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Clonazepam
drug data and news
Clonazepam drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Clonazepam | ||
| Brand Names/Synonyms | Antelepsin; Antilepsin; Chlonazepam; Cloazepam; Clonazepam; Clonazepamum; Clonopin; Iktorivil; Klonopin; Klonopin Rapidly Disintegrating; Landsen; RO4023; Rivotril | ||
| Indication | Used as an anticonvulsant in the treatment of the Lennox-Gastaut syndrome (petit mal variant), akinetic and myoclonic seizures. | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Clonazepam, a benzodiazepine, is used primarily as an anticonvulsant in the treatment of absence seizures, petit mal variant seizures (Lennox-Gastaut syndrome), akinetic and myoclonic seizures, and nocturnal myoclonus. | ||
| Mechanism Of Action | Allosteric interactions between central benzodiazepine receptors and gamma-aminobutyric acid (GABA) receptors potentiate the effects of GABA. As GABA is an inhibitory neurotransmitter, this results in increased inhibition of the ascending reticular activating system. Benzodiazepines, in this way, block the cortical and limbic arousal that occurs following stimulation of the reticular pathways. | ||
| Clonazepam News (When available) |
Howard Scott's unfinished sonata 07 Mar 2006 Perugia Musica Classica - Leonidas Kavakos and Enrico Pace 07 Mar 2006 SOUTH KOREA: Factory gate exit count inflates car sales - paper 07 Mar 2006 Emerging Violinist Shin to Hold Concert 07 Mar 2006 French pianist set to perform all-Beethoven program at BU 07 Mar 2006 Misha Dichter & Friends: Westchester Philharmonic 07 Mar 2006 King Shares Look Unattractive Based On Generic Threats 07 Mar 2006 Outstanding performance from Watts at Tiedtke Concert Hall 07 Mar 2006 Boy ejected from car and killed in crash 07 Mar 2006 The real #1 source for AMD news, reviews, and info. Est 1998. 07 Mar 2006 The Auto Channel 07 Mar 2006 Quick Guide 07 Mar 2006 Festival takes note of rich American piano repertoire 07 Mar 2006 Violinist makes music sing for Whiting crowd 07 Mar 2006 Hyundai Sonata 2.4 Elite Mar 3, 2006 NARNIA To Support SONATA ARCTICA In Sweden - Mar. 3, 2006 Mar 3, 2006 Hyundai Sonata wins MotorWeek's 'Drivers' Choice Award' for Best ... Feb 21, 2006 2006 Hyundai Sonata GLS V6 Long-Term Test Update No. 12 Feb 21, 2006 SONATA ARCTICA Frontman Hospitalized; Hartford Show Cancelled ... Feb 22, 2006 Sonata's add-ons add up to value Feb 22, 2006 Beethoven sonata cycle concert Sunday Feb 22, 2006 '06 Sonata offers more space, comfort and power Feb 12, 2006 Could you walk away from a car crash? Mar 5, 2006 SONATA ARCTICA: 'Reckoning Night' Certified Gold In Finland - Feb. ... Feb 13, 2006 SONATA ARCTICA Certified Gold In Finland Feb 17, 2006 Hyundai Sonata named 'Best Family Sedan' Feb 10, 2006 '06 Hyundai Sonata top prize in Las Vegas Night Feb 16, 2006 Total redesign puts Sonata in spotlight Feb 3, 2006 Sonata fills boot with accolades Feb 16, 2006 Pianist captures sonata's rage, joy Feb 6, 2006 Auerbach sonata on Sunday program Feb 18, 2006 Musical 'Winter Sonata' moves audience Feb 7, 2006 Hyundai Sonata Named Best Family Sedan in US Feb 14, 2006 Piano Sonata in A Major Feb 14, 2006 Burbank sonata Feb 18, 2006 Violinist, pianist play in exceptional harmony Mar 6, 2006 Classical Review: Quartet shines in tug-of-war Mar 3, 2006 Big cars to drive used car market Mar 5, 2006 CRIME STOPPERS Police seek man who robbed couple Mar 5, 2006 Hyundai outsells previous February Mar 4, 2006 | ||
| Dosage Forms | Tablets - scored and unscored | ||
| Drug_Category | Anticonvulsants; Benzodiazepines; ATC:N03AE01 | ||
| Absorption | Clonazepam is rapidly and completely absorbed after oral administration. The absolute bioavailability of clonazepam is about 90%. | ||
| Interactions |
Interactions for Clonazepam: Effect of Clonazepam on the Pharmacokinetics of Other Drugs: Clonazepam does not appear to alter the pharmacokinetics of phenytoin, carbamazepine, or phenobarbital. The effect of clonazepam on the metabolism of other drugs has not been investigated. Effect of Other Drugs on the Pharmacokinetics of Clonazepam: Literature reports suggest that ranitidine, an agent that decreases stomach acidity, does not greatly alter clonazepam pharmacokinetics. In a study in which the 2 mg clonazepam orally disintegrating tablet was administered with and without propantheline (an anticholinergic agent with multiple effects on the GI tract) to healthy volunteers, the AUC of clonazepam was 10% lower and the Cmax of clonazepam was 20% lower when the orally disintegrating tablet was given with propantheline compared to when it was given alone. Fluoxetine does not affect the pharmacokinetics of clonazepam. Cytochrome P-450 inducers, such as phenytoin, carbamazepine and phenobarbital, induce clonazepam metabolism, causing an approximately 30% decrease in plasma clonazepam levels. Although clinical studies have not been performed, based on the involvement of the cytochrome P-450 3A family in clonazepam metabolism, inhibitors of this enzyme system, notably oral antifungal agents, should be used cautiously in patients receiving clonazepam. Pharmacodynamic Interactions: The CNS-depressant action of the benzodiazepine class of drugs may be potentiated by alcohol, narcotics, barbiturates, nonbarbiturate hypnotics, antianxiety agents, the phenothiazines, thioxanthene and butyrophenone classes of antipsychotic agents, monoamine oxidase inhibitors and the tricyclic antidepressants, and by other anticonvulsant drugs. | ||
| Toxicity | Somnolence, confusion, coma, and diminished reflexes | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 6-(2-chlorophenyl)-9-nitro-2,5-diazabicyclo[5.4.0]undeca-5,8,10,12-tetraen-3-one | ||
| Chemical Formula | C15H10ClN3O3 | ||
| Molecular Weight | 315.711 g/mol | ||
| Smiles String | C1C(=O)NC2=C(C=C(C=C2)[N+](=O)[O-])C(=N1)C3=CC=CC=C3Cl | ||
| Melting Point | 236.5 - 238.5 °C | ||
| Water Solubility | <0.1 mg/mL | ||
| State | solid | ||
| LogP/Hphobicity | 2.722 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Hepatic (Cytochrome P450, including CYP3A). Biotransformation occurs mainly by reduction of the 7-nitro group to the 4-amino derivative. This derivative can be acetylated, hydroxylated, and glucuronidated. | ||
| Half Life | 30-40 hours | ||
| Protein Binding [%] | 85% | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Clonazepam.html http://www.rxlist.com/cgi/generic/clonaz.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00054 | ||
| CAS Registry Number | 1622-61-3 | ||
| KEGG Compound ID | C06919 | ||
| PubChem ID | SID:158706 | ||
| PharmGKB ID | Not Available | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2242078 |
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