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Desmopressin acetate
drug data and news
Desmopressin acetate drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
Desmopressin acetate
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| Brand Names/Synonyms |
Stimate |
| Indication |
For treatment of diabetes insipidus, prevention of polydipsia, polyuria and dehydration |
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Description |
A synthetic analogue of the natural pituitary hormone 8-arginine vasopressin (ADH), an antidiuretic hormone affecting renal water conservation. Synthetic peptide with 3-mercaptopropionic acid replacing the N-terminal Cysteine and D-Arg replacing Arg: |
| Pharmacology |
Increases plasma levels of Factor VIII in patients with mild hemophilia A and von Willebrands disease (Type 1). The cellular mechanism is not yet clear. |
| Mechanism Of Action |
Binds to the vasopressin V2 receptor which leads to exocytosis from Weibel Palade bodies where both VWF and t-PA are stored, as well as to nitric oxide (NO) production via activation of endothelial NO synthase. |
Desmopressin acetate News
(When available) |
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| Dosage Forms |
TABLET |
| Drug_Category |
Antidiuretic Agents; pituitary (68:28.00) |
| Absorption |
Not Available |
| Interactions |
Not Available |
| Toxicity |
Not Available |
| Organisms Affected |
Humans and other mammals |
| Chemical IUPAC Name |
Desmopressin acetate |
| Chemical Formula |
C68H102N22O20S2 |
| Molecular Weight |
1611.8 |
| Smiles String |
Not Available |
| Melting Point |
Not Available |
| Water Solubility |
Not Available |
| State |
Transparent, slightly viscous, aqueous liquid |
| LogP/Hphobicity |
-1.129 |
| Isoelectric Point |
7.98 |
| Biotransformation |
Not Available |
| Half Life |
Not Available |
| Protein Binding [%] |
Not Available |
| RxList Link |
RXlist |
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| Drug Reference |
http://www.rxlist.com/cgi/generic3/desmoprt.htm |
| Drug Type |
Approved Drug |
| Accession No |
BIOD00061 |
| CAS Registry Number |
16679-58-6 |
| KEGG Compound ID |
C06944 |
| PubChem ID |
9159 |
| PharmGKB ID |
PA449237 |
| SwissProt ID |
Not Available |
| GenBank ID |
Not Available |
| Drug ID Number [DIN] |
2246500
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