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Cyclosporine
drug data and news
Cyclosporine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Cyclosporine | ||
| Brand Names/Synonyms | Gengraf; Sandimmune; Neoral; Restasis; Gengraf (Abbott labs); Sandimmune (Novartis); Neoral (Novartis); Restasis (Allergan Inc) | ||
| Indication | For treatment of transplant rejection, rheumatoid arthritis, severe psoriasis | ||
| Sponsored links | Description | 11 amino acid cyclic peptide. It is produced as a metabolite by the fungus species Beauveria nlyea. | |
| Pharmacology | Used in immunosuppression for prophylactic treatment of organ transplants, cyclosporine exerts specific and reversible inhibition of immunocompetent lymphocytes in the G0-or G1-phase of the cell cycle. T-lymphocytes are preferentially inhibited. The T1-helper cell is the main target, although the T1-suppressor cell may also be suppressed. Sandimmune (cyclosporine) also inhibits lymphokine production and release including interleukin-2. | ||
| Mechanism Of Action | Cyclosporine binds to cyclophillin. The complex then inhibits calcineurin which is normally responsible for activating transcription of interleukin 2. Cyclosporine also inhibits lymphokine production and ineterluekin relase. | ||
| Cyclosporine News (When available) |
Euroshares open lower after Wall St losses, oils and miners fall ... 07 Mar 2006 Tokyo shares finish lower on softer Wall St, monetary policy ... 07 Mar 2006 Swiss shares fall in quiet morning trade as Wall St losses weigh 07 Mar 2006 Euroshares open lower after Wall St losses, utilities still in ... 07 Mar 2006 Tokyo shares end morning lower on weaker Wall St; caution ahead of ... 07 Mar 2006 Chemical spill forces the evacuation of a St. Charles business 07 Mar 2006 Madrid shares close flat on mixed Wall St; blue chips weak ... 07 Mar 2006 Breaking News: St. Vincent Govt. Press Sect. Found Dead 07 Mar 2006 Thieves Break Into East St. Louis Evidence Room 07 Mar 2006 New ST clinches semis slot 07 Mar 2006 Ex-St. Joe's Prep player charged 07 Mar 2006 College Roundup: St. A's Moore is NE-10 MVP 07 Mar 2006 St. Mary's run ends in semis 07 Mar 2006 St. Luke's top 100 again 07 Mar 2006 St. Patrick's Day Parade in Los Angeles 07 Mar 2006 Hong Kong Market Down Sharply On Wall St. Woes 07 Mar 2006 Agency to Close St. Louis Office 07 Mar 2006 City of Columbia departments to move from Laurel St. to Washington ... 07 Mar 2006 Florida St 80, Georgia Tech 79 09 Feb 2006 Butler lifts No. 19 Ohio St. over No. 22 Michigan 09 Feb 2006 Tokyo shares outlook - Weaker on Wall St lead; machinery orders in ... 09 Feb 2006 St. James in Torino 09 Feb 2006 Swiss shares close higher tracking Wall St, led by Syngenta ... 09 Feb 2006 St. Augustine Center Threatened by Financial Crisis 09 Feb 2006 Notre Dame girls stun No.2 St. Francis 09 Feb 2006 Florida 63, Mississippi St. 48 09 Feb 2006 UDM beats Wright St. 09 Feb 2006 Oil prices, earnings lift Wall St. 09 Feb 2006 Gilman St. allegedly home to guns, thugs and drugs 09 Feb 2006 General: Carleton-St. Olaf Day of Charity, 2/9/06 09 Feb 2006 Armed robbery at 4th St. Market...Suspects at large 09 Feb 2006 Wall St. happy to see 30-year bond return 09 Feb 2006 Asian shares close mostly higher tracking Wall St gains 09 Feb 2006 US-131 closed in St. Joseph County 09 Feb 2006 Former TV anchor appointed St. Louis police commissioner 09 Feb 2006 Bunceton 5th-6th grade boys and girls beat St. Joseph Pilot Grove 09 Feb 2006 St. Louis-area layoffs decrease 09 Feb 2006 St. Clair: More facts on restorative dentistry 09 Feb 2006 Updated Village Facts on St. Paul's In the Works 09 Feb 2006 St. Joseph's out-lasts Dutchtown in shootout in District 4-I ... 09 Feb 2006 New Mexico 80, Colorado St. 78 09 Feb 2006 St Cloud couple killed in traffic accident 09 Feb 2006 Parco Foods sold to St. Louis-based Ralcorp Holdings 09 Feb 2006 St. Joseph nips Geibel 09 Feb 2006 Braves Baseball Blanks St. Augustine’s 11-0 09 Feb 2006 Frantic efforts to prevent bauxite strike in St. Ann 09 Feb 2006 | ||
| Dosage Forms | Not Available | ||
| Drug_Category | Immunmodulatory Agents; Immunosupressants | ||
| Absorption | Not Available | ||
| Interactions | Not Available | ||
| Toxicity | Not Available | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | Cyclosporine | ||
| Chemical Formula | C62H111N11O12 | ||
| Molecular Weight | 1202.61 | ||
| Smiles String | CCC1C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1)C(C(C)CC=CC)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C | ||
| Melting Point | Not Available | ||
| Water Solubility | Not Available | ||
| State | Transparent, slightly viscous, aqueous liquid | ||
| LogP/Hphobicity | 4.293 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Not Available | ||
| Half Life | 10-27 hrs | ||
| Protein Binding [%] | 90% | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Cyclosporine.html http://www.rxlist.com/cgi/generic3/restasis.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | BIOD00003 | ||
| CAS Registry Number | 59865-13-3 | ||
| KEGG Compound ID | Not Available | ||
| PubChem ID | SID:199551 | ||
| PharmGKB ID | PA449167 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | Not Available |
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