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Delavirdine
drug data and news
Delavirdine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Delavirdine | ||
| Brand Names/Synonyms | BHAP-U 90152; Bhap Der; DLV; Delavirdine; Rescriptor; SPP | ||
| Indication | For the treatment of HIV-1 infection in combination with appropriate antiretroviral agents when therapy is warranted | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Delavirdine is a non-nucleoside reverse transcriptase inhibitor (nNRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Delavirdine binds directly to reverse transcriptase (RT) and blocks the RNA-dependent and DNA-dependent DNA polymerase activities by causing a disruption of the enzyme's catalytic site. The activity of Delavirdine does not compete with template or nucleoside triphosphates. HIV-2 RT and eukaryotic DNA polymerases (such as human DNA polymerases alpha, beta, or sigma) are not inhibited by Delavirdine. | ||
| Mechanism Of Action | Delavirdine binds directly to viral reverse transcriptase (RT) and blocks the RNA-dependent and DNA-dependent DNA polymerase activities by disrupting the enzyme's catalytic site. | ||
| Delavirdine News (When available) |
Multi-component drug delivery system: An emerging trend Feb 8, 2006 Multi-component drug delivery system: An emerging trend Feb 8, 2006 T-20 helps to prevent mother-to-child transmission of HIV in women ... Jan 19, 2006 Lexiva for the treatment of HIV infection in adults in combination ... Jan 19, 2006 Psychiatric Manifestations of HIV Infection and AIDS Dec 5, 2005 FDA Approves Updated Labeling for LEXIVA Nov 18, 2005 Anti-HIV drug from rainforest almost lost before its discovery Sep 13, 2005 IAS: The New York Patient - source found but mysteries remain Jul 26, 2005 Study Results Presented on Pharmacokinetics of Once-Daily HIV ... Jul 26, 2005 HAART & the Molecular Biology of AIDS Dementia Complex May 20, 2005 | ||
| Dosage Forms | caplets | ||
| Drug_Category | Anti-HIV Agents; Nonnucleoside Reverse Transcriptase Inhibitors; ATC:J05AG02 | ||
| Absorption | rapidly absorbed | ||
| Interactions | Antiacid, clarithromycin, Didanosine, Fluconazole, Fluoxetine, Indanavir, Ketoconazole, Phenytoin, Phenobarbitol, carbamazepine, Rifabutin, Rifampin, Ritanovir, Saquinavir. | ||
| Toxicity | Major toxicity of RESCRIPTOR is rash and should be advised to promptly notify their physician should rash occur. The majority of rashes associated with RESCRIPTOR occur within 1 to 3 weeks after initiating treatment with RESCRIPTOR. The rash normally resolves in 3 to 14 days and may be treated symptomatically while therapy with RESCRIPTOR is continued. Any patient experiencing severe rash or rash accompanied by symptoms such as fever, blistering, oral lesions, conjunctivitis, swelling, muscle or joint aches should discontinue medication and consult a physician. | ||
| Organisms Affected | Human immunodeficiency virus | ||
| Chemical IUPAC Name | N-[2-[4-[3-(1-methylethylamino)pyridin-2-yl]piperazin-1-yl]carbonyl-1H-indol-5-yl]methanesulfonamide | ||
| Chemical Formula | C22H28N6O3S | ||
| Molecular Weight | 456.562 g/mol | ||
| Smiles String | CC(C)NC1=C(N=CC=C1)N2CCN(CC2)C(=O)C3=CC4=C(N3)C=CC(=C4)NS(=O)(=O)C | ||
| Melting Point | 226-228 °C | ||
| Water Solubility | Not Available | ||
| State | solid | ||
| LogP/Hphobicity | 2.926 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | hepatic | ||
| Half Life | 5.8 hours | ||
| Protein Binding [%] | 98% | ||
| RxList Link | Not Available>RXlist | ||
| Sponsored links | |||
| Drug Reference | http://www.drugs.com/cons/Delavirdine.html | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00149 | ||
| CAS Registry Number | 136817-59-9 | ||
| KEGG Compound ID | C06941 | ||
| PubChem ID | SID:206947 | ||
| PharmGKB ID | PA449223 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2238348 |
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