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Dexbrompheniramine
drug data and news
Dexbrompheniramine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Dexbrompheniramine | ||
| Brand Names/Synonyms | Antihistamine Compound; BROMPHENIRAMINE; Bromfeniramina [Inn-Spanish]; Bromopheniramine; Brompheniraminum [Inn-Latin]; D-Brompheniramine; Dexbrompheniramine; Dimetane; Disomer; HSDB 3017; Ilvin; Parabromdylamine; Parabromodylamine | ||
| Indication | For treatment and relief of symptoms of allergies, hay fever, and colds | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H1-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Dexbrompheniramine is a histamine H1 antagonist (or more correctly, an inverse histamine agonist) of the alkylamine class. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies. | ||
| Mechanism Of Action | Dexbrompheniramine competitively binds to the histamine H1-receptor. It competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine. | ||
| Dexbrompheniramine News (When available) |
Cough Meds -- What Works May 11, 2006 | ||
| Dosage Forms | TABLET | ||
| Drug_Category | Antihistamines; ATC:R06AB06 | ||
| Absorption | Antihistamines are well absorbed from the gastrointestinal tract after oral administration. | ||
| Interactions |
Interactions for Dexbrompheniramine: Dexbrompheniramine can interact with alcohol or other CNS depressants (may potentiate the CNS depressant effects of either these medications or antihistamines), anticholinergics or other medications with anticholinergic activity (anticholinergic effects may be potentiated when these medications are used concurrently with antihistamines), and monoamine oxidase (MAO) inhibitors (concurrent use with antihistamines may prolong and intensify the anticholinergic and CNS depressant effects of antihistamines). | ||
| Toxicity | Signs of an overdose include fast or irregular heartbeat, mental or mood changes, tightness in the chest, and unusual tiredness or weakness. | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-yl-propan-1-amine | ||
| Chemical Formula | C16H19BrN2 | ||
| Molecular Weight | 319.24 g/mol | ||
| Smiles String | CN(C)CCC(C1=CC=C(C=C1)Br)C2=CC=CC=N2 | ||
| Melting Point | Not Available | ||
| Water Solubility | Not Available | ||
| State | Solid | ||
| LogP/Hphobicity | 3.74 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Hepatic (cytochrome P-450 system), some renal. | ||
| Half Life | 25 hours | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference | Not Available | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00770 | ||
| CAS Registry Number | 132-21-8 | ||
| KEGG Compound ID | Not Available | ||
| PubChem ID | SID:271487 | ||
| PharmGKB ID | PA449250 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 411892 |
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