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Cisplatin
drug data and news
Cisplatin drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Cisplatin | ||
| Brand Names/Synonyms | Abiplatin; Biocisplatinum; Briplatin; CACP; CPDC; CPDD; Carboquone; Cis Pt Ii; Cis-Ddp; Cis-Diaminedichloroplatinum; Cis-Diamminedichloroplatinum; Cismaplat; Cisplatin; Cisplatine; Cisplatyl; Citoplationo; DDP; Ddpt; Diamminedichloroplatinum; Dichlorodiammineplatinumiiyelloworangextl; Lederplatin; Neoplatin; P4394; Plastin; Platamine; Platiblastin; Platidiam; Platinex; Platinol; Platinol-Aq; Platinoxan; Platinum Ammine Chloride; Platinum Ammonium Chloride; Platinum Diamine Dichloride; Randa; Trans-Ddp; Trans-Diaminedichloroplatinum; Trans-Diamminedichloroplatinum; Trans-Dichlorodiammine Platinum; Trans-Platinumdiammine Dichloride | ||
| Indication | For the management of metastatic testicular tumors, metastatic ovarian tumors and advanced bladder cancer. | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Cisplatin is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Alkylating agents are cell cycle-nonspecific. Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death. | ||
| Mechanism Of Action | Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their attempts to replace the alkylated bases, preventing DNA synthesis and RNA transcription from the affected DNA, 2) DNA damage via the formation of cross-links (bonds between atoms in the DNA) which prevents DNA from being separated for synthesis or transcription, and 3) the induction of mispairing of the nucleotides leading to mutations. | ||
| Cisplatin News (When available) |
Rossum Civil Trial Set To Begin 06 Mar 2006 Drug-patch safety triggers an FDA probe Mar 5, 2006 Four Aiken County residents die from overdose of fentanyl Feb 24, 2006 Four Die from Fentanyl Overdose Feb 23, 2006 The Effects of Tramadol and Fentanyl on Gastrointestinal Motility ... Feb 21, 2006 Four in Aiken County overdose on potent painkiller fentanyl Feb 24, 2006 Risk of Overdose Deaths Linked to Fentanyl Pain Patch Under ... Feb 15, 2006 Overdose Deaths Linked to Fentanyl Pain Patch Being Investigated ... Feb 1, 2006 BioDelivery Sciences Receives Non-Approvable Notification from FDA ... Mar 1, 2006 Man charged in drug death Feb 27, 2006 S&P 500 February Winners & Losers Mar 1, 2006 Painkiller overdose links four deaths Feb 24, 2006 BioDelivery Sciences Receives Initial $2 Million Payment from CDC Feb 16, 2006 BioDelivery Sciences Receives Initial $2 Million Payment from CDC ... Feb 16, 2006 Pain Patch Abuse: A Deadly High Feb 7, 2006 Acrux's Igor Gonda and Nina Wilkins Join Experts on Pain and ... Feb 8, 2006 Four Aiken County residents die of drug overdose Feb 23, 2006 Two face charges they stole narcotics Feb 22, 2006 Woman charged in overdose death Feb 7, 2006 Confiscated heroin contained deadly mixture PORTER COUNTY: Arrests ... Feb 10, 2006 Pharmacist's death ruled accidental Feb 25, 2006 Police: Deadly pain-killer being sold as heroin Feb 7, 2006 Endo Pharmaceuticals Reports Fourth Quarter and Full-Year 2005 ... Feb 15, 2006 Ishpeming Woman Arrested In Overdose Death Feb 7, 2006 BioDelivery Sciences Retains Addison Whitney as Brand Development ... Feb 2, 2006 Cancer drug suspected in heroin deaths Feb 8, 2006 Morrisville pharma receives first $2M from deal Feb 16, 2006 Ishpeming woman faces drug charges connected to a man's death Feb 8, 2006 Woman arraigned on drug charge Feb 8, 2006 Internet found to help drugs trafficking Mar 2, 2006 Greene County drug sweep nets 11 supsects Feb 22, 2006 VIVUS Announces Grant of Key Patent for MDTS(R) Delivery System Mar 1, 2006 Recordati: 2005 Accounts Approved by the Board. Dividend ... Mar 2, 2006 When Parents Look The Other Way Mar 1, 2006 New treatments subsidised for acne, pain Feb 27, 2006 Prescription drug overdose finds mother starting foundation Mar 1, 2006 BioDelivery Sciences Receives $2 Million Milestone Payment Feb 16, 2006 Overdose Death Suspect Back In Court Feb 16, 2006 Police Searching For CVS Robber Feb 6, 2006 Drug may be stronger than heroin, police say Feb 7, 2006 Potentially Fatal Narcotic Being Sold As Heroin Feb 6, 2006 'Bad’ batch of heroin reaches NWI Feb 11, 2006 St. Clair Township man gets prison time in drug death Feb 8, 2006 Police finish investigation of fatal truck fire Feb 9, 2006 Man found dead could be victim of fake heroin Feb 9, 2006 | ||
| Dosage Forms | SOLUTION | ||
| Drug_Category | Radiation-Sensitizing Agents; Antineoplastic Agents; ATC:L01XA01 | ||
| Absorption | Not Available | ||
| Interactions |
-->Interactions for Cisplatin: Plasma levels of anticonvulsant agents may become subtherapeutic during cisplatin therapy. In a randomized trial in advanced ovarian cancer, response duration was adversely affected when pyridoxine was used in combination with altretamine (hexamethylmelamine) and cisplatin.1 | ||
| Toxicity | Not Available | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | dichloroplatinum;azanide | ||
| Chemical Formula | Cl2H4N2Pt | ||
| Molecular Weight | 298.029 g/mol | ||
| Smiles String | [NH2-].[NH2-].Cl[Pt+2]Cl | ||
| Melting Point | 270 °C | ||
| Water Solubility | 2530 mg/L | ||
| State | Solid | ||
| LogP/Hphobicity | -2.19 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Not Available | ||
| Half Life | 20-30 minutes | ||
| Protein Binding [%] | > 90% | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Cisplatin.html http://www.rxlist.com/cgi/generic3/cisplatin.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00359 | ||
| CAS Registry Number | 15663-27-1 | ||
| KEGG Compound ID | C06911 | ||
| PubChem ID | SID:170030 | ||
| PharmGKB ID | PA449014 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2126613 |
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