Clonidine drug data and news

Clonidine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name Clonidine
Brand Names/Synonyms Adesipress; CCRIS 7787; Catapres; Catapres-Tts; Catapresan; Catapressan; Catarpres; Catarpresan; Chlornidinum; Clonidin; Clonidine; Clonidine Hcl; Clonidinhydrochlorid; Clonidinum [Inn-Latin]; Clonistada; Dixarit; Duraclon; Duraclont; HSDB 3040; Iopidine; Ipotensium; Isoglaucon; M 5041T; M-5041T; ST 155BS; Tenso-Timelets
Indication For the treatment of hypertension and maybe used in prophylaxis of migraine or recurrent vascular headache; Menopausal flushing
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Description Not Available
Pharmacology Clonidine is an antihypertensive agent and an epidural agent for refractory cancer pain. Similar to guanabenz in mechanism of action, clonidine is used in the treatment of hypertension, opiate and nicotine withdrawal, vascular headaches, diabetic diarrhea, glaucoma, ulcerative colitis, Gilles de la Tourette's syndrome, menopause symptoms, severe pain in cancer patients refractory to opiate agonists, and neuropathic pain and in the diagnosis of pheochromocytoma.
Mechanism Of Action Clonidine acts as an agonist at presynaptic alpha(2)-receptors in the nucleus tractus solitarius of the medulla oblongata. Stimulation of these receptors results in the supression of efferent sympathetic pathways and the subsequent decrease in blood pressure and vascular tone in the heart, kidneys, and peripheral vasculature. Clonidine is also a partial agonist at presynaptic alpha(2)-adrenergic receptors of peripheral nerves in vascular smooth muscle.
Clonidine News
(When available)

Gran's syringe find horror  07 Mar 2006
By Sam Webb. GRANDMOTHER Rosemary Essex was horrified to find a syringe in a pile of rubbish next to her Coventry home. Mrs Essex ... - ic Coventry,

(PZ) Medical International Technology Announces Its Malaysian ...  07 Mar 2006
...invasive technique. The current method of inoculating poultry throughout most of the world is done via the needle/syringe method. This ... - Houston Chronicle,

Driving around Bayonne  07 Mar 2006
First, the girl in the passenger's seat told police she was sitting on a hypodermic syringe, had just finished shooting heroin, and had two bags of heroin in ... - The Jersey Journal,

Precision low flow pulseless fluid delivery  07 Mar 2006
...flows of 5ul/min. Previously, pulse-free metering, in the microlitre range, relied solely on syringe pump technology. The Smooth-flo ... - Laboratory Talk,

Wanted: NYC Crime Numbers  07 Mar 2006
...auditing purposes." Alas, the 21st Century NYPD won't be able to tell us how many folks got pinched with "synthetic opiates" versus "hypo syringe needles." But ... - Village Voice,

Woman charged with third DUI  07 Mar 2006
Brown said Wall had an insulin syringe believed to have cocaine in it. Wall was charged with possession of cocaine, a Schedule II narcotic. ... - Monroe County Advocate Democrat,

New HIV cases increase by 17% in 2005  07 Mar 2006
The needle and syringe exchange programmes has also been a factor in keeping infection rates in New Zealand below those of other countries. - Scoop.co.nz (press release),

Eight Health And Safety Travel Tips From The Doctors At MedToGo ...  07 Mar 2006
...home-based physician if you will be traveling with certain medications such as narcotics or those that require injections with a needle and syringe (eg, insulin ... - Emediawire (press release),

Glass syringe for dissolved gas analysis sampling  Mar 6, 2006
Popper and Sons has announced the introduction of its new 50ml glass syringe for Dissolved Gas Analysis (DGA) sampling. A precision ... - Laboratory Talk,

Trainer fined over syringe filled with snake venom  Mar 2, 2006
Grand National on Seagram, was fined £300 by the Jockey Club's disciplinary committee yesterday after he admitted being in possession of a syringe filled with ... - Guardian Unlimited,

Syringe attack leaves woman in critical condition  Feb 28, 2006
Pérez said she has been given several antibiotics in an attempt to counteract the dangerous bacteria or virus that she was given through a syringe and then ... - Daily Journal (subscription),

Thief Threatens To Use AIDS Syringe During Robbery  Mar 1, 2006
CHARLOTTE -- A thief threatened to stab a clerk with a syringe he says was filled with the AIDS virus at a Blockbuster store in Dilworth. ... - WSOCtv.com,

Man who used syringe to threaten couple sentenced to 4 1/2 years  Mar 1, 2006
BATHURST, NB (CP) - A man who used a syringe to threaten and rob a couple in northern New Brunswick has been sentenced to four years and six months in prison. ... - Canada East,

Mount Pearl readies fines over poor syringe disposal  Mar 2, 2006
The City of Mount Pearl has created a no-tolerance policy for people who improperly dispose of needles. Mayor Steve Kent says some ... - CBC - Newfoundland & Labrador,

Police reveal syringe haul  Feb 22, 2006
By Jacquelin Magnay in Sauze d'Oulx. IN A new raid, Italian police inspected the abruptly abandoned rented Olympic accommodation ... - Sydney Morning Herald,

Knife, syringe used in robberies  Feb 20, 2006
BANDITS armed with a knife and a syringe have held up two Melbourne businesses in separate robberies. A man brandishing a knife ... - Australian,

Syringe robberies trial put off  Feb 25, 2006
NORTHAMPTON - A jury trial scheduled to begin on Monday in the case of alleged "syringe robber" Jeffrey B. Vaughan has been put off indefinitely following a ... - The Republican,

Needlestick injuries beef up syringe market  Feb 15, 2006
...will exceed $2.49bn (€2.1bn) by 2009, buoyed on by the increase of incidences in needlestick injuries and high consumer demand for syringe alternatives. ... - In-PharmaTechnologist.com,

Syringe bandit held at bay with mop  Feb 8, 2006
...pm. He had walked into the Coffee Club and asked two female workers if he could use the toilet, before returning with a syringe. ... - NEWS.com.au,

Bikini bandit robs shop with syringe  Feb 4, 2006
A WOMAN clad in a rainbow-coloured bikini top apologised before robbing a Brisbane liquor store at syringe point. The woman demanded ... - NEWS.com.au,

CryoLife says US regulators OK BioGlue syringe tips  Feb 9, 2006
NEW YORK, Feb 9 (Reuters) - CryoLife, Inc. (CRY.N: Quote, Profile, Research) on Thursday said US regulators have approved two new syringe tips used to spread ... - Reuters

NMT abandons syringe business  Feb 10, 2006
LONDON (SHARECAST) - NMT Group has decided to turn its back on its syringe based medical devices division and will now transform itself into an investment ... - ShareCast,

Bikini Bandit Steals Booze At Syringe-Point  Feb 6, 2006
Wearing a rainbow-colored bikini top and a short denim skirt, the long, blond, ponytailed robber held a Brisbane Australian liquor store owner at syringe point ... - ShortNews.com,

SWNM Evaluating Syringe System Manufacturing Equipment for ...  Feb 14, 2006
...process of comparative analysis for purchasing its initial manufacturing equipment for production of its very promising, patented, safety syringe system, the ... - Market Wire (press release)

'Syringe' robber's brother balks  Feb 17, 2006
NORTHAMPTON - An Easthampton man who told police that his brother was the "syringe robber" said to a judge yesterday that he would rather face contempt-of ... - The Republican,

INVENTION OF AN OUCH-LESS SYRINGE NEW TO THE WORLD  Feb 17, 2006
Okano, 73, and Tetsuya Oyauchi, 38, together won the top award from the Japanese Medical Society for developing a super-thin “ouchless� syringe which has ... - Amherst Times.com,

Man threatens staff with syringe  Feb 9, 2006
09 February 2006 17:15 A corner shop owner has banned hooded tops after a man wearing one threatened female staff with a syringe supposedly full of acid. ... - Norfolk Eastern Daily Press,

No syringe found  Feb 8, 2006
The unfortunate needle-stick injury to a Kapunda youth last month is only the tip of a major world-wide problem. Authorities believe ... - Barossa Herald,

Drop-in center for women drug users in Nepali capital  Mar 5, 2006
Nepali Department for International Development, United Nations Development Program ( UNDP) and Richmond Fellowship will jointly run a syringe exchange program ... - People's Daily Online,

Stateline Area News in Brief  Mar 3, 2006
A student accidentally poked his finger on the syringe after a classmate found it during his walk to school. A boy found the syringe at the intersection of St. ... - Beloit Daily News,

At least 5 students poked with syringe  Feb 16, 2006
By 3TV. Some kindergartners at a Valley school were playing with a syringe they found at a bus stop. At least five children from ... - AZFamily (subscription),

Certified syringe filters improve HPLC results  Feb 3, 2006
Cronus certified syringe filters represent a new standard in Sample Preparation excellence and give users complete confidence in their results, says SMI-Labhut ... - Laboratory Talk,

Drop-in center for women drug users  Mar 4, 2006
The Department for International Development (DFID), United Nations Development Programme and Richmond Fellowship will jointly run a syringe exchange programme ... - Nepalnews.com,

I nearly stepped on needles  Mar 3, 2006
Her foot slipped into the shrubbery and she narrowly missed stepping on a discarded syringe. She said: 'I was almost poked by the needle. ... - Electric New Paper,

They shoot drugs in front of my little girl  Mar 3, 2006
One family living in the block claimed they took a syringe they found outside their flat to a nearby neighbourhood police post (NPP). ... - Electric New Paper,

Redefining HIV prevention for drug-using populations  Feb 27, 2006
...should include services like community outreach, HIV testing and counselling, prevention case management, drug abuse treatment, sterile syringe access, and ... - Express Outlook,

Baxa Automated Pharmacy Production Equipment on Show at the ...  Mar 3, 2006
During the meeting, demonstrations will be available for Baxa automated compounders, as well as the Rapid-Fillâ„¢ Automated Syringe Filler, which automates the ... - Emediawire (press release),

Counterfeiting arrests net possible stabbing weapon  Mar 5, 2006
...a home where Keeling and Esterholdt were staying, and found the knife, more fake bills and drug paraphernalia on the floor, including a syringe containing meth ... - The Casper Star Tribune,

Novel idea for valley tycoon  Mar 5, 2006
...gets frisky with a stunning nymphomaniac model, who offers him a Viagra pill and later tries to get him to inject his tender area with a syringe of muscle ... - San Jose Mercury News,

An easy pill to swallow: Digestible camera makes procedure a snap  Mar 5, 2006
He gingerly places the vitamin-size pill on his tongue and washes it down with a syringe of water, launching it on an incredible journey through his body. ... - Eagle Tribune,

Mononucleosis spot test  Mar 5, 2006
...fill with blood). A needle is inserted into the vein, and the blood is collected in an airtight vial or a syringe. During the procedure ... - drkoop.com

Caretek Medical announces Lead Drug Candidate for ImplaJect® ...  Feb 28, 2006
...migraine drug, a form of Sumatriptan that is known as Imigran in the UK and Imitrex in the USA and delivered via needle and syringe, was approximately $220 ... - Oxfordshire Bioscience Network (press release),

Hawke admits 'snake venom' offence  Mar 2, 2006
FORMER Grand National-winning rider Nigel Hawke was yesterday fined £300 by the Jockey Club after he was found with a syringe full of snake venom in the ... - Scotsman,

Dosage Forms tablets, patches
Drug_Category Sympatholytics; Antihypertensive Agents; Analgesics; Central Alpha-Agonists; ATC:C02AC01; ATC:N02CX02; ATC:S01EA03; ATC:S01EA04
Absorption 40-60%
Interactions -->Interactions for Clonidine:

Tablet

If a patient receiving clonidine hydrochloride is also taking tricyclic antidepressants, the effect of clonidine may be reduced, thus necessitating an increase in dosage. Clonidine hydrochloride may enhance the CNS-depressive effects of alcohol, barbiturates or other sedatives. Amitriptyline in combination with clonidine enhances the manifestation of corneal lesions in rats

Epidural Injection

Clonidine may potentiate the CNS-depressive effect of alcohol, barbiturates or other sedating drugs. Narcotic analgesics may potentiate the hypotensive effects of clonidine. Tricyclic antidepressants may antagonize the hypotensive effects of clonidine. The effects of tricyclic antidepressants on clonidine's analgesic actions are not known.

Beta blockers may exacerbate the hypertensive response seen with clonidine withdrawl. Also, due to the potential for additive effects such as bradycardia and AV block, caution is warranted in patients receiving clonidine with agents known to affect sinus node function or AV nodal conduction (e.g., digitalis, calcium channel blockers, and beta-blockers.)

There is one reported case of a patient with acute delirium associated with the simultaneous use of fluphenazine and oral clonidine. Symptoms resolved when clonidine was withdrawn and recurred when the patient was rechallenged with clonidine.

Epidural clonidine may prolong the duration of pharmacologic effects of epidural local anesthetics, including both sensory and motor blockade.

Toxicity Hypertension may develop early and may be followed by hypotension, bradycardia, respiratory depression, hypothermia, drowsiness, decreased or absent reflexes, weakness, irritability and miosis
Organisms Affected Humans and other mammals
Chemical IUPAC Name N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine
Chemical Formula C9H9Cl2N3
Molecular Weight 230.093 g/mol
Smiles String C1CN=C(N1)NC2=C(C=CC=C2Cl)Cl
Melting Point 130°C
Water Solubility 1g/13ml
State solid
LogP/Hphobicity 2.278
Isoelectric Point Not Available
Biotransformation hepatic
Half Life 12-16 hours
Protein Binding [%] 20-40%
RxList Link RXlist
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Drug Reference http://www.drugs.com/cons/Clonidine.html
http://www.rxlist.com/cgi/generic/clonidin.htm
Drug Type Approved Drug
Accession No APRD00174
CAS Registry Number 4205-90-7
KEGG Compound ID C06920
PubChem ID SID:163008
PharmGKB ID Not Available
SwissProt ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] 2247608

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