Codeine drug data and news

Codeine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name Codeine
Brand Names/Synonyms CCRIS 7555; Codeine; Codeine Anhydrous; Codeine Base [D.D]; Codeine [Anhydrous]; Codicept; Coducept; HSDB 3043; L-Codeine; Methylmorphine; Morphine Monomethyl Ether; Norcodeine, N-Methyl; Norcodine, N-Methyl
Indication For treatment and management of pain (Systemic), also used as an Antidiarrheal and as a cough suppressant.
Sponsored links
Description Not Available
Pharmacology Codeine, an opiate agonist in the CNS, is similar to other phenanthrene derivatives such as morphine. Codeine, in combination with guaifenesin or iodinated glycerol, is used as a cough suppressant and, as a single agent or in combination with acetaminophen or other products, is used for pain control and as an antidiarrheal agent.
Mechanism Of Action Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline is inhibited. Opioids also inhibit the release of vasopressin, somatostatin, insulin and glucagon. Codeine's analgesic activity is, most likely, due to its conversion to morphine. Opioids close N-type voltage-operated calcium channels (OP2-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist). This results in hyperpolarization and reduced neuronal excitability.
Codeine News
(When available)

Viagra plus cholesterol drug improves impotence  07 Mar 2006
Specifically, investigators have found that in men who are not initially helped by Viagra (sildenafil), treatment with Lipitor (atorvastatin) seems to improve ... - Reuters.uk,

Leave Viagra to the Customer  07 Mar 2006
Why do I need Viagra when my sex life is on a roll? ... Give me a break! People with sexual difficulties would come to you, if they need Viagra at all. ... - LiveArticles.org,

Viagra exceeds sales targets in 60 days  07 Mar 2006
HYDERABAD: Two months after its launch on December 26, 2005, Pfizer’s Viagra has exceeded its targets by capturing 1.8 percent of the market that is ... - Newindpress (subscription),

Arms are chopped down by champs  07 Mar 2006
DEFENDING champions Viagra Boys rose to the occasion in last Friday's top-of-the-table clash with Wheatsheaf Arms at the Hertfordshire Sports Village in ... - Herts 24,

Cialis - Invigorating men’s Sexual health  07 Mar 2006
Viagra and Cialis breaks the code of uncertainties. Access Viagra online to retrieve the flow being pumped back into your veins. ... - LiveArticles.org,

Protests continue as Thai leader remains defiant  07 Mar 2006
Specifically, investigators have found that in men who are not initially helped by Viagra (sildenafil), treatment with Lipitor (atorvastatin) seems to improve ... - Turkish Daily News (subscription),

Former Athletic Coach Sentenced In Sex Scandal  07 Mar 2006
...predators. Crowder made arrangements to meet the boys. When he arrived, police found condoms and opened packets of Viagra. Detectives ... - WTKR Your NewsChannel 3,

PETA’S ‘LIVE MAKE-OUT TOUR’ BEDS DOWN IN LAS VEGAS  07 Mar 2006
And vegetarian men don’t have to rely on chemical potions such as Viagra to be up for anything (the cholesterol in meat and other animal products causes ... - PETA (press release),

There's Nothing Worse Than Faking It  07 Mar 2006
...hard day of boozing, but you don't want to look disinterested in sex in case it could be held against you in future when you feel as randy as a rabbit on Viagra ... - Football365.com,

Viagra for overcoming sexual failure  Mar 3, 2006
...was a time when impotence in men was set to be the prime reason behind the shattering of many relationships until the ED treatment drug, Viagra was introduced. ... - LiveArticles.org,

Cialis- Viagra’s first Direct Competitor  Mar 3, 2006
Viagra is regarded as king medicine for ED while Cialis as prince. It is because Viagra is the first drug marketed for ED and Cialis ... - LiveArticles.org,

Enhanced Sexual Performance with Viagra  Mar 3, 2006
Medications like Viagra can make an easier way towards a happier sex life, but it is also important that couple know how to more fully use their bodies as ... - LiveArticles.org,

» Georgia legislature says pharmacists must fill all ...  Mar 3, 2006
...didn’t stir any vocal opposition, senators defeated an amendment that would have extended the provision to sexual performance enhancement drugs like Viagra. ... - Media girl,

Horses given Viagra to make them go faster  Feb 27, 2006
Two vets and a pharmacist were among 24 people arrested by police in Naples yesterday over claims that they fed Viagra to horses running in illegal races to ... - Guardian Unlimited,

Viagra breakthrough impotence drug  Mar 2, 2006
Viagra was more an expression of trust, a change much longed for and ultimately a pivotal point in overcoming serious shortfalls in the health of men. ... - LiveArticles.org,

Study: Viagra increases self-esteem  Feb 28, 2006
The study was conducted by Dr. Joseph C. Cappelleri, a scientist working for Pfizer Inc., the manufacturer of Viagra, and colleagues. ... - United Press International

Cialis a Tough Competitor to Viagra  Mar 2, 2006
...for Darwin. On ground are the unparalleled in industry, Cialis and Viagra. Tough? But choice should be for the best. Genuine Cialis ... - LiveArticles.org,

Martin County settles with teen forced to eat Viagra-laced ...  Mar 2, 2006
...a settlement agreement this morning between the Martin County Commission and a teenager who said he was forced to eat laxative- and Viagra-laced brownies while ... - Palm Beach Post,

No Viagra, none was needed. Good show  Mar 1, 2006
Given the robust economic circumstances and the healthy capital markets, what was needed was not a Viagra pill, but something that would not cause a headache. ... - Daily News & Analysis,

Man dies after taking viagra  Feb 28, 2006
Although police are still to establish the cause of the death, they suspect the man took some viagra capsules before being intimate with the woman at a lodge ... - Chronicle,

The Viagra Hardsell  Feb 27, 2006
When Pfizer launched Viagra seven years ago, the pharma giant knew it had a winner on its hands. ... Viagra in India is a different story. ... - Business Standard,

Viagra could treat Crohn's disease  Feb 24, 2006
The anti-impotence drug Viagra could help treat Crohn's disease researchers have found. ... However, Viagra helped to correct the low blood flow in patients. ... - Daily Mail - UK,

Viagra offers Crohn's hope  Feb 23, 2006
THE anti-impotence drug Viagra could help in the treatment of people with the inflammatory bowel disorder Crohn's disease, researchers said yesterday. ... - Scotsman,

Viagra could treat Crohn's disease  Feb 23, 2006
The anti-impotence drug Viagra could be of help in treating the inflammatory bowel disorder Crohn's disease, researchers have said. ... - Scotsman,

Cops say suspect tried to sell them Viagra  Feb 26, 2006
NEAR NORTH SIDE -- A Near West Side man tried to hawk illicit Viagra pills to two undercover Chicago narcotics officers at a CTA train station, officials say. ... - Chicago Tribune,

Viagra Hates Erectile Dysfunction  Feb 23, 2006
Viagra - the little blue pill is brought to the market to help millions of male persons with Erectile Dysfunction. The miracle drug ... - LiveArticles.org,

Levitra- Tough Competitor to Viagra  Feb 22, 2006
Viagra has long been the only drug in the market to fight impotency. Many companies around the world started their work on similar impotency drugs. ... - LiveArticles.org,

Caging your fears with Pfizer’s Viagra  Feb 23, 2006
The truth with which you could confess your abilities are never at stake with Pfizer’s Viagra. ... Buy Viagra and feel the heat of change sweeping past you. ... - LiveArticles.org,

Ignite Your Cold Romance With Viagra  Feb 20, 2006
Viagra is for people like you who in spite of intense passionate desires and sexual stimulation are not able to ‘rise to the occasion'. ... - LiveArticles.org,

Statins: Viagra's little helper?  Feb 22, 2006
PHILADELPHIA, Feb. 22 (UPI) -- The drug class statins may offer hope to men who haven't gotten improved erectile performance from drugs like Viagra. ... - United Press International

When Viagra Doesn't Work, Lipitor May Assist  Feb 21, 2006
PHILADELPHIA, June 21 - If Viagra (sildenafil) doesn't go the job, maybe all it needs is a kick start with Lipitor (atorvastatin), a small study here suggested ... - MedPage Today,

Viagra could cure Crohn's disease  Feb 27, 2006
...complaint. But now scientists believe they have found the cause of Crohn's disease, and they think it could be treated with Viagra. ... - News-Medical.net,

Bowel disease researchers find Viagra could be a remedy  Feb 24, 2006
...disease, an unpleasant and intractable bowel disorder that affects one in every thousand people in the UK - and they think it could be treated with Viagra. ... - EducationGuardian.co.uk,

Pfizer's Viagra could help Crohn's disease  Feb 27, 2006
...contrary to the commonly-held view that the disease is caused by excess inflammation, the findings suggest Crohn's sufferers could be helped by Pfizer's Viagra ... - Pharmaceutical Business Review

Viagra May Help Crohn's Disease  Feb 24, 2006
Researchers in the UK have a new theory to explain the cause of Crohn's disease, and they say medications like the erectile dysfunction drug Viagra may prove ... - WebMD

Viagra could be used to treat Crohn's patients, researchers say  Feb 24, 2006
Anthony Segal of University College London and his team believe the bowel disorder may be triggered by a weak immune system and Viagra may work to correct the ... - CBC Edmonton,

Viagra Offers Hope In Treatment Of Crohn’s Disease  Feb 23, 2006
Surprisingly, Viagra, given for the treatment of erectile dysfunction / impotence has been found to result in increased blood flow among Crohn's sufferers. ... - MedIndia,

Viagra May Possible Treatment for Crohn’s – Weak Immune System ...  Feb 24, 2006
Anthony Segal, from the University College London in the United Kingdom, believes “Viagra may be successful in correcting the low blood flow and may be ... - Best Syndication,

Health: Vaccines, Viagra, Ties, and Miscarriage  Feb 21, 2006
There is new hope for men who do not respond to Viagra as researchers at the University of Pennsylvania say the statin drug Lipitor, used to lower cholesterol ... - CBS 3,

Police arrest man for trying to sell Viagra  Feb 26, 2006
CHICAGO Police say a 41-year-old Chicago man has been arrested for allegedly trying to sell Viagra to two undercover Chicago narcotics officers. ... - WQAD,

Erectile Dysfunction: Can workout substitute Viagra?  Feb 27, 2006
...dysfunction. So, they easily jump into the bandwagon of people resorting to popping Viagra to prove that they are tiger in bed. ... - LiveArticles.org,

Yarchagumba, Nepal's Natural Viagra  Feb 22, 2006
And not only that, it is also believed to be a cure for sexual impotency - a Himalayan natural viagra. Its Latin name is cordyceps sinesis. ... - OhmyNews International,

China to handle Viagra patent lawsuit right  Feb 16, 2006
A government official said Wednesday that China will deal with a US drugmaker's lawsuit concerning Viagra's patent in compliance with the law. ... - China Daily,

GENERIC VIAGRA: VITAL KEY IN RELATIONSHIPS  Feb 16, 2006
...sex. Now that drugs like Viagra are easily available in the market, the threat of ED as relationship-buster has somewhat subsided. ... - LiveArticles.org,

Viagra plays saviour of the deprived sex  Feb 13, 2006
But Pfizer Pharmaceuticals introduced a revolutionary oral prescription drug named Viagra, FDA-approved in1998 for drug therapy treatment of erectile ... - LiveArticles.org,

Viagra an answer for Impotence  Feb 4, 2006
...how�. Viagra is the answer for the term impotence. Impotence ... dysfunction. Viagra has Sildenafil Citrate as an active ingredient. The ... - LiveArticles.org,

Dosage Forms oral solution, tablets
Drug_Category Narcotics; Antitussives; Analgesics; Opiate Agonists; ATC:N02AA08; ATC:R05DA04
Absorption well absorbed
Interactions Interactions for Codeine:

Codeine in combination with other narcotic analgesics, general anesthetics, phenothiazines, tranquilizers, sedative-hypnotics, or other CNS depressants (including alcohol) has additive depressant effects. When s.c. combination therapy is contemplated, the dosage of one or both agents should be reduced.

Toxicity Respiratory depression, sedation and miosis and common symptoms of overdose. Other symptoms include nausea, vomiting, skeletal muscle flaccidity, bradycardia, hypotension, and cool, clammy skin. Apnea and death may ensue
Organisms Affected Humans and other mammals
Chemical IUPAC Name (5(,6()-7,8-didehydro-4,5-epoxy-3-methoxy-17-methylmorphinan-6-ol
Chemical Formula C18H21NO3
Molecular Weight 299.364 g/mol
Smiles String CN1CCC23C4C1CC5=C2C(=C(C=C5)OC)OC3C(C=C4)O
Melting Point 154 - 156 °C
Water Solubility <0.1 g/100 mL
State solid
LogP/Hphobicity 1.809
Isoelectric Point 8.21
Biotransformation hepatic
Half Life 2-4 hours
Protein Binding [%] 7-25%
RxList Link RXlist
Sponsored links
Drug Reference http://www.drugs.com/cons/Codeine.html
http://www.rxlist.com/cgi/generic/codphos.htm
Drug Type Approved Drug
Accession No APRD00120
CAS Registry Number 76-57-3
KEGG Compound ID C06174
PubChem ID SID:149398
PharmGKB ID Not Available
SwissProt ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] 593451

Home | About | Cancers | Treatment | Medications
Copyright onconews.org 2005.
All Rights Reserved.
Google
 
Web onconews.org