Dextromethorphan drug data and news

Dextromethorphan drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name Dextromethorphan
Brand Names/Synonyms &Laquo;Delta&Raquo;-Methorphan; Antussan; Ba 2666; Balminil Dm; Balminil Dm Children; Benylin Adult Formula Cough Suppressant; Benylin Dm; Benylin Dm 12 Hour; Benylin Dm for Children; Benylin Dm for Children 12 Hour; Benylin Pediatric Cough Suppressant; Calmylin #1; Canfodion; Cosylan; Cough-X; Creo-Terpin; D-Methorphan; D-Methorphan Hydrobromide; Dea No. 9210; Delsym; Delsym Cough Formula; Delta-Methorphan; Demorphan; Demorphan Hydrobromide; Demorphine; Destrometerfano [Dcit]; Dextromethorfan; Dextromethorfan [Czech]; Dextromethorphan; Dextromethorphan Bromhydrate; Dextromethorphan Bromide; Dextromethorphan [Ban:Inn]; Dextrometorfano [Inn-Spanish]; Dextrometorphan; Dextromorphan; Dexyromethorphan; Diabe-Tuss Dm Syrup; Dormetan; Dormethan; Hihustan M.; Hold Dm; Koffex Dm; L-Methorphan; Levomethorphan; Levomethorphan [Ban:Dcf:Inn]; Levomethorphane [Inn-French]; Levomethorphanum [Inn-Latin]; Levometorfano [Inn-Spanish]; Medicon; Methorate Hydrobromide; Methorphan; Metrorat; Novahistex Dm; Novahistine Dm; Pertussin Cs Children's Strength; Pertussin Dm Extra Strength; Racemethorphan [As D-Form]; Robitussin Maximum Strength Cough Suppressant; Robitussin Pediatric; Robitussin Pediatric Cough Suppressant; Romilar; Sucrets 4 Hour Cough Suppressant; Triaminic Dm Long Lasting for Children; Trocal; Tusilan; Tussade; Vicks 44 Cough Relief
Indication For treatment and relief of dry cough
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Description Not Available
Pharmacology Suppresses the cough reflex by a direct action on the cough center in the medulla of the brain.
Mechanism Of Action Dextromethorphan is an opioid-like drug that binds to and acts as antagonist to the NMDA glutamatergic receptor, it is an agonist to the opioid sigma 1 and sigma 2 receptors, it is also an alpha3/beta4 nicotinic receptor antagonist and targets the serotonin reuptake pump. Dextromethorphan is rapidly absorbed from the gastrointestinal tract, where it enters the bloodstream and crosses the blood-brain barrier. The first-pass through the hepatic portal vein results in some of the drug being metabolized into an active metabolite of dextromethorphan, dextrorphan, the 3-hydroxy derivative of dextromethorphan.
Dextromethorphan News
(When available)

Teens getting high from easy to access pharmaceuticals  06 Mar 2006
Among these products are those that feature dextromethorphan (DXM), common in cold and cough suppressants such as Robitussin or cough drops. ... - Middletown Press,

Turn Your Head and Cough  Feb 20, 2006
According to the ACCP, over the counter (OTC) cough remedies containing dextromethorphan (listed as DM on most cough medicines) don't work for adults and are ... - TCS Daily,

What's with all the coughing?  Mar 3, 2006
Although Americans spent nearly $270 million per year on cough syrup containing the suppressant dextromethorphan and/or guaifenesin, an expectorant, several ... - Monterey County Herald,

Not what the doctor ordered  Mar 3, 2006
On that Saturday afternoon last fall, Adam purposely ingested 300 milligrams of Dextromethorphan (DXM), the non-narcotic cough suppressant active in over 140 ... - Silver Chips Online,

FDA Joins Investigation of Infants’ Deaths Believed to Have Been ...  Feb 26, 2006
...children 12 months and younger — in whose systems were found such common cold-fighting components as pseudoephedrine, dextromethorphan and acetaminophen.�. ... - Newsinferno.com,

Nothing to cough at  Feb 19, 2006
...have been at least 90 overdoses in the state during the past year from people drinking large amounts of cough syrup containing the compound dextromethorphan. ... - Enid News & Eagle,

District continues to worry about cough pills  Feb 27, 2006
Dextromethorphan — also called DXM, tussin, dex and robo by users — is a cough suppressant that causes a high in large doses, typically five times the ... - Waxahachie Daily Light,

4 medical myths are debunked  Mar 2, 2006
Chest, chest doctors who reviewed scores of studies concluded that there is no scientific evidence that suppressants, such as dextromethorphan, or expectorants ... - Louisville Courier-Journal,

News you can use  Feb 28, 2006
SUPPRESSANT: A dry cough needs to be stopped because it can cause hoarseness and irritation. Nonproductive coughs need an antitussive such as dextromethorphan. ... - Augusta Chronicle (subscription),

AAFES restricts purchase medicines containing DXM  Feb 10, 2006
DALLAS -- Dextromethorphan (DXM) is a common cough-suppressing ingredient contained in more than 140 over-the-counter cough and cold medicines. ... - The Beam,

Focus Of Legislation: Teens Getting High On Cough Syrup  Feb 13, 2006
...the state during the past year from drinking excessive amounts of cough syrup, including Robitussin DM, containing the compound dextromethorphan, the measure's ... - Channel Oklahoma.com,

Young getting high on cough syrup  Feb 19, 2006
...without a prescription. "Kafosed contains dextromethorphan hydrobromide, 15mg per 5ml," said Ms Abdulwahab. "The adverse effects ... - Gulf Daily News,

New Guidelines Say Cough Medicines Don’t Help  Feb 8, 2006
A common over-the-counter cough suppressant is dextromethorphan, and the only expectorant available over the counter is guaifenesin. ... - Diabetes Self Management

Disturbing drug trend invades Murphy  Feb 22, 2006
Dextromethorphan (DXM), the drug found in Robitussin and countless other cough suppressants, is essentially used to control cough reflexes. ... - Cherokee Sentinel,

If syrup is sullied, how do we conquer a cough?  Feb 21, 2006
According to the American College of Chest Physicians, most over-the-counter cough syrups, usually containing the cough suppressant dextromethorphan and the ... - Canton Repository (subscription),

House OKs ban on pure form of DXM  Feb 23, 2006
Dextromethorphan, or DXM, is found in more than 140 over-the-counter cough medicines, according to the National Drug Intelligence Center, part of the US ... - Urbana/Champaign News-Gazette,

Coping with coughing  Feb 15, 2006
New guidelines from the specialists say that dextromethorphan -- the active ingredient in many cough syrups -- never has been proven to relieve cough caused by ... - South Bend Tribune,

Teens getting high on cough syrup focus of legislation  Feb 13, 2006
Nance says at least 90 overdoses have been reported in the state during the past year from drinking excessive amounts of cough syrup containing dextromethorphan ... - KTEN,

warning on cough medicines  Feb 7, 2006
These ingredients include guaifenesin (found in Robitussin and other cough remedies) and dextromethorphan (found in Robitussin, Vicks, Triaminic, Sucrets and ... - NorthJersey.com,

New guidelines issued by physicians pit common sense against ...  Feb 4, 2006
Even more worrisome, state health-care professionals have seen a rise in the number of drug-abuse cases involving dextromethorphan (DXM), an ingredient found ... - Houston Chronicle,

AAFES putting age limit on sale of some over-the-counter cough ...  Feb 4, 2006
Dextromethorphan is an ingredient contained in more than 140 over-the-counter cough and cold medicines, including Coricidin, Robitussin DM, and Vicks 44. ... - Stars and Stripes,

A Warning For Parents  Feb 14, 2006
They can be just as addictive and very dangerous.". Dextromethorphan, or DXM, is the active ingredient in medications like Coricidin and Robitussin. ... - WCIV,

THE WOLVERINES LAIR: Schools, society and drugs  Feb 3, 2006
DXM, or dextromethorphan, is the latest in a long line of drugs promising euphoria only to deliver dizziness, vomiting, diarrhea, fever, a racing pulse, and ... - Willits News,

Need help surfing cold and flu medicines?  Feb 1, 2006
...or aspirin; sinus medications include a decongestant such as pseudoephedrine or phenylephrine; and cough remedies contain the cough suppressant dextromethorphan ... - South Bend Tribune,

Avanir submits expanded application for Neurodex  Jan 31, 2006
The company says its new application provides additional clinical data showing that Neurodex, a combination of dextromethorphan and quinidine, is safe and ... - Pharmaceutical Business Review

Dosage Forms SYRUP
Drug_Category Antitussives; Analgesics; Antitussives; ATC:R05DA09
Absorption Not Available
Interactions Not Available
Toxicity Not Available
Organisms Affected Humans and other mammals
Chemical IUPAC Name Not Available
Chemical Formula C18H25NO
Molecular Weight 271.397 g/mol
Smiles String CN1CCC23CCCCC2C1CC4=C3C=C(C=C4)OC
Melting Point Not Available
Water Solubility Not Available
State Solid
LogP/Hphobicity 4.323
Isoelectric Point Not Available
Biotransformation Not Available
Half Life Not Available
Protein Binding [%] Not Available
RxList Link Not Available>RXlist
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Drug Reference http://www.drugs.com/cons/Dextromethorphan.html
Drug Type Approved Drug
Accession No APRD00655
CAS Registry Number 125-71-3
KEGG Compound ID C06947
PubChem ID SID:173392
PharmGKB ID PA449273
SwissProt ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] 816000

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