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Clindamycin
drug data and news
Clindamycin drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Clindamycin | ||
| Brand Names/Synonyms | Chlolincocin; Cleocin; Cleocin Hcl; Cleocin Pediatric; Cleocin Phosphate; Cleocin T; Cleocin T Gel; Cleocin T Lotion; Cleocin T Topical Solution; Clinda-Derm; Clindagel; Clindamicina [Inn-Spanish]; Clindamycin; Clindamycin Hcl; Clindamycin Hydrochloride; Clindamycin Phosphate; Clindamycin [Usan:Ban:Inn]; Clindamycine [French]; Clindamycine [Inn-French]; Clindamycinum [Inn-Latin]; Clindesse; Clindets; Clinimycin; DRG-0011; Dalacin; Dalacin C; Dalacin C Flavored Granules; Dalacin C Phosphate; Dalacin T Topical Solution; Evoclin; HSDB 3037; Sobelin | ||
| Indication | For the treatment of serious infections caused by susceptible anaerobic bacteria (anaerobes, streptococci, pneumococci, and staphylococci) | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Clindamycin is an antibiotic, similar to and a derivative of lincomycin. Clindamycin can be used in topical or systemic treatment. It is effective as an anti-anaerobic antibiotic and antiprotozoal. | ||
| Mechanism Of Action | Systemic/Vaginal-Clindamycin inhibits protein synthesis of bacteria by binding to the 50 S ribosomal subunits of the bacteria. Topical-Clindamycin reduces free fatty acid concentrations on the skin and to suppress the growth of Propionibacterium acnes (Corynebacterium acnes) , an anaerobe found in sebaceous glands and follicles. | ||
| Clindamycin News (When available) |
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| Dosage Forms | capsules; Intramuscular solution; Intravenousparenteral solution; Topical Solution; Topical Lotion; Topical Gel; Vaginal Cream; Vaginal Ovules | ||
| Drug_Category | Anti-bacterial Agents; Lincomycins; ATC:D10AF01; ATC:G01AA10; ATC:J01FF01 | ||
| Absorption | - 90% - oral | ||
| Interactions |
Interactions for Clindamycin: Clindamycin has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents. Therefore, it should be used with caution in patients receiving such agents. Antagonism has been demonstrated between clindamycin and erythromycin in vitro. Because of possible clinical significance, these two drugs should not be administered concurrently. | ||
| Toxicity | Orally and parenterally administered clindamycin has been associated with severe colitis (pseudomembranous colitis) which may result in patient death. Use of the topical formulation of clindamycin results in absorption of the antibiotic from the skin surface. Diarrhea, bloody diarrhea, and colitis (including pseudomembranous colitis) have been reported with the use of topical and systemic clindamycin. | ||
| Organisms Affected | Enteric bacteria and other eubacteria | ||
| Chemical IUPAC Name | N-[2-chloro-1-(3,4,5-trihydroxy-6-methylsulfanyl-tetrahydropyran-2-yl)-propyl]-1-methyl-4-propyl-pyrrolidine-2-carboxamide | ||
| Chemical Formula | C18H33ClN2O5S | ||
| Molecular Weight | 424.984 g/mol | ||
| Smiles String | CCCC1CC(N(C1)C)C(=O)NC(C2C(C |