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Coagulation factor VIIa
drug data and news
Coagulation factor VIIa drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Coagulation factor VIIa | ||
| Brand Names/Synonyms | Coagulation factor VII precursor;Serum prothrombin conversion accelerator;SPCA;Proconvertin;Eptacog alfa; NovoSeven (Novo Nordisk) | ||
| Indication | For treatment of hemorrhagic complications in hemophilia A and B | ||
| Sponsored links | Description | Recombinant human coagulation Factor VIIa (rFVIIa), intended for promoting hemostasis by activating the extrinsic pathway of the coagulation cascade.1 NovoSeven is a vitamin K-dependent glycoprotein consisting of 406 amino acid residues. Cloned and expressed in hamster kidney cells, the protein is catalytically active in a two-chain form. | |
| Pharmacology | Used in the treatment of bleeding episodes in hemophilia A or B. NovoSeven is recombinant Factor VIIa and, when complexed with tissue factor can activate coagulation Factor X to Factor Xa, as well as coagulation Factor IX to Factor IXa. Factor Xa, in complex with other factors, then converts prothrombin to thrombin, which leads to the formation of a hemostatic plug by converting fibrinogen to fibrin and thereby inducing local clotting. | ||
| Mechanism Of Action | NovoSeven activates the coagulation or clotting cascade by cleaving Factor IX and Factor X, which activates them and then leads to activation of thrombin and fibrin. | ||
| Coagulation factor VIIa News (When available) |
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| Dosage Forms | Not Available | ||
| Drug_Category | Coagulants; Thrombotic Agents | ||
| Absorption | Not Available | ||
| Interactions | Not Available | ||
| Toxicity | Not Available | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | Human coagulation factor VIIa | ||
| Chemical Formula | C1972H3076N560O597S28 | ||
| Molecular Weight | 45079.1 | ||
| Smiles String | Not Available | ||
| Melting Point | 58 oC (Petersen, L.C. et al., Eur. J. Biochem 261: 124-129 (1999)). | ||
| Water Solubility | Not Available | ||
| State | Transparent, slightly viscous, aqueous liquid | ||
| LogP/Hphobicity | -0.311 | ||
| Isoelectric Point | 6.09 | ||
| Biotransformation | Not Available | ||
| Half Life | Not Available | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Coagulation_factor_VIIa.html http://www.rxlist.com/cgi/generic3/novoseven.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | BIOD00006 | ||
| CAS Registry Number | 9001-25-6 | ||
| KEGG Compound ID | Not Available | ||
| PubChem ID | Not Available | ||
| PharmGKB ID | Not Available | ||
| SwissProt ID | FA7_HUMAN (P08709) | ||
| GenBank ID | M13232 | ||
| Drug ID Number [DIN] | Not Available |
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