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Cyclobenzaprine
drug data and news
Cyclobenzaprine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Cyclobenzaprine | ||
| Brand Names/Synonyms | Cyclobenz; Cyclobenzaprine; Cyclobenzaprine Hcl; Flexeril; Flexiban; MK-130; Proeptatriene; Proheptatriene; RP-9715 | ||
| Indication | For use as an adjunct to rest and physical therapy for relief of muscle spasm associated with acute, painful musculoskeletal conditions | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Cyclobenzaprine, closely related to the antidepressant amitriptyline, is used as a skeletal muscle relaxant to reduce pain and tenderness to and improve mobility. Unlike dantrolene, cyclobenzaprine cannot be used to treat muscle spasm secondary to cerebral or spinal cord disease. | ||
| Mechanism Of Action | Like the tricyclic antidepressants, cyclobenzaprine exhibits anticholinergic activity, potentiation of norepinephrine, and antagonism of reserpine. Cyclobenzaprine does not directly act on the neuromuscular junction or the muscle but relieves muscle spasms through a central action, possibly at the brain stem level. Cyclobenzaprine binds to the serotonin receptor and is considered a 5-HT2 receptor antagonist that reduces muscle tone by decreasing the activity of descending serotonergic neurons. | ||
| Cyclobenzaprine News (When available) |
Mylan Announces FDA Approval for Cyclobenzaprine Hydrochloride ... Feb 6, 2006 FDA approves Mylan's cyclobenzaprine Feb 6, 2006 (PRN) - Mylan Announces FDA Approval for Cyclobenzaprine ... Feb 6, 2006 Mylan Announces FDA Approval for Cyclobenzaprine Hydrochloride ... Feb 15, 2006 First-Time Generic Approvals: Flexeril, Plavix, and AndroGel Feb 21, 2006 Mylan wins approval for generic muscle relaxant Feb 6, 2006 Briefs: US Airways traffic falls as it cuts flights Feb 6, 2006 Man arrested, jailed for drugs, firearms, hitting police officer Feb 24, 2006 Mylan Gets FDA OK for Generic Flexeril Feb 6, 2006 Business news briefs: 2/7/06 Feb 6, 2006 Mylan Announces FDA Approval for Cyclobenzaprine Hydrochloride ... Feb 6, 2006 FDA approves Mylan's cyclobenzaprine Feb 6, 2006 (PRN) - Mylan Announces FDA Approval for Cyclobenzaprine ... Feb 6, 2006 Mylan wins approval for generic muscle relaxant Feb 6, 2006 Briefs: US Airways traffic falls as it cuts flights Feb 6, 2006 Mylan Gets FDA OK for Generic Flexeril Feb 6, 2006 Business news briefs: 2/7/06 Feb 6, 2006 Woman sentenced to year in jail Jan 10, 2006 Suppression Of US Marshal’s Statements Halts Trial Jan 19, 2006 DISTRICT COURTS Dec 2, 2005 Man found guilty of drug possession Nov 30, 2005 Evaluation of Reboxetine, a Noradrenergic Antidepressant, for the ... Sep 23, 2005 Toxicology Reports Eyed in Trial of Leroy Charley Sep 30, 2005 McNeil Consumer & Specialty Pharmaceuticals Statement Regarding ... Sep 13, 2005 Expiration Dates Observed on Foods, But Not Always on Medications Sep 20, 2005 McNeil Consumer & Specialty Pharmaceuticals Statement Regarding ... Sep 13, 2005 District Court Report Jul 7, 2005 District Court Report Jul 7, 2005 Data Shows That ADHD Patients on CONCERTA (Methylphenidate HCl) ... Jun 28, 2005 Data Shows That ADHD Patients on CONCERTA(R) (Methylphenidate HCl) ... Jun 28, 2005 | ||
| Dosage Forms | "D"-shaped, film coated tablets | ||
| Drug_Category | Tranquilizing Agents; Muscle Relaxants; Antidepressants; Skeletal Muscle Relaxants; ATC:M03BX08 | ||
| Absorption | Well absorbed after oral administration | ||
| Interactions |
-->Interactions for Cyclobenzaprine: FLEXERIL may have life-threatening interactions with MAO inhibitors. FLEXERIL may enhance the effects of alcohol, barbiturates, and other CNS depressants. Tricyclic antidepressants may block the antihypertensive action of guanethidine and similarly acting compounds. Tricyclic antidepressants may enhance the seizure risk in patients taking tramadol. | ||
| Toxicity | Confusion, disturbed concentration, transient visual hallucinations, agitation, hyperactive reflexes, muscle rigidity, vomiting, or hyperpyrexia, drowsiness, hypothermia, tachycardia and other cardiac rhythm abnormalities such as bundle branch block, ECG evidence of impaired conduction, and congestive heart failure. Other manifestations may be dilated pupils, convulsions, severe hypotension, stupor, and coma. LD50 of cyclobenzaprine HCl is approximately 338 and 425 mg/kg in mice and rats, respectively | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine | ||
| Chemical Formula | C20H21N | ||
| Molecular Weight | 275.387 g/mol | ||
| Smiles String | CN(C)CCC=C1C2=CC=CC=C2C=CC3=CC=CC=C31 | ||
| Melting Point | 216-218oC (HCl salt) | ||
| Water Solubility | freely soluble | ||
| State | Solid | ||
| LogP/Hphobicity | 4.974 | ||
| Isoelectric Point | 8.47 | ||
| Biotransformation | Gastrointestinal and hepatic | ||
| Half Life | 18 hours (range 8-37 hours) | ||
| Protein Binding [%] | Very high 93% | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Cyclobenzaprine.html http://www.rxlist.com/cgi/generic/cyclobnz.htm http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/fle1179.shtml | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00213 | ||
| CAS Registry Number | 303-53-7 | ||
| KEGG Compound ID | C06931 | ||
| PubChem ID | SID:64015 | ||
| PharmGKB ID | PA449160 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2249359 |
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