chronic simple (open-angle) glaucoma, secondary glaucoma, and preoperatively in acute angle-closure glaucoma where delay of surgery is desired in order to lower intraocular pressure. Carbonic anhydrase inhibitors reduce intraocular pressure by partially suppressing the secretion of aqueous humor (inflow). | ||
| Mechanism Of Action | Carbonic anhydrase inhibitors reduce intraocular pressure by partially suppressing the secretion of aqueous humor (inflow), although the mechanism by which they do this is not fully understood. Evidence suggests that HCO3- ions are produced in the ciliary body by hydration of carbon dioxide under the influence of carbonic anhydrase and diffuse into the posterior chamber which contains more Na+ and HCO3- ions than does plasma and consequently is hypertonic. Water is then attracted to the posterior chamber by osmosis, resulting in a drop in pressure. | ||
| Dichlorphenamide News (When available) |
| ||
| Dosage Forms | Not Available | ||
| Drug_Category | Antiglaucomic Agents; Ophthalmics; ATC:S01EC02 | ||
| Absorption | Not Available | ||
| Interactions |
Interactions for Dichlorphenamide: Caution is advised in patients receiving concomitant high-dose aspirin and carbonic anhydrase inhibitors, as anorexia, tachypnea, lethargy and coma have been rarely reported due to a possible drug interaction. | ||
| Toxicity | Not Available | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 4,5-dichlorobenzene-1,3-disulfonamide | ||
| Chemical Formula | C6H6Cl2N2O4S2 | ||
| Molecular Weight | 305.16 g/mol | ||
| Smiles String | C1=C(C=C(C(=C1S(=O)(=O)N)Cl)Cl)S(=O)(=O)N | ||
| Melting Point | 228.7 °C | ||
| Water Solubility | Not Available | ||
| State | Solid | ||
| LogP/Hphobicity | 0.37 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Not Available | ||
| Half Life | Not Available | ||
| Protein Binding [%] | 55% | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Dichlorphenamide.html http://www.rxlist.com/cgi/generic/dichlorphen.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00131 | ||
| CAS Registry Number | 120-97-8 | ||
| KEGG Compound ID | C07459 | ||
| PubChem ID | SID:9662 | ||
| PharmGKB ID | PA449292 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | Not Available |
|
Home | About | Cancers | Treatment | Medications Copyright onconews.org 2005. All Rights Reserved. |