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Clobazam
drug data and news
Clobazam drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Clobazam | ||
| Brand Names/Synonyms | Chlorepin; Clobazam; Clorepin; Frisium; H 4723; H-4723; HR 376; LM 2717; LM-2717; Mystan; RU-4723; Urbadan; Urbanyl | ||
| Indication | For treatment and management of epilepsy and anxiety disorder. | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Clobazam is a barbiturate used in combination with acetaminophen or aspirin and caffeine for its sedative and relaxant effects in the treatment of tension headaches, migraines, and pain. | ||
| Mechanism Of Action | Clobazam binds at a distinct binding site associated with a Cl- ionopore at the GABA-A receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is prolonged as a result. | ||
| Clobazam News (When available) |
PR Newswire (press release), ...of Behavioral and Psychiatric Events in Children (Poster #303) * Use of Levetiracetam in Juvenile Myoclonic Epilepsy (Poster #333) * Clobazam for the Treatment ... Spider-Man won't attempt another climb Dec 4, 2005 Daily Nation (subscription), 22. He says the pills were Urbanyl, a drug prescribed by his doctors to ward off epileptic seizures commonly known as Clobazam. ... | ||
| Dosage Forms | TABLET | ||
| Drug_Category | Anticonvulsants; Benzodiazepines; ATC:N05BA09 | ||
| Absorption | Bioavailability is 90%. | ||
| Interactions |
Interactions for Clobazam: Alcohol (increases bioavailability by 50%), cimetidine, and valproates. | ||
| Toxicity | Not Available | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 9-chloro-2-methyl-6-phenyl-2,6-diazabicyclo[5.4.0]undeca-8,10,12-triene-3,5-dione | ||
| Chemical Formula | C16H13ClN2O2 | ||
| Molecular Weight | 300.739 g/mol | ||
| Smiles String | CN1C(=O)CC(=O)N(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3 | ||
| Melting Point | Not Available | ||
| Water Solubility | 188 mg/L | ||
| State | Solid | ||
| LogP/Hphobicity | 2.62 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Hepatic. Clobazam has two major metabolites: N-desmethyl-clobazam and 4'-hydroxyclobazam, the former of which is active. The demethylation is facilitated by CYP2C19, CYP3A4, and CYP2B6 and the 4'-hydroxyclobazam by CYP2C18 and CYP2C19. | ||
| Half Life | 18 hours | ||
| Protein Binding [%] | 83% | ||
| RxList Link | Not Available>RXlist | ||
| Sponsored links | |||
| Drug Reference | http://www.drugs.com/cons/Clobazam.html | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00307 | ||
| CAS Registry Number | 22316-47-8 | ||
| KEGG Compound ID | D01253 | ||
| PubChem ID | SID:583072 | ||
| PharmGKB ID | PA10888 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2247230 |
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