Clidinium drug data and news

Clidinium drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name

Clidinium

Brand Names/Synonyms

Clidinium; Quarzan

Indication

For the treatment of peptic ulcer disease and also to help relieve abdominal or stomach spasms or cramps due to colicky abdominal pain, diverticulitis, and irritable bowel syndrome.

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Description

Not Available

Pharmacology

Clidinium is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract.

Mechanism Of Action

Inhibits muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites.

Clidinium News
(When available)

Rescued from War-torn Europe: Dr. Leo H. Sternbach and His Notable ... Sep 29, 2005
Valium, Librium, Quarzan(R) (clidinium bromide), Mogadon(R) (nitrazepam) and Klonopin(R) (clonazepam) are examples of products that have emerged from his ... - PR Newswire (press release),

Rescued from War-torn Europe: Dr. Leo H. Sternbach and His Notable ... Sep 29, 2005
Valium, Librium, Quarzan® (clidinium bromide), Mogadon® (nitrazepam) and Klonopin® (clonazepam) are examples of products that have emerged from his ... - Yahoo! News (press release)

Victim of 2002 shooting arrested Aug 27, 2005
Street in Lee, admitted to not having a prescription for those pills, which were listed in court papers as Clonazepam, chlordiazepoxide clidinium bromide and ... - Berkshire Eagle,

Valium Inventor Inducted into National Inventors Hall of Fame May 10, 2005
Valium, Librium, Quarzan® (clidinium bromide), Mogadon® (nitrazepam) and Klonopin® (clonazepam) are examples of products that have emerged from his ... - PharmaLive.com,

Dosage Forms

CAPSULES (2.5, 5 mg)

Drug_Category

Antiarrhythmic Agents; Anticholinergic Agents; Antispasmodics; Parasympatholytics; ATC:A03AB

Absorption

Not Available

Interactions

Interactions for Clidinium:
Amantadine, tricyclic antidepressants, and MAOIs may increase anticholinergic effect of clidinium. Clidinium may decrease the effect of phenothiazines, levodopa, and ketoconazole.

Toxicity

Signs of toxicity include confusion, paralytic ileus, urinary hesitancy/retention, and blurred vision.

Organisms Affected

Humans and other mammals

Chemical IUPAC Name

(4-methyl-4-azoniabicyclo[2.2.2]oct-2-yl)2-hydroxy-2,2-diphenyl-ethanoate

Chemical Formula

C22H26NO3

Molecular Weight

352.447 g/mol

Smiles String

C[N+]12CCC(CC1)C(C2)OC(=O)C(C3=CC=CC=C3)(C4=CC=CC=C4)O

Melting Point

240-241 °C

Water Solubility

Not Available

State

Solid

LogP/Hphobicity

Not Available

Isoelectric Point

Not Available

Biotransformation

Not Available

Half Life

Not Available

Protein Binding [%]

Not Available

RxList Link

Not Available>RXlist

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Drug Reference

http://www.drugs.com/cons/Clidinium.html

Drug Type

Approved Drug

Accession No

APRD00737

CAS Registry Number

7020-55-5

KEGG Compound ID

C07853

PubChem ID

SID:10055

PharmGKB ID

PA449033

SwissProt ID

Not Available

GenBank ID

Not Available

Drug ID Number [DIN]

Not Available