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Dacarbazine
drug data and news
Dacarbazine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Dacarbazine | ||
| Brand Names/Synonyms | Biocarbazine R; DIC; DTIC; DTIE; Dacarbazine; Dacarbazino [Inn-Spanish]; Dacarbazinum [Inn-Latin]; Deticene; Dimethyltriazenoimidazolecarboxamide; Dtic-Dome; ICDMT; ICDT; Imidazole Carboxamide | ||
| Indication | For the treatment of metastatic malignant melanoma. In addition, DTIC-Dome is also indicated for Hodgkin's disease as a secondary-line therapy when used in combination with other effective agents | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | After intravenous administration of DTIC-Dome, the volume of distribution exceeds total body water content suggesting localization in some body tissue, probably the liver. Its disappearance from the plasma is biphasic with initial half-life of 19 minutes and a terminal half-life of 5 hours. 1 In a patient with renal and hepatic dysfunctions, the half-lives were lengthened to 55 minutes and 7.2 hours. 1 The average cumulative excretion of unchanged DTIC in the urine is 40% of the injected dose in 6 hours. 1 DTIC is subject to renal tubular secretion rather than glomerular filtration. At therapeutic concentrations DTIC is not appreciably bound to human plasma protein. | ||
| Mechanism Of Action | Possibly blocking the formation of inosinic acid. | ||
| Dacarbazine News (When available) |
International Approvals: Alertec, Multiferon, Alvesco Feb 27, 2006 Neoadjuvant Chemotherapy and Radiotherapy Promising for Large Soft ... Mar 3, 2006 Viragen's Multiferon Approved in Sweden for First-Line Adjuvant ... Feb 21, 2006 Viragen's Multiferon approved in Sweden Feb 22, 2006 Neoadjuvant Sarcoma Chemotherapy Results in High Toxicity Levels Mar 1, 2006 Bilateral adrenal masses: phaeochromocytoma or melanoma? Feb 28, 2006 Genasense(R) New Drug Application Accepted for Review by FDA Mar 1, 2006 Randomized Trial Shows Ganite(R) Effective When Compared with a ... Mar 2, 2006 Metastatic Melanoma Responds to Taxol® and Paraplatin® Feb 16, 2006 Results show Genta's cancer drug is effective Feb 3, 2006 Patients With Newly Diagnosed Glioblastoma Multiforme - Health ... Feb 6, 2006 International Approvals: Cubicin and Temodal Feb 6, 2006 Genasense(R) Marketing Authorization Application in Melanoma ... Feb 1, 2006 Analysis of Genasense(R) Trial Confirms Major Efficacy Variables ... Feb 2, 2006 Garden State Business Briefs Feb 2, 2006 Highlights of rising and falling US stocks Feb 2, 2006 | ||
| Dosage Forms | LIQUID; POWDER FOR SOLUTION | ||
| Drug_Category | Antineoplastic Agents; ATC:L01AX04 | ||
| Absorption | Erratic, slow and incomplete | ||
| Interactions |
Interactions for Dacarbazine: No Information Provided. | ||
| Toxicity | LD50=350mg/kg (orally in mice) | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 5-dimethylaminoazo-3H-imidazole-4-carboxamide | ||
| Chemical Formula | C6H10N6O | ||
| Molecular Weight | 182.183 g/mol | ||
| Smiles String | CN(C)N=NC1=C(NC=N1)C(=O)N | ||
| Melting Point | 205 °C | ||
| Water Solubility | 4220 mg/L | ||
| State | Solid | ||
| LogP/Hphobicity | -1.938 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Hepatic | ||
| Half Life | 5 hours | ||
| Protein Binding [%] | <5% | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Dacarbazine.html http://www.rxlist.com/cgi/generic2/dacarbazine.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00331 | ||
| CAS Registry Number | 3/4/4342 | ||
| KEGG Compound ID | C06936 | ||
| PubChem ID | SID:163170 | ||
| PharmGKB ID | PA449197 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2241445 |
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