Cisplatin drug data and news

Cisplatin drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name Cisplatin
Brand Names/Synonyms Abiplatin; Biocisplatinum; Briplatin; CACP; CPDC; CPDD; Carboquone; Cis Pt Ii; Cis-Ddp; Cis-Diaminedichloroplatinum; Cis-Diamminedichloroplatinum; Cismaplat; Cisplatin; Cisplatine; Cisplatyl; Citoplationo; DDP; Ddpt; Diamminedichloroplatinum; Dichlorodiammineplatinumiiyelloworangextl; Lederplatin; Neoplatin; P4394; Plastin; Platamine; Platiblastin; Platidiam; Platinex; Platinol; Platinol-Aq; Platinoxan; Platinum Ammine Chloride; Platinum Ammonium Chloride; Platinum Diamine Dichloride; Randa; Trans-Ddp; Trans-Diaminedichloroplatinum; Trans-Diamminedichloroplatinum; Trans-Dichlorodiammine Platinum; Trans-Platinumdiammine Dichloride
Indication For the management of metastatic testicular tumors, metastatic ovarian tumors and advanced bladder cancer.
Sponsored links
Description Not Available
Pharmacology Cisplatin is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Alkylating agents are cell cycle-nonspecific. Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death.
Mechanism Of Action Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their attempts to replace the alkylated bases, preventing DNA synthesis and RNA transcription from the affected DNA, 2) DNA damage via the formation of cross-links (bonds between atoms in the DNA) which prevents DNA from being separated for synthesis or transcription, and 3) the induction of mispairing of the nucleotides leading to mutations.
Cisplatin News
(When available)

Rossum Civil Trial Set To Begin  06 Mar 2006
Greg Devillers. She murdered him with an overdose of fentanyl, which was stolen from her lab at the Medical Examiner's office. Rose ... - NBC Sandiego.com,

Drug-patch safety triggers an FDA probe  Mar 5, 2006
By Dawn Fallik. In July, the Food and Drug Administration announced an investigation into 120 deaths caused by fentanyl patches, used for chronic pain. ... - Philadelphia Inquirer,

Four Aiken County residents die from overdose of fentanyl  Feb 24, 2006
...(Aiken-AP) February 23, 2006 - Four Aiken County residents have died recently from an overdose of the painkiller fentanyl. The deaths ... - WIS,

Four Die from Fentanyl Overdose  Feb 23, 2006
AIKEN, SC (AP) - Four Aiken County residents have died recently from an overdose of the painkiller fentanyl. The deaths are sparking ... - WLTX.com,

The Effects of Tramadol and Fentanyl on Gastrointestinal Motility ...  Feb 21, 2006
In this study, we investigated the effects of tramadol and fentanyl on gastrointestinal transit (GIT) during acute systemic inflammation in an experimental ... - Anesthesia & Analgesia (subscription),

Four in Aiken County overdose on potent painkiller fentanyl  Feb 24, 2006
AIKEN -- Four Aiken County residents have died recently from overdoses of the painkiller fentanyl, sparking concerns about the powerful drug's misuse and abuse ... - Spartanburg Herald Journal (subscription),

Risk of Overdose Deaths Linked to Fentanyl Pain Patch Under ...  Feb 15, 2006
...(openPR) - February 15, 2006 - Jersey City, NJ - Consumers are warned of defective fentanyl pain patches. Known as the Duragesic ... - Open PR (press release),

Overdose Deaths Linked to Fentanyl Pain Patch Being Investigated ...  Feb 1, 2006
New Jersey February 2006 - The New Jersey, USA Offices of Bagolie Friedman Injury Lawyers are investigating overdose deaths linked to the fentanyl pain patch. ... - Open PR (press release),

BioDelivery Sciences Receives Non-Approvable Notification from FDA ...  Mar 1, 2006
In the meantime, we will maintain focus on our flagship BEMA(TM) Fentanyl product, which is now progressing through Phase III, and on the other products and ... - Genetic Engineering News,

Man charged in drug death  Feb 27, 2006
Public Act 167 of 2005 makes it a homicide to deliver a Schedule 1 or 2 controlled substance other than marijuana, in this case Fentanyl, to another person ... - Ann Arbor News,

S&P 500 February Winners & Losers  Mar 1, 2006
The company appears to have a successful product with its Fentanyl transdermal system--a chronic-pain patch equivalent to Alza's Duragesic. ... - Forbes

Painkiller overdose links four deaths  Feb 24, 2006
...back on Shawn Noe recently, it was the fourth time in just a few months that someone in Aiken County had died from overdosing on the popular painkiller fentanyl ... - Augusta Chronicle (subscription),

BioDelivery Sciences Receives Initial $2 Million Payment from CDC  Feb 16, 2006
This resulted from BDSI achieving certain key milestones in the clinical development of its BEMA(TM) Fentanyl formulation. As established ... - Carolina Newswire (press release),

BioDelivery Sciences Receives Initial $2 Million Payment from CDC ...  Feb 16, 2006
This resulted from BioDelivery achieving certain key milestones in the clinical development of its BEMA Fentanyl formulation. As ... - dBusinessNews Triangle (press release),

Pain Patch Abuse: A Deadly High  Feb 7, 2006
Fentanyl patches, or duragesics, are supposed to be put on your arm. ... She uses the fentanyl patches on people who have cancer or are terminally-ill. ... - WVNS-TV,

Acrux's Igor Gonda and Nina Wilkins Join Experts on Pain and ...  Feb 8, 2006
Gonda's presentation will focus on his company's work with fentanyl, a potent and widely used medication to treat chronic pain caused by cancer, arthritis and ... - Genetic Engineering News,

Four Aiken County residents die of drug overdose  Feb 23, 2006
AIKEN, SC (AP) - Four Aiken County residents have died recently from overdoses of the painkiller fentanyl, sparking concerns about the powerful drug's misuse ... - Hilton Head Island Packet,

Two face charges they stole narcotics  Feb 22, 2006
The state attorney general’s office alleges Clough took doses of Duragesic, the brand name for a fentanyl transdermal patch, from two elderly women at the ... - Portsmouth Herald News,

Woman charged in overdose death  Feb 7, 2006
ISHPEMING - A 34-year-old Ishpeming woman was scheduled to be arraigned today on one count of delivery of Fentanyl. The woman, whose ... - Marquette Mining Journal,

Confiscated heroin contained deadly mixture PORTER COUNTY: Arrests ...  Feb 10, 2006
The heroin confiscated during the investigation against the Portage men was tested and found to be heroin mixed with Fentanyl, a pain-killer 80 times more ... - nwitimes.com,

Pharmacist's death ruled accidental  Feb 25, 2006
The death of a 34-year-old Streator pharmacist who overdosed on the powerful pain killer fentanyl was ruled accidental by a coroner's jury Thursday. ... - MyWebTimes.com,

Police: Deadly pain-killer being sold as heroin  Feb 7, 2006
On Monday, Chicago Police officials alerted the public, saying they believe a synthetic drug called fentanyl has been sold as heroin. ... - Chicago Sun-Times,

Endo Pharmaceuticals Reports Fourth Quarter and Full-Year 2005 ...  Feb 15, 2006
7,669 751 Add: Upfront and milestone payments to partners 750 3,000 Less: Reversal of the remaining reserve related to the transdermal fentanyl patch inventory ... - PR Newswire (press release),

Ishpeming Woman Arrested In Overdose Death  Feb 7, 2006
Police believe she provided Fentanyl to 30-year old Adam Johnson before he died in August of last year. Police say Fentanyl is an ... - WLUC-TV,

BioDelivery Sciences Retains Addison Whitney as Brand Development ...  Feb 2, 2006
...to develop the brand identity and brand strategy for its BEMA(TM) drug delivery technology and BEMA(TM) Fentanyl, the company's lead BEMA(TM) formulation. ... - Genetic Engineering News,

Cancer drug suspected in heroin deaths  Feb 8, 2006
The cancer drug suspected in the deaths is Fentanyl, which is 80 times more potent than morphine and up to hundreds of times stronger than the heroin with ... - Munster Times,

Morrisville pharma receives first $2M from deal  Feb 16, 2006
...trials. With trials for BEMA Fentanyl on track, BDSI on Thursday said it has received the first $2 million of the funding from CDC. ... - Raleigh Triangle Business Journal,

Ishpeming woman faces drug charges connected to a man's death  Feb 8, 2006
August 27th. He had overdosed on Fentanyl. Fentanyl is a powerful narcotic pain killer typically prescribed for serious pain. A ... - WOOD-TV,

Woman arraigned on drug charge  Feb 8, 2006
...home, Willey said. It was later determined that Adam Johnson, who was dating Sherri LaFountain Johnson, died of an overdose of Fentanyl, Willey said. ... - Marquette Mining Journal,

Internet found to help drugs trafficking  Mar 2, 2006
...which are known to be increasingly abused and are sought after at illicit markets are hydrocodone and oxycodone, methadone, fentanyl, amphetamine and ... - Computer Business Review,

Greene County drug sweep nets 11 supsects  Feb 22, 2006
Teri Ball, 23, of Carmichaels was charged with possession of fentanyl, possession with intent to deliver fentanyl and conspiracy. ... - Uniontown Herald Standard,

VIVUS Announces Grant of Key Patent for MDTS(R) Delivery System  Mar 1, 2006
Acrux has licensed USA rights for Evamist and Testosterone MDTS to VIVUS and AUS/NZ distribution rights for Testosterone MDTS and Fentanyl MDTS to CSL Limited. ... - International News Service,

Recordati: 2005 Accounts Approved by the Board. Dividend ...  Mar 2, 2006
...was signed with Lavipharm Laboratories (USA) for the marketing and sale of a new transdermal patch containing the narcotic analgesic fentanyl, indicated for ... - PharmaLive.com (press release),

When Parents Look The Other Way  Mar 1, 2006
Then one day, two years ago, he got a call from the police saying his son's name was mentioned by another teen who had overdosed on a fentanyl patch. ... - WGRZ-TV,

New treatments subsidised for acne, pain  Feb 27, 2006
Capsaicin cream is the latest pain relief treatment added to the Pharmaceutical Schedule in moves which have also seen oxycodone and fentanyl patches added for ... - Scoop.co.nz (press release),

Prescription drug overdose finds mother starting foundation  Mar 1, 2006
...home. The medical examiner said he died of a prescription narcotic overdose of Fentanyl just two weeks shy of his 23rd birthday. ... - Boca Raton News,

BioDelivery Sciences Receives $2 Million Milestone Payment  Feb 16, 2006
The company will receive up to $7 million as it proceeds with Phase III clinical trials of its patented means of delivering the narcotic Fentanyl with an oral ... - Local Tech Wire,

Overdose Death Suspect Back In Court  Feb 16, 2006
...delivering a controlled substance. Ishpeming Police allege that she provide the Fentanyl that killed 30-year old Adam Johnson. She had a ... - WLUC-TV,

Police Searching For CVS Robber  Feb 6, 2006
...waistband. The man demanded a variety of drugs including oxycondine, Percocet, methadone, and Fentanyl patches and then fled the store. ... - Boston Channel.com,

Drug may be stronger than heroin, police say  Feb 7, 2006
...illegal drug users Monday that a dangerous batch of narcotics being sold as heroin on the South Side may be a much stronger synthetic drug called fentanyl. ... - Chicago Tribune,

Potentially Fatal Narcotic Being Sold As Heroin  Feb 6, 2006
The narcotic, known as fentanyl, is 80 times stronger than morphine and can be hundreds of times more powerful than heroin. Fentanyl ... - CBS2 Chicago,

'Bad’ batch of heroin reaches NWI  Feb 11, 2006
...on the drugs are tentative, Robert Taylor said, but indicate the drugs being sold by Jeffery Copeland, 19, of Portage, contained fentanyl, a prescription pain ... - Gary Post Tribune,

St. Clair Township man gets prison time in drug death  Feb 8, 2006
Police said Govett on Oct. 16, 2004, distributed the painkiller fentanyl at a house party in the 1000 block of Chestnut Street in Port Huron. ... - Port Huron Times Herald,

Police finish investigation of fatal truck fire  Feb 9, 2006
The tests found the drug fentanyl in high amounts inside Schrack's system, Stukenholtz said. Fentanyl is often prescribed in a patch to deal with chronic pain. ... - La Vista Sun,

Man found dead could be victim of fake heroin  Feb 9, 2006
Police said they suspect the victims thought they were buying heroin, but it was a synthetic narcotic known as fentanyl, which is sometimes used as a pain ... - Chicago Sun-Times,

Dosage Forms SOLUTION
Drug_Category Radiation-Sensitizing Agents; Antineoplastic Agents; ATC:L01XA01
Absorption Not Available
Interactions -->Interactions for Cisplatin:

Plasma levels of anticonvulsant agents may become subtherapeutic during cisplatin therapy.

In a randomized trial in advanced ovarian cancer, response duration was adversely affected when pyridoxine was used in combination with altretamine (hexamethylmelamine) and cisplatin.1

Toxicity Not Available
Organisms Affected Humans and other mammals
Chemical IUPAC Name dichloroplatinum;azanide
Chemical Formula Cl2H4N2Pt
Molecular Weight 298.029 g/mol
Smiles String [NH2-].[NH2-].Cl[Pt+2]Cl
Melting Point 270 °C
Water Solubility 2530 mg/L
State Solid
LogP/Hphobicity -2.19
Isoelectric Point Not Available
Biotransformation Not Available
Half Life 20-30 minutes
Protein Binding [%] > 90%
RxList Link RXlist
Sponsored links
Drug Reference http://www.drugs.com/cons/Cisplatin.html
http://www.rxlist.com/cgi/generic3/cisplatin.htm
Drug Type Approved Drug
Accession No APRD00359
CAS Registry Number 15663-27-1
KEGG Compound ID C06911
PubChem ID SID:170030
PharmGKB ID PA449014
SwissProt ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] 2126613

Home | About | Cancers | Treatment | Medications
Copyright onconews.org 2005.
All Rights Reserved.
Google
 
Web onconews.org