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Collagenase
drug data and news
Collagenase drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Collagenase | ||
| Brand Names/Synonyms | Santyl; Santyl (Advance Biofactures Corp) | ||
| Indication | For treatment of chronic dermal ulcers and severe skin burns | ||
| Sponsored links | Description | The enzyme collagenase is derived from fermentation of Clostridium histolyticum | |
| Pharmacology | Used in the treatment of skin ulcers and sever burns, collagenase is able to digest collagen in necrotic tissue at physiological pH. Collagenase thus contributes towards the formation of granulation tissue and subsequent epithelization of dermal ulcers and severely burned areas. | ||
| Mechanism Of Action | Collagenase is a protease that is specific to collagen. The triple helical region of interstitial collagens is highly resistant to most cell proteinases. However, during remodeling of the connective tissue in such processes as wound healing and metastasis, collagen becomes susceptible to cleavage by collagenases. Collagenase cleaves all 3 alpha helical chains of native Types I, II and III collagens at a single locus by hydrolyzing the peptide bond following the Gly residue of the sequence: Gly 775-(Ile or Leu) 776-(Ala or Leu) 777 located approximately three-fourths of the chain length from each N-terminus | ||
| Collagenase News (When available) |
ECM signals ECM degradation Feb 27, 2006 Tendon Injuries Feb 20, 2006 1 From the Harvard Medical School and Brigham and Women's Hospital ... Feb 17, 2006 | ||
| Dosage Forms | OINTMENT | ||
| Drug_Category | Anti-Ulcer Agents; Topical; misc. skin and mucous membrane agents (84:92.00) | ||
| Absorption | Not Available | ||
| Interactions | Not Available | ||
| Toxicity | Not Available | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | Clostridium histolyticum collagenase | ||
| Chemical Formula | C5028H7666N1300O1564S21 | ||
| Molecular Weight | 112023.2 | ||
| Smiles String | Not Available | ||
| Melting Point | Not Available | ||
| Water Solubility | Not Available | ||
| State | Transparent, slightly viscous, aqueous liquid | ||
| LogP/Hphobicity | -0.714 | ||
| Isoelectric Point | 5.58 | ||
| Biotransformation | Not Available | ||
| Half Life | Not Available | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference | http://www.rxlist.com/cgi/generic3/collagenase.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | BIOD00010 | ||
| CAS Registry Number | 12/1/9001 | ||
| KEGG Compound ID | Not Available | ||
| PubChem ID | Not Available | ||
| PharmGKB ID | PA449107 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2063670 |
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