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Clonidine
drug data and news
Clonidine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Clonidine | ||
| Brand Names/Synonyms | Adesipress; CCRIS 7787; Catapres; Catapres-Tts; Catapresan; Catapressan; Catarpres; Catarpresan; Chlornidinum; Clonidin; Clonidine; Clonidine Hcl; Clonidinhydrochlorid; Clonidinum [Inn-Latin]; Clonistada; Dixarit; Duraclon; Duraclont; HSDB 3040; Iopidine; Ipotensium; Isoglaucon; M 5041T; M-5041T; ST 155BS; Tenso-Timelets | ||
| Indication | For the treatment of hypertension and maybe used in prophylaxis of migraine or recurrent vascular headache; Menopausal flushing | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Clonidine is an antihypertensive agent and an epidural agent for refractory cancer pain. Similar to guanabenz in mechanism of action, clonidine is used in the treatment of hypertension, opiate and nicotine withdrawal, vascular headaches, diabetic diarrhea, glaucoma, ulcerative colitis, Gilles de la Tourette's syndrome, menopause symptoms, severe pain in cancer patients refractory to opiate agonists, and neuropathic pain and in the diagnosis of pheochromocytoma. | ||
| Mechanism Of Action | Clonidine acts as an agonist at presynaptic alpha(2)-receptors in the nucleus tractus solitarius of the medulla oblongata. Stimulation of these receptors results in the supression of efferent sympathetic pathways and the subsequent decrease in blood pressure and vascular tone in the heart, kidneys, and peripheral vasculature. Clonidine is also a partial agonist at presynaptic alpha(2)-adrenergic receptors of peripheral nerves in vascular smooth muscle. | ||
| Clonidine News (When available) |
Gran's syringe find horror 07 Mar 2006 (PZ) Medical International Technology Announces Its Malaysian ... 07 Mar 2006 Driving around Bayonne 07 Mar 2006 Precision low flow pulseless fluid delivery 07 Mar 2006 Wanted: NYC Crime Numbers 07 Mar 2006 Woman charged with third DUI 07 Mar 2006 New HIV cases increase by 17% in 2005 07 Mar 2006 Eight Health And Safety Travel Tips From The Doctors At MedToGo ... 07 Mar 2006 Glass syringe for dissolved gas analysis sampling Mar 6, 2006 Trainer fined over syringe filled with snake venom Mar 2, 2006 Syringe attack leaves woman in critical condition Feb 28, 2006 Thief Threatens To Use AIDS Syringe During Robbery Mar 1, 2006 Man who used syringe to threaten couple sentenced to 4 1/2 years Mar 1, 2006 Mount Pearl readies fines over poor syringe disposal Mar 2, 2006 Police reveal syringe haul Feb 22, 2006 Knife, syringe used in robberies Feb 20, 2006 Syringe robberies trial put off Feb 25, 2006 Needlestick injuries beef up syringe market Feb 15, 2006 Syringe bandit held at bay with mop Feb 8, 2006 Bikini bandit robs shop with syringe Feb 4, 2006 CryoLife says US regulators OK BioGlue syringe tips Feb 9, 2006 NMT abandons syringe business Feb 10, 2006 Bikini Bandit Steals Booze At Syringe-Point Feb 6, 2006 SWNM Evaluating Syringe System Manufacturing Equipment for ... Feb 14, 2006 'Syringe' robber's brother balks Feb 17, 2006 INVENTION OF AN OUCH-LESS SYRINGE NEW TO THE WORLD Feb 17, 2006 Man threatens staff with syringe Feb 9, 2006 No syringe found Feb 8, 2006 Drop-in center for women drug users in Nepali capital Mar 5, 2006 Stateline Area News in Brief Mar 3, 2006 At least 5 students poked with syringe Feb 16, 2006 Certified syringe filters improve HPLC results Feb 3, 2006 Drop-in center for women drug users Mar 4, 2006 I nearly stepped on needles Mar 3, 2006 They shoot drugs in front of my little girl Mar 3, 2006 Redefining HIV prevention for drug-using populations Feb 27, 2006 Baxa Automated Pharmacy Production Equipment on Show at the ... Mar 3, 2006 Counterfeiting arrests net possible stabbing weapon Mar 5, 2006 Novel idea for valley tycoon Mar 5, 2006 An easy pill to swallow: Digestible camera makes procedure a snap Mar 5, 2006 Mononucleosis spot test Mar 5, 2006 Caretek Medical announces Lead Drug Candidate for ImplaJect® ... Feb 28, 2006 Hawke admits 'snake venom' offence Mar 2, 2006 | ||
| Dosage Forms | tablets, patches | ||
| Drug_Category | Sympatholytics; Antihypertensive Agents; Analgesics; Central Alpha-Agonists; ATC:C02AC01; ATC:N02CX02; ATC:S01EA03; ATC:S01EA04 | ||
| Absorption | 40-60% | ||
| Interactions |
-->Interactions for Clonidine: Tablet If a patient receiving clonidine hydrochloride is also taking tricyclic antidepressants, the effect of clonidine may be reduced, thus necessitating an increase in dosage. Clonidine hydrochloride may enhance the CNS-depressive effects of alcohol, barbiturates or other sedatives. Amitriptyline in combination with clonidine enhances the manifestation of corneal lesions in rats Epidural Injection Clonidine may potentiate the CNS-depressive effect of alcohol, barbiturates or other sedating drugs. Narcotic analgesics may potentiate the hypotensive effects of clonidine. Tricyclic antidepressants may antagonize the hypotensive effects of clonidine. The effects of tricyclic antidepressants on clonidine's analgesic actions are not known. Beta blockers may exacerbate the hypertensive response seen with clonidine withdrawl. Also, due to the potential for additive effects such as bradycardia and AV block, caution is warranted in patients receiving clonidine with agents known to affect sinus node function or AV nodal conduction (e.g., digitalis, calcium channel blockers, and beta-blockers.) There is one reported case of a patient with acute delirium associated with the simultaneous use of fluphenazine and oral clonidine. Symptoms resolved when clonidine was withdrawn and recurred when the patient was rechallenged with clonidine. Epidural clonidine may prolong the duration of pharmacologic effects of epidural local anesthetics, including both sensory and motor blockade. | ||
| Toxicity | Hypertension may develop early and may be followed by hypotension, bradycardia, respiratory depression, hypothermia, drowsiness, decreased or absent reflexes, weakness, irritability and miosis | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine | ||
| Chemical Formula | C9H9Cl2N3 | ||
| Molecular Weight | 230.093 g/mol | ||
| Smiles String | C1CN=C(N1)NC2=C(C=CC=C2Cl)Cl | ||
| Melting Point | 130°C | ||
| Water Solubility | 1g/13ml | ||
| State | solid | ||
| LogP/Hphobicity | 2.278 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | hepatic | ||
| Half Life | 12-16 hours | ||
| Protein Binding [%] | 20-40% | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Clonidine.html http://www.rxlist.com/cgi/generic/clonidin.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00174 | ||
| CAS Registry Number | 4205-90-7 | ||
| KEGG Compound ID | C06920 | ||
| PubChem ID | SID:163008 | ||
| PharmGKB ID | Not Available | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2247608 |
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