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Clodronate
drug data and news
Clodronate drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Clodronate | ||
| Brand Names/Synonyms | Acide Clodronique [Inn-French]; Acido Clodronico [Inn-Spanish]; Acidum Clodronicum [Inn-Latin]; Bonefos; Clodronate; Clodronic Acid; Clodronic Acid [Usan:Ban:Inn]; Dichloromethanediphosphonic Acid; Dichloromethylidene Diphosphonate; Methanedichlorodiphosphonate; Methanedichlorodiphosphonic Acid | ||
| Indication | For treatment of hypercalcemia of malignancy and osteolysis | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | A diphosphonate which affects calcium metabolism. It inhibits bone resorption and soft tissue calcification. | ||
| Mechanism Of Action | Not Available | ||
| Clodronate News (When available) |
Adjuvant Bondronat Therapy Plays Important Role in Prevention of ... Feb 20, 2006 Hypoxia-Induced Pulmonary Vascular Remodeling Requires Recruitment ... Feb 14, 2006 | ||
| Dosage Forms | SOLUTION | ||
| Drug_Category | Antihypocalcemic Agents; Osteoporosis Prophylactic; Antineoplastic Agents; ATC:M05BA02 | ||
| Absorption | Not Available | ||
| Interactions | Not Available | ||
| Toxicity | Not Available | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | (dichloro-phosphono-methyl)phosphonic acid | ||
| Chemical Formula | CH4Cl2O6P2 | ||
| Molecular Weight | 244.892 g/mol | ||
| Smiles String | C(P(=O)(O)O)(P(=O)(O)O)(Cl)Cl | ||
| Melting Point | Not Available | ||
| Water Solubility | Not Available | ||
| State | Solid | ||
| LogP/Hphobicity | Not Available | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Clodronate is not metabolized in human | ||
| Half Life | ~13 hours | ||
| Protein Binding [%] | 2%-36% | ||
| RxList Link | Not Available>RXlist | ||
| Sponsored links | |||
| Drug Reference | http://www.drugs.com/cons/Clodronate.html | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00639 | ||
| CAS Registry Number | 22560-50-5 | ||
| KEGG Compound ID | Not Available | ||
| PubChem ID | SID:168153 | ||
| PharmGKB ID | PA10239 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | Not Available |
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