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Cocaine
drug data and news
Cocaine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Cocaine | ||
| Brand Names/Synonyms | &Quot;C&Quot; Carrie; Badrock; Bazooka; Benzoylethylecgonine; Benzoylmethylecgonine; Bernice; Bernies; Beta-Cocain; Blast; Blizzard; Blow; Bouncing Powder; Bump; Burese; C" Carrie; COC; Cabello; Candy; Caviar; Cecil; Charlie; Chicken Scratch; Cholly; Coca; Cocain; Cocaina; Cocaine; Cocaine Free Base; Cocaine, L-; Cocaine-M; Cocktail; Coke; Cola; Corine; D-Pseudococaine; Dama Blanca; Delcaine; Depsococaine; Dextrocaine; Dust; Ecgonine, Methyl Ester, Benzoate; Eritroxilina; Erytroxylin; Flake; Flex; Florida Snow; Foo Foo; Freeze; G-Rock; Girl; Gold Dust; Goofball; Green Gold; HSDB 6469; Happy Dust; Happy Powder; Happy Trails; Heaven; Hell; Isocaine; Isococain; Isococaine; Jam; Kibbles N' Bits; Kokain; Kokan; Kokayeen; L-Cocain; L-Cocaine; Lady; Leaf; Line; Methyl Benzoylecgonine; Moonrocks; Neurocaine; None; Pimp's Drug; Prime Time; Rock; Sleighride; Snort; Star Dust; Star-Spangled Powder; Sugar; Sweet Stuff; Toke; Toot; Trails; White Girl or Lady; Yeyo; Zip | ||
| Indication | For the introduction of local (topical) anesthesia of accessible mucous membranes of the oral, laryngeal and nasal cavities | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Cocaine is a local anesthetic indicated for the introduction of local (topical) anesthesia of accessible mucous membranes of the oral, laryngeal and nasal cavities. | ||
| Mechanism Of Action | Cocaine produces anesthesia by inhibiting excitation of nerve endings or by blocking conduction in peripheral nerves. This is achieved by reversibly binding to and inactivating sodium channels. Sodium influx through these channels is necessary for the depolarization of nerve cell membranes and subsequent propagation of impulses along the course of the nerve. Cocaine is the only local anesthetic with vasoconstrictive properties. This is a result of its blockade of norepinephrine reuptake in the autonomic nervous system. Cocaine binds differentially to the dopamine, serotonin, and norepinephrine transport proteins and directly prevents the re-uptake of dopamine, serotonin, and norepinephrine into pre-synaptic neurons. Cocaine also produces a number of indirect actions, which alter other neuromodulatory systems (i.e., opioidergic, glutamatergic, and GABAergic systems). | ||
| Cocaine News (When available) |
Govt accused of failing to address cocaine problem 06 Mar 2006 Cocaine traces are found in toilets at the Oxford Union 06 Mar 2006 Cocaine nabbed in Slater arrest 06 Mar 2006 Waretown man charged with cocaine possession 06 Mar 2006 Cocaine, pot found during city arrest 06 Mar 2006 OBN Seizes 43 Kilos Of Cocaine 06 Mar 2006 Columbian President Is Furious With Bruce Willis' Cocaine Comments 06 Mar 2006 Police search turns up meth, cocaine 06 Mar 2006 Woman sentenced to prison for baby's death 06 Mar 2006 Judge nixes defendant's request to serve sentence on weekends 06 Mar 2006 Sadie Frost 06 Mar 2006 Police blotter 06 Mar 2006 Police Seize 23 Pounds Of Cocaine At Area Warehouse Mar 5, 2006 Man accused of cocaine trafficking Mar 5, 2006 Dookeran: Probe cocaine in water tank Mar 5, 2006 Three men arrested after cocaine and cannabis seizure Mar 4, 2006 12 Students Busted For Cocaine Mar 4, 2006 Teen accused of selling pot, cocaine Mar 4, 2006 In Our Towns Mar 5, 2006 Drug, alcohol dispositions Mar 5, 2006 $1M in cocaine never makes it to street Mar 3, 2006 Police hush up escape of 'cocaine queen' Mar 3, 2006 Counter-narcotics performance in Suriname improves Mar 5, 2006 Superior Court Mar 4, 2006 Cocaine Found On Middle School Campus Mar 3, 2006 State agents bust big cocaine ring in Butler County Mar 3, 2006 Headmaster: Student had cocaine Mar 3, 2006 DM airman caught in cocaine sting is given 20 months of ... Mar 2, 2006 Mother arrested after son took cocaine to daycare Mar 3, 2006 | ||
| Dosage Forms | LIQUID | ||
| Drug_Category | Vasoconstrictor Agents; Anesthetics; Local Anesthetics; ATC:N01BC01; ATC:R02AD03; ATC:S01HA01; ATC:S02DA02 | ||
| Absorption | Cocaine is absorbed from all sites of application, including mucous membranes and gastrointestinal mucosa. By oral or intra-nasal route, 60 to 80% of cocaine is absorbed. | ||
| Interactions |
Interactions for Cocaine: No information provided. | ||
| Toxicity | Intense agitation, convulsions, hypertension, rhythm disturbance, coronary insufficiency, hyperthermia, rhabdomyolysis, and renal impairment. Oral mouse LD50 = 96 mg/kg | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | methyl3-benzoyloxy-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylate | ||
| Chemical Formula | C17H21NO4 | ||
| Molecular Weight | 303.353 g/mol | ||
| Smiles String | CN1C2CCC1C(C(C2)OC(=O)C3=CC=CC=C3)C(=O)OC | ||
| Melting Point | 195 °C | ||
| Water Solubility | 1800 mg/L | ||
| State | Solid | ||
| LogP/Hphobicity | 2.393 | ||
| Isoelectric Point | 8.61 | ||
| Biotransformation | Hepatic. Cocaine is metabolized to benzoylecgonine and ecgonine methyl ester, which are both excreted in the urine. In the presence of alcohol, a further active metabolite, cocaethylene is formed, and is more toxic then cocaine itself. | ||
| Half Life | 1 hour | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Cocaine.html http://www.rxlist.com/cgi/generic/cocaine.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00080 | ||
| CAS Registry Number | 50-36-2 | ||
| KEGG Compound ID | C01416 | ||
| PubChem ID | SID:148543 | ||
| PharmGKB ID | PA449072 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2006308 |
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