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Cromolyn
drug data and news
Cromolyn drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Cromolyn | ||
| Brand Names/Synonyms | Aarane; Acide Cromoglicique [Inn-French]; Acido Cromoglicico [Inn-Spanish]; Acidum Cromoglicicum [Inn-Latin]; Alercom; Alerion; Allergocrom; Apo-Cromolyn; Children's Nasalcrom; Colimune; Crolom; Cromoglicic Acid; Cromoglycic Acid; Cromolyn; Cromolyn Nasal Solution; Cromolyn Sodium; Cromoptic; Cromovet; Diethyl Cromoglycicate; Fivent; Gastrocrom; Gastrofrenal; Gen-Cromoglycate; HSDB 3308; Inostral; Intal; Intal Inhaler; Intal Syncroner; Introl; Irtan; Lomudal; Lomupren; Lomusol; Lomuspray; Nalcrom; Nalcron; Nasalcrom; Nasmil; Novo-Cromolyn; Opticrom; Opticron; Pms-Sodium Cromoglycate; Rynacrom; Sodium Cromoglycate; Sofro; Vistacrom; Vividrin | ||
| Indication | For the management of patients with bronchial asthma. Also used in the treatment of vernal keratoconjunctivitis, vernal conjunctivitis, and vernal keratitis. | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Cromolyn, a synthetic compound, inhibits antigen-induced bronchospasms and, hence, is used to treat asthma and allergic rhinitis. Cromolyn is used as an ophthalmic solution to treat conjunctivitis and is taken orally to treat systemic mastocytosis and ulcerative colitis. | ||
| Mechanism Of Action | Cromolyn inhibits degranulation of mast cells, subsequently preventing the release of histamine and slow-reacting substance of anaphylaxis (SRS-A), mediators of type I allergic reactions. Cromolyn also may reduce the release of inflammatory leukotrienes. Cromolyn may act by inhibiting calcium influx. | ||
| Cromolyn News (When available) |
Emisphere Technologies Announces Presentation and Webcast at the ... Mar 1, 2006 Emisphere Technologies Responds to Eli Lilly Motion Feb 7, 2006 You can enjoy sex even if you're allergic to it Jan 27, 2006 Red, Itchy, Watery Eyes Jan 14, 2006 Expression of urocortin in rat lung and its effect on pulmonary ... Jan 11, 2006 Azur Pharma Acquires Gastrocrom(R) Jan 18, 2006 Azur Pharma Acquires Gastrocrom(R) Jan 18, 2006 PEIHRIA - VET'S CORNER Dec 5, 2005 Emisphere Technologies Provides 2005 Third Quarter Update Nov 10, 2005 Treating Asthma Nov 11, 2005 Emisphere Technologies Announces $15 Million Financing with ... Sep 26, 2005 Breathing Easier Sep 26, 2005 Nasal Sprays Sep 24, 2005 Managing asthma in children Sep 18, 2005 Ah-Ah-Allergies Sep 12, 2005 Avoiding exercise-induced asthma Sep 12, 2005 King Pharmaceuticals and Inyx Enter Into Strategic Alliance 08 Sep 2005 Emisphere Technologies Presentation at the Oppenheimer Diabetes ... Sep 1, 2005 A Review of Pregnancy Outcomes After Exposure to Orally Inhaled or ... Aug 12, 2005 Partners in allergy! Aug 20, 2005 Emisphere Technologies Announces 2005 Second Quarter Results Aug 5, 2005 Emisphere Announces Sale of Connecticut Facility Jul 6, 2005 FDA Advisory Committee Jul 14, 2005 FDA Committee To Decide If Azmacort, Alupent, Intal Remain " ... Jul 13, 2005 Changes in Inhaler Devices for Asthma And COPD Jun 19, 2005 Emisphere Announces Sale of Connecticut Facility Jul 6, 2005 Allergy medications: Know your options Jun 25, 2005 Hay fever nothing to sneeze about Jun 21, 2005 | ||
| Dosage Forms | CAPSULE; LIQUID; METERED-DOSE (AEROSOL); OINTMENT; POWDER; SOLUTION; SPRAY | ||
| Drug_Category | Anti-Asthmatic Agents | ||
| Absorption | 1% | ||
| Interactions |
Interactions for Cromolyn: Drug Interaction During Pregnancy: Cromolyn sodium and isoproterenol were studied following subcutaneous injections in pregnant mice. Cromolyn sodium alone in doses up to 540 mg/kg/day (approximately 340 times the maximum recommended daily inhalation dose in adults on a mg/m2 basis) did not cause significant increases in resorptions or major malformations. Isoproterenol alone at a dose of 2.7 mg/kg/day (approximately 7 times the maximum recommended daily inhalation dose in adults on a mg/m2 basis) increased both resorptions and malformations. The addition of 540 mg/kg/day of cromolyn sodium (approximately 340 times the maximum recommended daily inhalation dose in adults on a mg/m2 basis) to 2.7 mg/kg/day of isoproterenol (approximately 7 times the maximum recommended daily inhalation dose in adults on a mg/m2 basis) appears to have increased the incidence of both resorptions and malformations. | ||
| Toxicity | cough, nasal congestion, nausea, sneezing and wheezing | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 5-[3-(2-carboxy-4-oxo-chromen-6-yl)oxy-2-hydroxy-propoxy]-4-oxo-chromene-2-carboxylicacid | ||
| Chemical Formula | C23H16O11 | ||
| Molecular Weight | 468.367 g/mol | ||
| Smiles String | C1=CC2=C(C(=C1)OCC(COC3=CC4=C(C=C3)OC(=CC4=O)C(=O)O)O)C(=O)C=C(O2)C(=O)O | ||
| Melting Point | 241-242°C | ||
| Water Solubility | 210 mg/L | ||
| State | Solid | ||
| LogP/Hphobicity | 1.658 | ||
| Isoelectric Point | 1.1 | ||
| Biotransformation | Not Available | ||
| Half Life | 1.3 hours | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Cromolyn.html http://www.rxlist.com/cgi/generic2/cromolyn.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00336 | ||
| CAS Registry Number | 16110-51-3 | ||
| KEGG Compound ID | C06928 | ||
| PubChem ID | SID:170250 | ||
| PharmGKB ID | PA449138 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2231671 |
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