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Clomocycline
drug data and news
Clomocycline drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
Clomocycline
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| Brand Names/Synonyms |
Chlormethylenecycline; Clomociclina [Inn-Spanish]; Clomocycline; Clomocycline [Ban:Inn]; Clomocyclinum [Inn-Latin] |
| Indication |
For the treatment and management of Brucellosis;Mycoplasma infection;Acne vulgaris;Chlamydial infection;Chronic bronchitis |
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Description |
Not Available |
| Pharmacology |
Clomocycline is a tetracycline antibiotic that is commonly prescribed by medical doctors for infections and to treat acne. It may also be used to treat urinary tract infections, gum disease, and other bacterial infections such as gonorrhea and chlamydia. Clomocycline is also used commonly as a prophylactic treatment for infection by Bacillus anthracis (anthrax). It is also effective against Yersinia pestis and malaria and is also prescribed for the treatment of Lyme disease. Clomocycline inhibits cell growth by inhibiting translation. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. The binding is reversible in nature. Cells become resistant to Clomocycline by at least two mechanisms: efflux and ribosomal protection. In efflux, a resistance gene encodes a membrane protein that actively pumps Clomocycline out of the cell. This is the mechanism of action of the tetracycline resistance gene on the artificial plasmid pBR322. In ribosomal protection, a resistance gene encodes a protein which binds to the ribosome and prevents Clomocycline from acting on the ribosome. |
| Mechanism Of Action |
Clomocycline inhibits cell growth by inhibiting translation. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. The binding is reversible in nature. Clomocycline is lipophilic and can easily pass through the cell membrane or passively diffuses through porin channels in the bacterial membrane. |
Clomocycline News
(When available) |
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| Dosage Forms |
Not Available |
| Drug_Category |
Anti-bacterial Agents; ATC:J01AA11 |
| Absorption |
Not Available |
| Interactions |
Not Available |
| Toxicity |
Not Available |
| Organisms Affected |
Enteric bacteria and other eubacteria |
| Chemical IUPAC Name |
7-chloro-4-dimethylamino-6,10,11,12a-tetrahydroxy-2-[hydroxy-(hydroxymethylamino)methylidene]-6-methyl-4,4a,5,5a,6,12a-hexahydrotetracene-1,3,12-trione |
| Chemical Formula |
C23H25ClN2O9 |
| Molecular Weight |
508.905 g/mol |
| Smiles String |
CC1(C2CC3C(C(=O)C(=C(NCO)O)C(=O)C3(C(=O)C2=C(C4=C(C=CC(=C41)Cl)O)O)O)N(C)C)O[an error occurred while processing this directive] | |
