Clonazepam drug data and news

Clonazepam drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name Clonazepam
Brand Names/Synonyms Antelepsin; Antilepsin; Chlonazepam; Cloazepam; Clonazepam; Clonazepamum; Clonopin; Iktorivil; Klonopin; Klonopin Rapidly Disintegrating; Landsen; RO4023; Rivotril
Indication Used as an anticonvulsant in the treatment of the Lennox-Gastaut syndrome (petit mal variant), akinetic and myoclonic seizures.
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Description Not Available
Pharmacology Clonazepam, a benzodiazepine, is used primarily as an anticonvulsant in the treatment of absence seizures, petit mal variant seizures (Lennox-Gastaut syndrome), akinetic and myoclonic seizures, and nocturnal myoclonus.
Mechanism Of Action Allosteric interactions between central benzodiazepine receptors and gamma-aminobutyric acid (GABA) receptors potentiate the effects of GABA. As GABA is an inhibitory neurotransmitter, this results in increased inhibition of the ascending reticular activating system. Benzodiazepines, in this way, block the cortical and limbic arousal that occurs following stimulation of the reticular pathways.
Clonazepam News
(When available)

Howard Scott's unfinished sonata  07 Mar 2006
By Jack Thomas, Globe Correspondent | March 7, 2006. Howard Scott was turning 87, and on Saturday, at the assisted care facility ... - Boston Globe,

Perugia Musica Classica - Leonidas Kavakos and Enrico Pace  07 Mar 2006
Music: L. van Beethoven Sonata in A major op. 30 no. 1; F. Busoni Sonata no. 2 in E minor op. 36; J. Brahms Sonata in D minor op. 108. ... - Perugia Online,

SOUTH KOREA: Factory gate exit count inflates car sales - paper  07 Mar 2006
As for popular models such as the Sonata and Grandeur, sales as of 20 February accounted for more than 60% of the total monthly volume. ... - just-auto.com (subscription),

Emerging Violinist Shin to Hold Concert  07 Mar 2006
In a concert next week at Naru Arts Center, Shin will show off her technique and translation of such numbers as Violin Sonata in G Minor ``Il Trillo del Diavolo ... - Korea Times,

French pianist set to perform all-Beethoven program at BU  07 Mar 2006
His program consists of Sonata No. 2, Op. 31 “The Tempest,� Sonata No. 11, Op. 22, and Sonata No. 29, Op. 106 “Hammerklavier.�. ... - Brandon Sun,

Misha Dichter & Friends: Westchester Philharmonic  07 Mar 2006
Brahms, Ballade In D Major Opus 10, No. 1 & 2; Schubert, Sonata in A Minor; Op. ... Misha & Cipa Dichter, piano ? Mozart, Sonata for Two Pianos in D Major, K. 448. ... - AmericanTowns.com,

King Shares Look Unattractive Based On Generic Threats  07 Mar 2006
...research firm. Also facing generic threats are King's Skelaxin, a muscle relaxant, and Sonata, a treatment for insomnia. Each is ... - Forbes

Outstanding performance from Watts at Tiedtke Concert Hall  07 Mar 2006
The Tiedtke Hall has a nice resonance that made even the most modest change in dynamics audible anywhere in the room. Beethoven's Seventh Sonata, Op. 10, No. ... - Orlando Sentinel,

Boy ejected from car and killed in crash  07 Mar 2006
The collision between the Hyundai Sonata and Chevrolet Suburban sounded like a cannon blast to Kevin Gray, who lives at Gothic Avenue and Rinaldi Street. ... - Los Angeles Daily News,

The real #1 source for AMD news, reviews, and info. Est 1998.  07 Mar 2006
Antec did a wonderful job with their Sonata line of cases, Zalman with their heatsinks and as of late Asus have done an excellent job with their 0 decibel, fan ... - AMDZone,

The Auto Channel  07 Mar 2006
...rear impact tests. The models include three moderately priced cars -- Ford Fusion, Hyundai Sonata, and Pontiac G6. The other four ... - Autochannel

Quick Guide  07 Mar 2006
The moderately priced 2006 Hyundai Sonata showed the biggest improvement from past crash tests. The bonus for consumers: it comes with a standard side airbag. ... - CNN

Festival takes note of rich American piano repertoire  07 Mar 2006
...the first American classical superstar, and a rag by Scott Joplin, along with such seminal 20th-century masterworks as Ives' Concord Sonata and Copland's Piano ... - Baltimore Sun,

Violinist makes music sing for Whiting crowd  07 Mar 2006
From the beautifully phrased opening tones of Mozart's "Violin Sonata No. 2," Bell proved his stature as one of the leading violinists of our time. ... - Flint Journal,

Hyundai Sonata 2.4 Elite  Mar 3, 2006
With apparently perfect timing, enter the 2.4-litre Hyundai Sonata Elite. The four cylinder has the same body as the previously ... - AutSpeed,

NARNIA To Support SONATA ARCTICA In Sweden - Mar. 3, 2006  Mar 3, 2006
Swedish metallers NARNIA will support SONATA ARCTICA on the Swedish leg of their European tour. The dates are as follows: As previously ... - Blabbermouth.net,

Hyundai Sonata wins MotorWeek's 'Drivers' Choice Award' for Best ...  Feb 21, 2006
Juma Al Majid Est., the sole distributor for Hyundai vehicles in the UAE, announced that Hyundai Sonata was awarded as the Best Family Sedan 'Drivers' Choice ... - AME Info,

2006 Hyundai Sonata GLS V6 Long-Term Test Update No. 12  Feb 21, 2006
How does the Sonata do it? Once ... Award. Still, no midsize model comes close to winning over as many major global awards as the new Sonata. ... - Automobile.com

SONATA ARCTICA Frontman Hospitalized; Hartford Show Cancelled ...  Feb 22, 2006
Tony Kakko, lead singer for Finland's SONATA ARCTICA, was taken to a local hospital earlier today (Feb. 22) to have his irritated throat checked by a doctor. ... - Blabbermouth.net,

Sonata's add-ons add up to value  Feb 22, 2006
The automotive media has been saying very good things about the all-new 2006 Hyundai Sonata, and the automotive aftermarket also is catching on to a vehicle ... - DetNews.com,

Beethoven sonata cycle concert Sunday  Feb 22, 2006
4:50 pm, Feb. 22, 2006--UD's Department of Music will present faculty cellist Lawrence Stomberg with guest pianist Jonathan Faiman ... - UDaily,

'06 Sonata offers more space, comfort and power  Feb 12, 2006
The new, fully redesigned 2006 Sonata is the first Hyundai built in the United States, in Montgomery, Ala. Second, there's nothing ''less'' about the Sonata. ... - Miami Herald,

Could you walk away from a car crash?  Mar 5, 2006
Initially, the institute says it found a real problem when it sent the $22,000-dollar Hyundai Sonata down the runway. Lund: This is a failure of the seat. ... - Standard-Speaker,

SONATA ARCTICA: 'Reckoning Night' Certified Gold In Finland - Feb. ...  Feb 13, 2006
..."Reckoning Night", the latest album from the Finnish melodic metallers SONATA ARCTICA, has been certified gold in Finland for sales in excess of 15,000 copies. ... - Blabbermouth.net,

SONATA ARCTICA Certified Gold In Finland  Feb 17, 2006
...of the stage, audience sing-alongs, and meet-and-greets in front of the tour bus after their performances, Finnish melodic metallers SONATA ARCTICA's live ... - The Gauntlet,

Hyundai Sonata named 'Best Family Sedan'  Feb 10, 2006
Hyundai's Sonata captured the "Best Family Sedan" category in MotorWeek's 2006 Drivers' Choice Awards, becoming the first Korean-brand car to earn the ... - Montgomery Advertiser,

'06 Hyundai Sonata top prize in Las Vegas Night  Feb 16, 2006
The grand prize-a 2006 Hyundai Sonata GL-will be given away tomorrow night. Other raffle prizes will also be drawn every 30 minutes. ... - Saipan Tribune,

Total redesign puts Sonata in spotlight  Feb 3, 2006
But depreciation has been an issue when it comes to bigger saloons such as the Sonata. ... Looks aside the latest Sonata is a better bet than the old model. ... - TMCnet

Sonata fills boot with accolades  Feb 16, 2006
The accolades continue to flow for the ground breaking Hyundai Sonata, almost a year after its release here in New Zealand. The ... - Scoop.co.nz (press release),

Pianist captures sonata's rage, joy  Feb 6, 2006
...such a thing as a Super Bowl of piano sonatas — that is, the main event of the instrument's solo repertoire — it might be Beethoven's "Hammerklavier" Sonata ... - Pioneer Press,

Auerbach sonata on Sunday program  Feb 18, 2006
This weekend, lovers of new music have a chance to hear a cello sonata by the young Russian composer Lera Auerbach (I wrote about her winning the Hindemith ... - Palm Beach Post,

Musical 'Winter Sonata' moves audience  Feb 7, 2006
SAPPORO, Japan - Even without "Yonsama" or "Jiwoohime," "Winter Sonata," a Korean television drama with enormous popularity in Japan and across Asia, still has ... - Korea Herald (subscription),

Hyundai Sonata Named Best Family Sedan in US  Feb 14, 2006
Hyundai Motor¡¯s Sonata has been named best family sedan in a survey by US broadcaster PBS¡¯ ¡°MotorWeek.¡± The 2006 Drivers' Choice Awards sponsored ... - Chosun Ilbo,

Piano Sonata in A Major  Feb 14, 2006
Artist’s Showcase. Her name was on the program; she was to play Haydn’s famous Sonata in A Major (Hob.XXI:63). On the flyer ... - Am J Psychiatry (subscription)

Burbank sonata  Feb 18, 2006
THEY'RE LEGALIZING PIANO teachers in Burbank. Until now, public nuisances that they are, such teachers were forbidden to give lessons in their homes. ... - Los Angeles Times,

Violinist, pianist play in exceptional harmony  Mar 6, 2006
Less than two weeks after performing the program at Carnegie Hall as part of a national tour, Bell and Denk played Mozart's Sonata No. ... - Indianapolis Star,

Classical Review: Quartet shines in tug-of-war  Mar 3, 2006
The evening was built around Ludwig van Beethoven's 1803 Violin Sonata in A Major, Op. 47 — best known as the "Kreutzer" Sonata. ... 1 (Kreutzer Sonata) in 1923. ... - Toronto Star,

Big cars to drive used car market  Mar 5, 2006
Dealers say that bigger cars like Skoda Octavia, Hyundai Sonata and even Mercedes Benz offer better value for money in the used car market as their rates ... - CNN-IBN,

CRIME STOPPERS Police seek man who robbed couple  Mar 5, 2006
Beltway 8 North. He took an undetermined amount of cash and personal items, then fled in a blue Hyundai Sonata. He was described ... - Houston Chronicle,

Hyundai outsells previous February  Mar 4, 2006
The 2006 Sonata, made at the Montgomery Hyundai plant, posted some of the strongest sales gains for the automaker in February, up 41 percent over its 2005 ... - Montgomery Advertiser,

Dosage Forms Tablets - scored and unscored
Drug_Category Anticonvulsants; Benzodiazepines; ATC:N03AE01
Absorption Clonazepam is rapidly and completely absorbed after oral administration. The absolute bioavailability of clonazepam is about 90%.
Interactions Interactions for Clonazepam:

Effect of Clonazepam on the Pharmacokinetics of Other Drugs: Clonazepam does not appear to alter the pharmacokinetics of phenytoin, carbamazepine, or phenobarbital. The effect of clonazepam on the metabolism of other drugs has not been investigated.

Effect of Other Drugs on the Pharmacokinetics of Clonazepam: Literature reports suggest that ranitidine, an agent that decreases stomach acidity, does not greatly alter clonazepam pharmacokinetics.

In a study in which the 2 mg clonazepam orally disintegrating tablet was administered with and without propantheline (an anticholinergic agent with multiple effects on the GI tract) to healthy volunteers, the AUC of clonazepam was 10% lower and the Cmax of clonazepam was 20% lower when the orally disintegrating tablet was given with propantheline compared to when it was given alone.

Fluoxetine does not affect the pharmacokinetics of clonazepam. Cytochrome P-450 inducers, such as phenytoin, carbamazepine and phenobarbital, induce clonazepam metabolism, causing an approximately 30% decrease in plasma clonazepam levels. Although clinical studies have not been performed, based on the involvement of the cytochrome P-450 3A family in clonazepam metabolism, inhibitors of this enzyme system, notably oral antifungal agents, should be used cautiously in patients receiving clonazepam.

Pharmacodynamic Interactions: The CNS-depressant action of the benzodiazepine class of drugs may be potentiated by alcohol, narcotics, barbiturates, nonbarbiturate hypnotics, antianxiety agents, the phenothiazines, thioxanthene and butyrophenone classes of antipsychotic agents, monoamine oxidase inhibitors and the tricyclic antidepressants, and by other anticonvulsant drugs.

Toxicity Somnolence, confusion, coma, and diminished reflexes
Organisms Affected Humans and other mammals
Chemical IUPAC Name 6-(2-chlorophenyl)-9-nitro-2,5-diazabicyclo[5.4.0]undeca-5,8,10,12-tetraen-3-one
Chemical Formula C15H10ClN3O3
Molecular Weight 315.711 g/mol
Smiles String C1C(=O)NC2=C(C=C(C=C2)[N+](=O)[O-])C(=N1)C3=CC=CC=C3Cl
Melting Point 236.5 - 238.5 °C
Water Solubility <0.1 mg/mL
State solid
LogP/Hphobicity 2.722
Isoelectric Point Not Available
Biotransformation Hepatic (Cytochrome P450, including CYP3A). Biotransformation occurs mainly by reduction of the 7-nitro group to the 4-amino derivative. This derivative can be acetylated, hydroxylated, and glucuronidated.
Half Life 30-40 hours
Protein Binding [%] 85%
RxList Link RXlist
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Drug Reference http://www.drugs.com/cons/Clonazepam.html
http://www.rxlist.com/cgi/generic/clonaz.htm
Drug Type Approved Drug
Accession No APRD00054
CAS Registry Number 1622-61-3
KEGG Compound ID C06919
PubChem ID SID:158706
PharmGKB ID Not Available
SwissProt ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] 2242078

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