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Diazepam
drug data and news
Diazepam drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Diazepam | ||
| Brand Names/Synonyms | Alboral; Aliseum; Alupram; Amiprol; An-Ding; Ansiolin; Ansiolisina; Apaurin; Apo-Diazepam; Apozepam; Armonil; Assival; Atensine; Atilen; Bensedin; Bialzepam; CB 4261; Calmocitene; Calmpose; Cercine; Ceregulart; Condition; DAP; Diacepan; Dialag; Dialar; Diapam; Diastat; Diazemuls; Diazemulus; Diazepa&Laquo;Mu&Raquo;; Diazepam; Diazepam Intensol; Diazepan; Diazetard; Dienpax; Dipam; Dipezona; Dizac; Domalium; Duksen; Duxen; E-Pam; Eridan; Eurosan; Evacalm; Faustan; Faustan,; Freudal; Frustan; Gewacalm; Gihitan; Horizon; Kabivitrum; Kiatrium; LA 111; LA III; La-Iii; Lamra; Lembrol; Levium; Liberetas; Mandrozep; Methyldiazepinone; Methyldiazepinone, Pharmaceutical; Morosan; Neurolytril; Noan; Novazam; Novo-Dipam; Paceum; Pacitran; Paranten; Paxate; Paxel; Plidan; Pms-Diazepam; Pro-Pam; Q-Pam; Q-Pam Relanium; Quetinil; Quiatril; Quievita; Relaminal; Relanium; Relax; Renborin; Ruhsitus; S.A. R.L.; Saromet; Sedapam; Sedipam; Seduksen; Seduxen; Serenack; Serenamin; Serenzin; Servizepam; Setonil; Sibazon; Sibazone; Solis; Sonacon; Stesolid; Stesolin; Tensopam; Tranimul; Tranqdyn; Tranquase; Tranquirit; Tranquo-Puren; Tranquo-Tablinen; Umbrium; Unisedil; Usempax Ap; Valaxona; Valeo; Valiquid; Valitran; Valium; Valrelease; Vatran; Velium; Vival; Vivol; Wy 3467; Wy-3467; Zetran; Zipan | ||
| Indication | For use as Sedative-hypnotic, antiaxiety and antidepressant | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Diazepam, a benzodiazepine, generates the same active metabolite as chlordiazepoxide and clorazepate. Diazepam is an antianxiety agent, sedative, amnestic, anticonvulsant, skeletal muscle relaxant, and anesthetic adjunct, and is used in the treatment of alcohol withdrawal, status epilepticus, and febrile seizures. | ||
| Mechanism Of Action | Benzodiazepines bind nonspecifically to benzodiazepine receptors BNZ1, which mediates sleep, and BNZ2, which affects affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABAA) receptors, this enhances the effects of GABA by increasing GABA affinity for the GABA receptor. Binding of GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell. | ||
| Diazepam News (When available) |
AT THE COURTHOUSE Mar 2, 2006 Coroner: Chris Penn died accidentally Feb 13, 2006 Chris Penn died accidentally from enlarged heart, medicine mix Feb 13, 2006 Enlarged heart, meds mix found in Penn death Feb 14, 2006 Chris Penn's death ruled accidental Feb 14, 2006 Coroner: Chris Penn's Death Accidental Feb 13, 2006 Chris Penn’s toxicology report revealed Feb 22, 2006 Indian Pharma going strong in third quarter Feb 23, 2006 When Abroad, Beware of Drug Name Confusion Feb 8, 2006 Penn's death accidental - coroner Feb 13, 2006 Coroner: Chris Penn Died Of Enlarged Heart Feb 13, 2006 Big Heart, Drug Cocktail Caused Penn's Death Feb 14, 2006 Coroner: Chris Penn's Death an Accident Feb 14, 2006 Coroner's report on Penn's death released Feb 14, 2006 A friend in need Feb 16, 2006 LA Coroner rules that Chris Penn's death was an accident Feb 15, 2006 Chris Penn's life, and tragic death Feb 18, 2006 When Abroad, Beware of Drug Name Confusion Feb 8, 2006 Local briefs Jan 20, 2006 TT & Zydus Q3 results Jan 29, 2006 Hall Sheriff reflects on loss of deputy Jan 10, 2006 Deputy in good condition after wreck Jan 18, 2006 Cadila gets US FDA approval for Promethazine tablets Nov 20, 2005 Cadila gets US FDA approval for Promethazine tablets Nov 20, 2005 Cadila gets USFDA nod for Promethazine tablets Nov 20, 2005 Cadila gets US FDA approval for Promethazine tablets Nov 20, 2005 Cadila Healthcare gets USFDA approval for Promethazine Nov 21, 2005 Cadila gets US FDA approval for Promethazine tablets Nov 21, 2005 Cadila wins approval for anti-emetic drug Nov 21, 2005 Cadila Healthcare receives approval from US FDA Nov 21, 2005 Indian shares ease, Colombo extends slide Nov 20, 2005 Indices finally stump the uprising on profit booking Nov 21, 2005 Pharmacists convicted of conspiring to illegally distribute ... Oct 4, 2005 Borden Wrongful Death Lawsuit Dismissed Against TASER(TM) ... Oct 26, 2005 A traffic stop led to convictions of 6 who illegally dispensed ... Oct 8, 2005 Pharmacists doled out gallons of drug so abused that Houston is ... Oct 4, 2005 6 pharmacists convicted in cough-syrup ring Oct 4, 2005 Six pharmacists convicted in cough syrup abuse case Oct 4, 2005 Six pharmacists convicted in cough syrup abuse case Oct 4, 2005 Austin doctor, previously disciplined, caused patient's death ... Oct 10, 2005 My Philosophy Sep 29, 2005 Austin doctor, previously disciplined, caused patient's death ... 11 Oct 2005 A traffic stop led to convictions of 6 who illegally dispensed ... Oct 8, 2005 Pharmacists convicted of conspiring to illegally distribute ... Oct 4, 2005 Pharmacists doled out gallons of drug so abused that Houston is ... Oct 4, 2005 6 pharmacists convicted in cough-syrup ring Oct 4, 2005 Six pharmacists convicted in cough syrup abuse case Oct 4, 2005 Six pharmacists convicted in cough syrup abuse case Oct 4, 2005 DEA shuts 4,600 rogue pharmacy sites Sep 27, 2005 Crackdown targets Web drug sales Sep 22, 2005 My Philosophy Sep 29, 2005 | ||
| Dosage Forms | tablets, injectable solution | ||
| Drug_Category | Anesthetics; Anti-anxiety Agents; Muscle Relaxants; Hypnotics and Sedatives; Antiemetics; Anticonvulsants; Adjuvants; Benzodiazepines; ATC:N05BA01; ATC:N05BA17 | ||
| Absorption | 93% | ||
| Interactions |
-->Interactions for Diazepam: No information provided.
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| Toxicity | Somnolence, confusion, coma, and diminished reflexes. Respiration, pulse and blood pressure should be monitored | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 10-chloro-6-methyl-2-phenyl-3,6-diazabicyclo[5.4.0]undeca-2,8,10,12-tetraen-5-one | ||
| Chemical Formula | C16H13ClN2O | ||
| Molecular Weight | 284.74 g/mol | ||
| Smiles String | CN1C(=O)CN=C(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3 | ||
| Melting Point | 125-126°C | ||
| Water Solubility | Slightly soluble | ||
| State | solid | ||
| LogP/Hphobicity | 2.988 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | hepatic | ||
| Half Life | Not Available | ||
| Protein Binding [%] | 98.50% | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Diazepam.html http://www.rxlist.com/cgi/generic/diazepam.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00642 | ||
| CAS Registry Number | 439-14-5 | ||
| KEGG Compound ID | C06948 | ||
| PubChem ID | SID:153142 | ||
| PharmGKB ID | PA449283 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2247176 |
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