Cromolyn drug data and news

Cromolyn drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name Cromolyn
Brand Names/Synonyms Aarane; Acide Cromoglicique [Inn-French]; Acido Cromoglicico [Inn-Spanish]; Acidum Cromoglicicum [Inn-Latin]; Alercom; Alerion; Allergocrom; Apo-Cromolyn; Children's Nasalcrom; Colimune; Crolom; Cromoglicic Acid; Cromoglycic Acid; Cromolyn; Cromolyn Nasal Solution; Cromolyn Sodium; Cromoptic; Cromovet; Diethyl Cromoglycicate; Fivent; Gastrocrom; Gastrofrenal; Gen-Cromoglycate; HSDB 3308; Inostral; Intal; Intal Inhaler; Intal Syncroner; Introl; Irtan; Lomudal; Lomupren; Lomusol; Lomuspray; Nalcrom; Nalcron; Nasalcrom; Nasmil; Novo-Cromolyn; Opticrom; Opticron; Pms-Sodium Cromoglycate; Rynacrom; Sodium Cromoglycate; Sofro; Vistacrom; Vividrin
Indication For the management of patients with bronchial asthma. Also used in the treatment of vernal keratoconjunctivitis, vernal conjunctivitis, and vernal keratitis.
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Description Not Available
Pharmacology Cromolyn, a synthetic compound, inhibits antigen-induced bronchospasms and, hence, is used to treat asthma and allergic rhinitis. Cromolyn is used as an ophthalmic solution to treat conjunctivitis and is taken orally to treat systemic mastocytosis and ulcerative colitis.
Mechanism Of Action Cromolyn inhibits degranulation of mast cells, subsequently preventing the release of histamine and slow-reacting substance of anaphylaxis (SRS-A), mediators of type I allergic reactions. Cromolyn also may reduce the release of inflammatory leukotrienes. Cromolyn may act by inhibiting calcium influx.
Cromolyn News
(When available)

Emisphere Technologies Announces Presentation and Webcast at the ...  Mar 1, 2006
...have advanced oral formulations or prototypes of salmon calcitonin, heparin, insulin, parathyroid hormone, human growth hormone and cromolyn sodium into ... - PR Newswire (press release),

Emisphere Technologies Responds to Eli Lilly Motion  Feb 7, 2006
...have advanced oral formulations or prototypes of salmon calcitonin, heparin, insulin, parathyroid hormone, human growth hormone and cromolyn sodium into ... - Yahoo! News (press release)

You can enjoy sex even if you're allergic to it  Jan 27, 2006
If condoms are not an option, the use of an antihistamine or vaginal cromolyn sodium (an allergy medication) will often help, especially if it is a mild case. ... - Chicago Sun-Times,

Red, Itchy, Watery Eyes  Jan 14, 2006
At first only cromolyn sodium was available, but now other options include the prescription drops Acular, Livostin™, and Patanol®, or the over-the-counter ... - About - News & Issues,

Expression of urocortin in rat lung and its effect on pulmonary ...  Jan 11, 2006
Enhanced pulmonary vascular permeability induced by UCN was markedly inhibited by pretreatment with the mast cell stabilizer cromolyn and histamine-1 (H 1 ... - Journal of Endocrinology

Azur Pharma Acquires Gastrocrom(R)  Jan 18, 2006
18 /CNW/ - Azur Pharma Limited ("Azur Pharma") today announced that it has acquired the US rights to Gastrocrom(R) (cromolyn sodium, usp Oral Concentrate) from ... - CNW Telbec (Communiqués de presse),

Azur Pharma Acquires Gastrocrom(R)  Jan 18, 2006
18 /PRNewswire-FirstCall/ -- Azur Pharma Limited ("Azur Pharma") today announced that it has acquired the US rights to Gastrocrom® (cromolyn sodium, usp Oral ... - Yahoo! News (press release)

PEIHRIA - VET'S CORNER  Dec 5, 2005
...g) Miscellaneous = Includes drugs like Cromolyn which inhibits mast cells in the lungs from producing mucus and other secretions. ... - Harnesslink,

Emisphere Technologies Provides 2005 Third Quarter Update  Nov 10, 2005
...have advanced oral formulations or prototypes of salmon calcitonin, heparin, insulin, parathyroid hormone, human growth hormone and cromolyn sodium into ... - PR Newswire (press release),

Treating Asthma  Nov 11, 2005
...an asthma attack. Examples include inhaled corticosteroids, bronchodilators and cromolyn or nedocromil. Quick-relief medications ... - WSOCtv.com,

Emisphere Technologies Announces $15 Million Financing with ...  Sep 26, 2005
...have advanced oral formulations or prototypes of salmon calcitonin, heparin, insulin, parathyroid hormone, human growth hormone and cromolyn sodium into ... - PR Newswire (press release),

Breathing Easier  Sep 26, 2005
Medications approved by the International Olympic Committee for exercise-induced asthma are Albuterol, Tebutaline, Metaproterenol, Cromolyn Sodium and ... - Competitor Magazine,

Nasal Sprays  Sep 24, 2005
There are five main classifications of nasal sprays -- antihistamine, corticosteroid, cromolyn sodium, decongestant, and saline. ... - allergies.about.com

Managing asthma in children  Sep 18, 2005
Cromolyn sodium and nedocromil sodium, in inhaled forms, prevent airways from inflaming when triggers come into contact with them. ... - DetNews.com,

Ah-Ah-Allergies  Sep 12, 2005
...noses. There are also OTC nasal sprays, such as cromolyn sodium, that prevent allergens from entering the body through the nose. ... - Indiana Daily Student

Avoiding exercise-induced asthma  Sep 12, 2005
...should one occur. The medication cromolyn also is an excellent EIA preventive, but it's not for treatment of an acute attack. It's a ... - myDNA.com,

King Pharmaceuticals and Inyx Enter Into Strategic Alliance  08 Sep 2005
...and Inyx, Inc. (BULLETIN BOARD: IYXI) announced today that they have entered into a strategic collaboration relating to Intal(R) (cromolyn sodium) and Tilade(R ... - Finanzen.net,

Emisphere Technologies Presentation at the Oppenheimer Diabetes ...  Sep 1, 2005
...have advanced oral formulations or prototypes of salmon calcitonin, heparin, insulin, parathyroid hormone, human growth hormone and cromolyn sodium into ... - PR Newswire (press release),

A Review of Pregnancy Outcomes After Exposure to Orally Inhaled or ...  Aug 12, 2005
...asthma in the nonpregnant population8, previous evidence-based guidelines for asthma management during pregnancy had recommended inhaled cromolyn as first-line ... - RedNova.com,

Partners in allergy!  Aug 20, 2005
Treatments generally include cromolyn vaginal cream for local reactions and also pre-coital antihistamines to modify the local reactions. ... - Malaysia Star,

Emisphere Technologies Announces 2005 Second Quarter Results  Aug 5, 2005
Emisphere's eligen(R) technology has been used to improve the absorption and bioavailability in humans of small molecules such as cromolyn, and a molecule ... - Forbes

Emisphere Announces Sale of Connecticut Facility  Jul 6, 2005
...have advanced oral formulations or prototypes of salmon calcitonin, heparin, insulin, parathyroid hormone, human growth hormone and cromolyn sodium into ... - Yahoo News (press release)

FDA Advisory Committee  Jul 14, 2005
...metaproterenol), 3M’s Maxair (pirbuterol), Forest’s Aerobid (flunisolide), Kos’ Azmacort (triamcinolone), King’s Intal (cromolyn), Tilade (nedocromil ... - FDA Advisory Committee

FDA Committee To Decide If Azmacort, Alupent, Intal Remain " ...  Jul 13, 2005
...pirbuterol); inhaled corticosteroids from Forest, Aerobid (flunisolide), and Kos Azmacort (triamcinolone); cromones from King, Intal (cromolyn) and Tilade ... - FDA Advisory Committee <**results**>

Changes in Inhaler Devices for Asthma And COPD  Jun 19, 2005
Cromolyn, a unique anti-inflammatory medication, is used for long- term management and prevention of acute bronchospastic episodes. ... Cromolyn inhaler. ... - RedNova.com

Emisphere Announces Sale of Connecticut Facility  Jul 6, 2005
...have advanced oral formulations or prototypes of salmon calcitonin, heparin, insulin, parathyroid hormone, human growth hormone and cromolyn sodium into ... - Yahoo News (press release)

Allergy medications: Know your options  Jun 25, 2005
Available over-the-counter, the nasal spray cromolyn sodium (NasalCrom, Children's NasalCrom) has no serious side effects but may make the nasal passageways ... - MayoClinic.com

Hay fever nothing to sneeze about  Jun 21, 2005
...t like them! Another nose spray, cromolyn sodium (available over the counter), helps prevent allergic reactions. My husband takes ... - The Spokesman Review (subscription),

Dosage Forms CAPSULE; LIQUID; METERED-DOSE (AEROSOL); OINTMENT; POWDER; SOLUTION; SPRAY
Drug_Category Anti-Asthmatic Agents
Absorption 1%
Interactions Interactions for Cromolyn:

Drug Interaction During Pregnancy: Cromolyn sodium and isoproterenol were studied following subcutaneous injections in pregnant mice. Cromolyn sodium alone in doses up to 540 mg/kg/day (approximately 340 times the maximum recommended daily inhalation dose in adults on a mg/m2 basis) did not cause significant increases in resorptions or major malformations. Isoproterenol alone at a dose of 2.7 mg/kg/day (approximately 7 times the maximum recommended daily inhalation dose in adults on a mg/m2 basis) increased both resorptions and malformations. The addition of 540 mg/kg/day of cromolyn sodium (approximately 340 times the maximum recommended daily inhalation dose in adults on a mg/m2 basis) to 2.7 mg/kg/day of isoproterenol (approximately 7 times the maximum recommended daily inhalation dose in adults on a mg/m2 basis) appears to have increased the incidence of both resorptions and malformations.

Toxicity cough, nasal congestion, nausea, sneezing and wheezing
Organisms Affected Humans and other mammals
Chemical IUPAC Name 5-[3-(2-carboxy-4-oxo-chromen-6-yl)oxy-2-hydroxy-propoxy]-4-oxo-chromene-2-carboxylicacid
Chemical Formula C23H16O11
Molecular Weight 468.367 g/mol
Smiles String C1=CC2=C(C(=C1)OCC(COC3=CC4=C(C=C3)OC(=CC4=O)C(=O)O)O)C(=O)C=C(O2)C(=O)O
Melting Point 241-242°C
Water Solubility 210 mg/L
State Solid
LogP/Hphobicity 1.658
Isoelectric Point 1.1
Biotransformation Not Available
Half Life 1.3 hours
Protein Binding [%] Not Available
RxList Link RXlist
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Drug Reference http://www.drugs.com/cons/Cromolyn.html
http://www.rxlist.com/cgi/generic2/cromolyn.htm
Drug Type Approved Drug
Accession No APRD00336
CAS Registry Number 16110-51-3
KEGG Compound ID C06928
PubChem ID SID:170250
PharmGKB ID PA449138
SwissProt ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] 2231671

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