Desipramine drug data and news

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Treating ADD With Medication  06 Mar 2006
...include atomoxetine, known as Stratera; buproprion, known as Wellbutrin; clonidine, known as Catapres; imipramine, known as Tofranil; and desipramine, known as ... - DailyIndia.com,

Characteristics and Regulation of 123 I-MIBG Transport in Cultured ...  Mar 1, 2006
The uptake 1 inhibitors desipramine, imipramine, and phenoxybenzamine at 50 µmol/L reduced 123 I-MIBG uptake to 55.3% ± 2.7%, 62.4% ± 3.5%, and 48.0% ± 2.2 ... - Journal of Nuclear Medicine

Trimipramine for Refractory Panic Attacks  Mar 2, 2006
...alprazolam. Quetiapine had to be discontinued because of gastrointestinal side effects. Desipramine was started at 10 mg at bedtime. The ... - Am J Psychiatry (subscription)

Early response to anti-bulimia drug a good sign  Feb 10, 2006
Health) - Women with the binge and purge eating disorder, bulimia nervosa, who respond to treatment with the antidepressant desipramine (Norpramin) within the ... - Reuters.uk,

Early response to bulimia drug 'a good sign'  Feb 11, 2006
New York - Women with the binge and purge eating disorder, bulimia nervosa, who respond to treatment with the anti-depressant desipramine (Norpramin) within ... - Independent Online,

Popular Antidepressants Boost Brain Growth, Hopkins Scientists ...  Feb 6, 2006
...serotonin reuptake enhancer tianeptine (a drug approved for human use only in France) or the selective norepineprine reuptake inhibitor desipramine, a so ... - Johns Hopkins Gazette,

US and Foreign Drug Names  Feb 22, 2006
In the United States, Norpramin is the brand name for an antidepressive drug containing desipramine, but in Spain, Norpramin is the name of a drug that ... - Journal of American Medical Association (subscription),

When Abroad, Beware of Drug Name Confusion  Feb 8, 2006
...ingredients. For example, in the United States, Norpramin is the brand name of the drug desipramine, which is prescribed for depression. ... - Diabetes Self Management

Health Tip: Drugs to Avoid While Breast-Feeding  Feb 16, 2006
Antidepressant drugs: Amitriptyline, Amoxapine, Bupropion, Clomipramine, Desipramine, Dothiepin, Doxepin, Fluoxetine, Fluvoxamine, Imipramine, Nortriptyline ... - Forbes

Brain white-matter hyperintensities and treatment outcome in major ...  Feb 8, 2006
Fava, M., Alpert, J., Nierenberg, AA, et al (2002) Double-blind study of high-dose fluoxetine versus lithium or desipramine augmentation of fluoxetine in ... - British Journal of Psychiatry (subscription),

From the analyst's couch: The IBS market  Feb 15, 2006
In addition, low-dose tricyclic antidepressants such as amitriptyline and desipramine have also found utility in treating a variety of IBS-related symptoms. ... - Nature.com (subscription),

When Abroad, Beware of Drug Name Confusion  Feb 8, 2006
...ingredients. For example, in the United States, Norpramin is the brand name of the drug desipramine, which is prescribed for depression. ... - Diabetes Self Management

Popular Antidepressants Boost Brain Growth, Hopkins Scientists ...  Feb 6, 2006
...serotonin reuptake enhancer tianeptine (a drug approved for human use only in France) or the selective norepineprine reuptake inhibitor desipramine, a so ... - Johns Hopkins Gazette,

Continuity of Antidepressant Treatment for Adults With Depression ...  Jan 24, 2006
...health maintenance organization who were initially treated with fluoxetine were more likely than patients treated with imipramine or desipramine to continue ... - Am J Psychiatry (subscription)

Brief Reports: Patterns of Psychotropic Medication Use by Race ...  Jan 25, 2006
Tricyclics included ami-triptyline, amitriptyline pamoate, clomi-pramine, desipramine, doxepin, imipramine, nortriptyline, protriptyline, trimipramine, and ... - Psychiatric Services (subscription)

FDA Cautions Consumers Against Filling US Prescriptions Abroad  Jan 12, 2006
In the United States, "Norpramin" is the brand name for an anti-depression drug containing desipramine but, in Spain, the same brand name, "Norpramin," is used ... - Community Dispatch (press release)

Leptin Acts as Rodent Antidepressant  Jan 16, 2006
They were compared with control rats (injected with saline) and with rats who were treated with Norpramin (desipramine), a medication used as an antidepressant ... - MedPage Today,

FDA warns against buying prescription drugs on the net or overseas  Jan 17, 2006
..."Norpramin" in the US is the brand name for an anti-depression drug containing desipramine but, in Spain, the same brand name, "Norpramin," is a drug that ... - News-Medical.net,

New Updates in Chronic Constipation and Irritable Bowel Syndrome  Dec 6, 2005
...since the publication of this review, Drossman and colleagues [55] have demonstrated the efficacy of the tricyclic antidepressant desipramine in treating ... - Medscape (subscription)

The Surgeon General's Report on Mental Health  Nov 30, 2005
Walsh, BT, Giardina, EG, Sloan, RP, Greenhill, L., & Goldfein, J. (1994). Effects of desipramine on autonomic control of the heart. ... - About - News & Issues,

Depressive Symptoms and 24-Hour Urinary Norepinephrine Excretion ...  Nov 13, 2005
EC, Murburg MM, Ashleigh EA, Castillo S, Peskind ER, et al: Sympathetic nervous system activity in major depression: basal and desipramine-induced alterations ... - Am J Psychiatry (subscription)

Evaluation of Reboxetine, a Noradrenergic Antidepressant, for the ...  Sep 23, 2005
N, Bokan JA, Phillips M, Benedetti C, Butler S, Spengler D: Antidepressants in concomitant chronic back pain and depression: doxepin and desipramine compared. ... - Psychosomatics (subscription)

Prevalence and Treatment of Depression in Parkinson’s Disease  Sep 24, 2005
...these receptors. The TCAs include the following: amitriptyline, nortriptyline, imipramine, desipramine, and doxepine. These medications ... - Journal of Neuropsychiatry (subscription)

Behavioral and Pharmacologic Treatment of Aggression in Children ...  Oct 3, 2005
Gordon CT, State RC, Nelson JF et al. (1993), A double-blind comparison of clomipramine, desipramine, and placebo in the treatment of autistic disorder. ... - Psychiatric Times,

Getting an Edge — Use of Stimulants and Antidepressants in ...  Sep 16, 2005
...of drugs; Strattera (atomoxetine), a presynaptic norepinephrine-reuptake inhibitor, and antidepressants such as Norpramin (desipramine), Effexor (venlafaxine ... - New England Journal of Medicine (subscription),

Many meds don't mix with the sun  Sep 21, 2005
Amitriptyline (Elavil), amoxapine (Asendin), bupropion (Wellbutrin), citalopram (Celexa), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Sinequan ... - Pioneer Press,

Evaluation of Reboxetine, a Noradrenergic Antidepressant, for the ...  Sep 6, 2005
N, Bokan JA, Phillips M, Benedetti C, Butler S, Spengler D: Antidepressants in concomitant chronic back pain and depression: doxepin and desipramine compared. ... - Psychosomatics (subscription)

Helping kids with ADHD  Aug 17, 2005
Dexamphetamine. When these medications are not effective, other drugs such as Imipramine, Clonidine, Moclobemide and Desipramine are used. ... - Malaysia Star,

The Hard Work of Growing Up With ADHD  Aug 31, 2005
...antidepressant morphing into an ADHD superhero because of its low potential for cardiotoxicity but, at best, quashing only its closest rival desipramine. ... - Am J Psychiatry (subscription)

2-on-2 league plays for 1  Aug 12, 2005
He says Courtney had been taking two antidepressants, Desipramine and Zoloft, for six to eight months. “She always said it made her feel better,� he says. ... - Portland Tribune,

Smoke, in many forms, endangers the fetus  Aug 3, 2005
Tricyclic antidepressants like amitriptyline, nortriptiline and desipramine were found to be effective in treating postherpetic pain. ... - International Herald Tribune

The Federal Trade Commission Approves Novartis AG’s Acquisition ...  Jul 19, 2005
...consent order with the Commission, Novartis is required to divest all the assets necessary to manufacture and market generic desipramine hydrochloride tablets ... - PharmaLive.com (press release)

UPDATE 1-US FTC OKs Novartis acquisition of Eon Labs  Jul 19, 2005
Commission said it would not oppose the deal after Novartis agreed to sell all the assets needed to make and sell generic desipramine hydrochloride tablets ... - Reuters

Best Treatments for Lasting Shingles Pain  Jul 25, 2005
Those shown effective for postherpetic neuralgia include nortriptyline (Pamelor), desipramine (Norpramin), and amitriptyline (Elavil, Endep). Strong opioids. ... - WebMD

Novartis receives FTC OK for Eon buy  Jul 19, 2005
Federal Trade Commission said it would not stand in the deal's way so long as Novartis sells assets to make and market generic desipramine hydrochloride tablets ... - BusinessWeek

Antidepressants: 1st Choice for Nerve Pain  Jul 19, 2005
...relief. These include medications such as amitriptyline, imipramine, clomipramine, desipramine, and nortriptyline. Anticonvulsant ... - FOX News

Novartis Receives US Regulatory Approval for Completion of Eon ...  Jul 19, 2005
Pursuant to the Consent Decree, Novartis will divest three generic pharmaceutical products, Desipramine HCl, Orphenadrine Citrate ER and Rifampin, the ... - ArriveNet (press release)

Novartis Divests to Get Eon  Jul 19, 2005
Jersey . The drugs Desipramine HCI, Orphenadrine Citrate ER, and Rifampin brought in an estimated $5 million in sales in 2004. With ... - Red Herring

Acute Akathisia Associated With Quetiapine Use  Jul 6, 2005
53 There have been multiple case reports of akathisia induced by nortriptyline, 53 imipramine, 54 and desipramine. 54 A review by Vandel et al. ... - Psychosomatics (subscription)

Why is my child like that?  Jul 16, 2005
Now, the pharmaceutical market is saturated with options: Adderall, Concerta, Focalin, Ritalin, Wellbutrin, Desipramine and Imipramine are among them. ... - Edmond Sun <**results**>

Acute Akathisia Associated With Quetiapine Use  Jul 6, 2005
53 There have been multiple case reports of akathisia induced by nortriptyline, 53 imipramine, 54 and desipramine. 54 A review by Vandel et al. ... - Psychosomatics (subscription)

Advances in Pharmacogenomics Reduce Side Effects and Save Lives  Jul 5, 2005
...study, known as the Pharmacogenetics of Antidepressant Treatment Response in Mexican-Americans (PATRIMA), involving fluoxetine and desipramine (Norpramine). ... - Psychiatric Times

Symptoms of Late-Life Depression Frequency and Change During ...  Jun 14, 2005
17,18 found eight symptoms on the Yale Depression Inventory (YDI) that were frequent and that changed in direct relation to desipramine plasma concentrations. ... - Am J Geriatric Psychiatry (subscription)

Psychopharmacology of Autism Spectrum Disorders  Jun 20, 2005
Gordon CT, State RC, Nelson JE et al. (1993), A double-blind comparison of clomipramine, desipramine, and placebo in the treatment of autistic disorder. ... - Psychiatric Times,

1. Drugs Metabolized by P450 2D6: The biochemical activity of the drug metabolizing isozyme cytochrome P450 2D6 (debrisoquin hydroxylase) is reduced in a subset of the caucasian population (about 7 to 10% of caucasians are so called "poor metabolizers"); reliable estimates of the prevalence of reduced P450 2D6 isozyme activity among Asian, African and other populations are not yet available. Poor metabolizers have higher than expected plasma concentrations of tricyclic antidepressants (TCAs) when given usual doses. Depending on the traction of drug metabolized by P450 2D6, the increase in plasma concentration may be small, or quite large (8 fold increase in plasma AUC of the TCA).

In addition, certain drugs inhibit the activity of this isozyme and make normal metabolizers resemble p.o. metabolizers. An individual who is stable on a given dose of TCA may become abruptly toxic when given one of these inhibiting drugs as concomitant therapy. The drugs that inhibit cytochrome P450 2D6 include some that are not metabolized by the enzyme (quinidine; cimetidine) and many that are substrates for P450 2D6 (many other antidepressants, phenothiazines, and the Type 1C antiarrhythrnics propatenone and flecainide). While all the selective serotonin reuptake inhibitors (SSRIs), e.g., fluoxetine, seriraline, and paroxetine, inhibit P450 2D6, they may vary in the extent of inhibition. The extent to which SSRI-TCA interactions may pose clinical problems will depend on the degree of inhibition and the pharmacokinetics of the SSRI involved. Nevertheless, caution is indicated in the co-administration of T.A. with any of the SSRIs and also in switching from one class to the other. Of particular importance, sufficient time must elapse before initiating TCA treatment in a patient being withdrawn from fluoxetine, given the long half-life of the parent and active metabolite (at least 5 weeks may be necessary).

Concomitant use of tricyclic antidepressants with drugs that can inhibit cytochrome P450 2D6 may require lower doses than usually prescribed for either the tricyclic antidepressant or the other drug. Furthermore, whenever one of these other drugs is withdrawn from co-therapy, an increased dose of tricyclic antidepressant may be required. It is desirable to monitor TCA plasma levels whenever a TCA is going to be co-administered with another drug known to be an inhibitor of P450 2D6.

2. Close supervision and careful adjustment of dosage are required when this drug is given concomitantly with anticholinergic or sympathomimetic drugs.

3. Clinical experience in the concurrent administration of ECT and antidepressant drugs is limited. Thus, if such treatment is essential, the possibility of increased risk relative to benefits should be considered.

4. If desipramine hydrochloride is to be combined with other psychotropic agents such as tranquilizers or sedative/hypnotics, careful consideration should be given to the pharmacology of the agents employed since the sedative effects of desipramine and benzodiazepines (e.g., chlordiazepoxide or diazepam) are additive. Both the sedative and anticholinergic effects of the major tranquilizers are also additive to those of desipramine.

5. Concurrent administration of cimetidine and tricyclic antidepressants can produce clinically significant increases in the plasma levels of the tricyclic antidepressants. Conversely, decreases in plasma levels of the tricyclic antidepressants have been reported upon discontinuation of cimetidine which may result in the loss of the therapeutic efficacy of the tricyclic antidepressant

6. There have been greater than two-fold increases of previously stable plasma levels of tricyclic antidepressants when fluoxetine has been administered in combination with these agents.