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Clotrimazole
drug data and news
Clotrimazole drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Clotrimazole | ||
| Brand Names/Synonyms | BAY 5097; Bay B 5097; Bay B 9057; Bay-B 5097; Canesten; Canesten Cream; Canesten Solution; Canestine; Canifug; Chlotrimazole; Clotrimaderm; Clotrimaderm Cream; Clotrimazol; Clotrimazole; Clotrimazole Crystalline; Clotrimazole Znso4 Complex; Empecid; FB 5097; Femcare; Gyne Lotrimin; Gyne-Lotrimin; Gyne-Lotrimin 3; Gyne-Lotrimin 3 Combination Pack; Gyne-Lotrimin Combination Pack; Gynix; Gynixo; Lotion; Lotrimin; Lotrimin Af; Lotrimin Af Cream; Lotrimin Af Jock-Itch Cream; Lotrimin Af Lotion; Lotrimin Af Solution; Lotrimin Cream; Lotrimin Lotion; Lotrimin Solution; Lotrisone; Mono-Baycuten; Mycelax; Mycelex; Mycelex 7; Mycelex Cream; Mycelex G; Mycelex Otc; Mycelex Solution; Mycelex Troches; Mycelex Twin Pack; Mycelex-7; Mycelex-7 Combination Pack; Mycelex-G; Myclo Cream; Myclo Solution; Myclo Spray Solution; Myclo-Gyne; Mycosporin; Mykosporin; Myofug; Neo-Zol Cream; Pack; Pedisafe; Rimazole; Therapy; Travagizole; Trimysten; Trivagizole 3; Veltrim | ||
| Indication | For the local treatment of oropharyngeal candidiasis and vaginal yeast infections, also used in fungal infections of the skin. | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Clotrimazole, an imidazole antifungal agent, is used for the treatment of infections caused by various species of pathogenic dermatophytes, yeasts, and Malassezia furfur. These include ringworm, candidiasis, and tinea infections. Betamethasone and clotrimazole are used together to treat cutaneous tinea infections. | ||
| Mechanism Of Action | Clotrimazole interacts with 14-α demethylase, a cytochrome P-450 enzyme that converts lanosterol to ergosterol, an essential component of the yeast membrane. In this way, clotrimazole inhibits ergosterol synthesis, resulting in increased cellular permeability. Clotrimazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms and the uptake of purine, impair triglyceride and/or phospholipid biosynthesis, and inhibit the movement of calcium and potassium ions across the cell membrane by blocking the ion transport pathway known as the Gardos channel. | ||
| Clotrimazole News (When available) |
5 Killer Ways To Treat Athlete’s Foot Feb 20, 2006 Coffee in moderation relatively harmless Feb 6, 2006 Nigeria: NAFDAC shuts restaurant in Lagos Feb 1, 2006 Coffee in moderation relatively harmless Feb 6, 2006 NAFDAC shuts eatery in Lagos Jan 29, 2006 NAFDAC destroys N300m fake goods Jan 27, 2006 Athlete’s foot could require more treatment 11 Dec 2005 FIFTH DISEASE: A COMMON CHILDHOOD AILMENT DEAR DR. DONOHUE: Dec 5, 2005 Man found with 27 types of drugs Nov 29, 2005 Plan B predicament has FDA in hot water Sep 11, 2005 FC Council to Send & to Red Cross; Moran Assails Fed 'Criminal ... 08 Sep 2005 Intertrigo and Common Secondary Skin Infections Aug 30, 2005 TRICARE Adds 11 Meds to Its Uniform Formulary Aug 11, 2005 Fougera extends Line with Introduction of Clotrimazole & ... Jul 13, 2005 Lorus Therapeutics reports year end results for fiscal year 2005 Jul 21, 2005 NAFDAC Intercepts Fake Products Jun 27, 2005 Common skin conditions and treatments Jun 16, 2005 | ||
| Dosage Forms | creams, lotions, ointment, lozenges | ||
| Drug_Category | Antifungals; Anti-Infectives; ATC:A01AB18; ATC:D01AC01; ATC:G01AF02 | ||
| Absorption | Well absorbed orally but minimal if vaginal or topical | ||
| Interactions |
Interactions for Clotrimazole: No information provided. | ||
| Toxicity | Erythema, stinging, blistering, peeling, edema, pruritus, urticaria, burning, and general irritation of the skin, cramps | ||
| Organisms Affected | Yeast and other fungi | ||
| Chemical IUPAC Name | 1-[(2-chlorophenyl)-diphenyl-methyl]-1H-imidazole | ||
| Chemical Formula | C22H17ClN2 | ||
| Molecular Weight | 344.837 g/mol | ||
| Smiles String | C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CN=C4 | ||
| Melting Point | 147 - 149 °C | ||
| Water Solubility | 0.02984 mg/L | ||
| State | Solid | ||
| LogP/Hphobicity | 5.98 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | hepatic | ||
| Half Life | 2 hours | ||
| Protein Binding [%] | 90% | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Clotrimazole.html http://www.rxlist.com/cgi/generic2/clotrimaz.htm http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/gyn1191.shtml http://www.pharmgkb.org/views/index.jsp?objId= | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00244 | ||
| CAS Registry Number | 23593-75-1 | ||
| KEGG Compound ID | C06922 | ||
| PubChem ID | SID:174033 | ||
| PharmGKB ID | PA449057 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2229380 |
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