Ciprofloxacin drug data and news

Ciprofloxacin drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name Ciprofloxacin
Brand Names/Synonyms Bacquinor; Baycip; Bernoflox; CIPROFLOXACIN HCL; Ciflox; Cifloxin; Ciloxan; Ciprinol; Cipro; Cipro I.V.; Cipro Xl; Cipro Xr; Ciprobay; Ciprocinol; Ciprodar; Ciprofloxacin; Ciprofloxacin Base; Ciprofloxacin Dihydrochloride; Ciprofloxacin Hydrochloride; Ciprofloxacin Monohydrochloride; Ciprofloxacina; Cipromycin; Ciproquinol; Ciproxan; Ciproxin; Flociprin; Floxin; Floxin Otic; Floxin in Dextrose 5%; Ocuflox; Ofloxacin; Proquin Xr; Septicide; Velomonit
Indication For the treatment of Bacterial infection of Respiratory tract, UTI, Uncomplicated Cystitis in females, GI, Chronic Bacterial Prostatitis, CNS, Immuno compromised patients, Skin, Bone and Joint Infections, Uncomplicated cervical and urethral gonorrhea
Sponsored links
Description Not Available
Pharmacology Ciprofloxacin, a broad-spectrum antiinfective agent of the fluoroquinolone class, is used to treat gram-negative infections, sexually transmitted diseases, mycobacterial infections, corneal ulcers, and bacterial conjunctivitis.
Mechanism Of Action Ciprofloxacin has in vitro activity against a wide range of gram-negative and gram-positive organisms. Ciprofloxacin inhibits bacterial DNA gyrase, an enzyme responsible for counteracting excessive supercoiling of DNA during replication or transcription. The mechanism of action of quinolones, including ciprofloxacin, is different from that of other antimicrobial agents such as beta-lactams, macrolides, tetracyclines, or aminoglycosides; therefore, organisms resistant to these drugs may be susceptible to ciprofloxacin. There is no known cross-resistance between ciprofloxacin and other classes of antimicrobials.
Ciprofloxacin News
(When available)

Testosterone And Manhood  07 Mar 2006
When I was asked to write about testosterone and manhood, I started to think of the different ages and the influence of testosterone. ... - DailyIndia.com,

Team SA on a high after Oscar win  07 Mar 2006
Febbraio was found to have an elevated level of testosterone after a test. She sent a letter from her gynaecologist stating that ... - Independent Online,

Sex Chromosome Genes Influence Aggression Andmaternal Behavior ...  07 Mar 2006
It’s simple to blame male hormones, like testosterone, for male behavior such as aggression. But maybe it’s in our genes, too. ... - Science Daily (press release)

Oscient Pharmaceuticals Reports Financial Results for Fourth ...  07 Mar 2006
...also recorded more than $1.4 million in revenue from the Company's co-promotion agreement with Auxilium Pharmaceuticals for TESTIM(R) 1% testosterone gel. ... - Genetic Engineering News,

Sports Nutrition  07 Mar 2006
...extract twice daily for a 12-week period favorably altered body composition while concurrently increasing bone mass and serum free testosterone levels in ... - Natural Products Industry Insider,

Hunting's one of safest sports, far safer than basketball, Rev. ...  07 Mar 2006
Greeley claims hunting is some sort of release for raging male testosterone, although his contention flies in the face of the most recent statistics, which ... - Arizona Daily Star,

Moms make lousy dads  07 Mar 2006
...makes sense that a boy needs a man in his life to act as a role model, to show him not only how to curb his temper and to temper his testosterone, but also how ... - Town Hall,

Not Wanting to Be Left Out, Men Find Their Own 'Pause'  07 Mar 2006
Please do not write letters explaining that there are serious consequences to low levels of testosterone in older men that can require medication. I know that. ... - New York Times,

New shows take wing — but will they fly?  07 Mar 2006
Potentially saving this show from testosterone overload, Ryan and Mamet place an emphasis on the soldiers' wives, who live next door to each other on a ... - Houston Chronicle,

A woman's guide to success in the Kremlin  07 Mar 2006
...that may change now that the only female candidate in the last presidential election has written a guide on how to get ahead in the testosterone-fuelled world ... - Guardian Unlimited,

Iran: More Jaw and Less War  07 Mar 2006
Sounds eminently sensible, doesn’t it? But in these peculiar times, sensibility, not to mention testosterone, usually triumphs over sense. ... - Arab News,

Germans bid to purge themselves from their doping past  07 Mar 2006
...result from its books despite concrete proof that specific swimmers were fed a diet of Oral Turinabol, an anabolic steroid, and testosterone-related products ... - Times Online,

Can you choose your baby's sex?  07 Mar 2006
...of Auckland, shows that dominant and confident women are more likely to have boys because the fertilised egg is exposed to higher female testosterone levels. ... - Independent,

Hawksley Workman (Darren Calabrese/cns)  07 Mar 2006
Now, Canada’s quirkiest cabaret dropout, Hawksley Workman, has traded in his testosterone-infused tunes for something more delicate, introspective and lonely ... - Dose.ca,

Women in Sport promotion set to push limits  07 Mar 2006
...and drinks as well, making it an excellent way for prospective players to have a look at the sport in a more social and less testosterone-loaded environment. ... - Cayman Net News,

What's on tonight? Monday  07 Mar 2006
...things, try to outgolf the other pros. You can practically smell the testosterone coming through the screen. I'm sure it's a heck ... - Albuquerque Tribune,

Gospel of impotence  07 Mar 2006
...flexibility of neo-pagan permissiveness. Archbishop Akinola and others like him have spiritual testosterone. Many African bishops and ... - Pittsburgh Tribune-Review,

Hair Today - Gone Tomorrow?  07 Mar 2006
Some women develop a particular pattern of hair loss because of genetics, age and the male hormone testosterone. However, hair loss also can occur because of: - eMaxHealth.com,

A Sensual Tango of the Dances  07 Mar 2006
...of the tangos. In its entirety, this performance was testosterone-driven, yielding several all-male dance pieces. The male dominance ... - New University,

VW's nasty new spokesdemon.  07 Mar 2006
...mistreat his girlfriend. I have news: That's not his "Fast" he's making friends with. It's his "testosterone.". Let me say upfront ... - Slate

On the road: I Keano, Up on Roof, The Long and the Short and the ...  07 Mar 2006
In defence of the two other shows making up the testosterone-heavy trio, though, I have to say that Richard Bean's new play in Hull, Up on Roof, and Willis ... - Telegraph.co.uk,

Testosterone Deprivation Doesn't Stop Prostate Cancer: Study  Feb 27, 2006
A treatment that deprives men with localized prostate cancer of testosterone in hopes that the cancer's spread will be significantly slowed doesn't appear to ... - WWAY NewsChannel 3,

Lifestyle, Health Related to a Good Sex Life as Men Age, Says the ...  Mar 6, 2006
Although testosterone levels fall just as many men begin to experience sexual dysfunction, the Harvard Men's Health Watch reports that most men have plenty of ... - Yahoo! News (press release)

School remains testosterone-free zone  Feb 24, 2006
...by whitney ross. MATTHEWS — In Matthews Elementary School, girls rule. Not only is it one of the smallest schools in the county ... - Marion Chronicle Tribune,

Health Canada Issues Warning on Methyl-1-Testosterone  Feb 23, 2006
February 23, 2006) – Health Canada recently issued an advisory to warn consumers not to use supplements containing methyl-1-testosterone, including the ... - SFCPressPoint (press release),

The Sub-Fertile Stallion  Mar 6, 2006
...are the testes. Within their confines spermatozoa are produced along with testosterone the primary male sex hormone. The testes ... - TheHorse.com,

Theology and testosterone  Feb 5, 2006
And they again highlight the volatility of mixing testosterone and theology; an even more toxic mixture of the same has been seen on the streets of Beirut and ... - Times Online,

Hollywood testosterone king Michael Bay has been charged with ...  Feb 14, 2006
Bay's production company, Platinum Dunes, will attempt to crank out the 11th installment in the hearty horror series for New Line Cinema by October--on Friday ... - E! Online

CROI: Disappointment for glitazones, metformin and testosterone ...  Feb 10, 2006
A third study from the United States, ACTG 5079, examined the effects of a 1% testosterone gel rubbed onto the skin and providing 10g of testosterone daily in ... - Aidsmap,

Testosterone influences sexual behaviour  Feb 9, 2006
Ince, a sex educator and leader of the Sex Party, said that when he offers courses to women, he tells them that testosterone levels cause many men to have a ... - Georgia Straight,

Phil Parker: Testosterone is on parade today  Feb 15, 2006
...land the quad! Thankfully, the Winter Olympics get a heavy shot of testosterone today. Find something else to watch, Mom. A dude ... - Albuquerque Tribune,

Testosterone Replacement in Older Men and Atherosclerosis ...  Feb 13, 2006
As men grow older, their testosterone levels decrease with age. One-third of men, 70 years of age or older, have low testosterone levels. ... - Community Dispatch (press release)

Encouraging results for Zonagen testosterone drug  Feb 6, 2006
...company Zonagen has released positive top-line results of an open-label study of Androxal, the company's candidate for the treatment of testosterone deficiency ... - Pharmaceutical Business Review

Society must find more testosterone  Feb 5, 2006
Not only are men expected to act like sissies in public, but many men are so confused they actually think they have to check their testosterone at the door as ... - Eastern Echo,

Testosterone proves a fertile area for Ardana  Feb 1, 2006
ARDANA, the Edinburgh-based biotech company, said it remained on track to launch its testosterone cream into the multi-million pound market for male ... - Scotsman,

Watson wins approval for generic testosterone product  Feb 1, 2006
...based specialty drug maker Watson Pharmaceuticals has received final approval from the FDA for its generic version of a testosterone therapy produced by Solvay ... - Pharmaceutical Business Review

Following in Darwin’s footprints: Hau unlocks secrets of ...  Feb 27, 2006
...only 17 minutes is sufficient to trigger a cascade of hormones that head straight to the gonads causing them to grow and produce testosterone — flipping the ... - Princeton University,

COMPLETE BREAKDOWN OF WWE WELLNESS PROGRAM  Feb 27, 2006
Androgenic Steroids (AAS): The non-medical use of anabolic androgenic steroids, which include and are based on the natural steroid Testosterone, is prohibited. ... - Pro Wrestling Insider,

VIVUS Announces Grant of Key Patent for MDTS(R) Delivery System  Mar 1, 2006
...provides protection for the MDTS applicator, which is currently used in two of VIVUS's women's health products under clinical development: Testosterone MDTS(R ... - International News Service,

Dosage Forms LIQUID; OINTMENT; SOLUTION; SUSPENSION; TABLET; TABLET (COMBINED RELEASE); TABLET (EXTENDED-RELEASE)
Drug_Category Anti-Infectives; Quinolones; ATC:J01MA02; ATC:S01AX13; ATC:S03AA07
Absorption 70-80%
Interactions -->Interactions for Ciprofloxacin:

Caffeine

Some quinolones, including ciprofloxacin, have also been shown to interfere with the metabolism of caffeine. This may lead to reduced clearance of caffeine and a prolongation of its serum half-life.

Cyclosporine

Some quinolones, including ciprofloxacin, have been associated with transient elevations in serum creatinine in patients receiving cyclosporine concomitantly.

Glyburide

The concomitant administration of ciprofloxacin with the sulfonylurea glyburide has, on rare occasions, resulted in severe hypoglycemia.

Histamine H2-receptor antagonists

Histamine H2-receptor antagonists appear to have no significant effect on the bioavailability of ciprofloxacin.

Methotrexate

Renal tubular transport of methotrexate may be inhibited by concomitant administration of ciprofloxacin, potentially leading to increased plasma levels of methotrexate. This might increase the risk of methotrexate toxic reactions. Therefore, patients under methotrexate therapy should be carefully monitored when concomitant ciprofloxacin therapy is indicated.

Multivalent Cation-Containing Products

Concurrent administration of a quinolone, including ciprofloxacin, with multivalent cation-containing products such as magnesium or aluminum antacids, sucralfate, VIDEX chewable/buffered tablets or pediatric powder, or products containing calcium, iron, or zinc may substantially decrease the absorption of ciprofloxacin, resulting in serum and urine levels considerably lower than desired. Proquin XR should be administered at least 4 hours before or 2 hours after these products. This time window is different than for other oral formulations of ciprofloxacin, which are usually administered 2 hours before or 6 hours after antacids.

Non-steroidal anti-inflammatory drugs (but not aspirin)

These drugs in combination with very high doses of quinolones have been shown to provoke convulsions in pre-clinical studies.

Omeprazole

The rate and extent of absorption of ciprofloxacin was bioequivalent when Proquin XR was given alone or when Proquin XR was given 2 hours after omeprazole at the dose that maximally suppresses gastric acid secretion. Omeprazole should be taken as directed and Proquin XR should be taken with a main meal of the day, preferably the evening meal..

Phenytoin

Altered serum levels of phenytoin (increased and decreased) have been reported in patients receiving concomitant ciprofloxacin.

Probenecid

Probenecid interferes with renal tubular secretion of ciprofloxacin and produces an increase in the level of ciprofloxacin in serum.

Theophylline

As with some other quinolones, concurrent administration of ciprofloxacin with theophylline may lead to elevated serum concentrations of theophylline and prolongation of its elimination half-life. This may result in increased risk of theophylline-related adverse reactions. If concomitant use cannot be avoided, serum levels of theophylline should be monitored and dosage adjustments made as appropriate.

Warfarin

Quinolones have been reported to enhance the effects of the oral anticoagulant warfarin or its derivatives. When these products are administered concomitantly, prothrombin time or other suitable coagulation tests should be monitored.

Toxicity reversible renal toxicity, hypoactivity and cyanosis
Organisms Affected Not Available
Chemical IUPAC Name 1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-yl-1H-quinoline-3-carboxylicacid
Chemical Formula C17H18FN3O3
Molecular Weight 331.342 g/mol
Smiles String C1CC1N2C=C(C(=O)C3=CC(=C(C=C32)N4CCNCC4)F)C(=O)O
Melting Point 318-320°C
Water Solubility 1.1 mg/L
State Solid
LogP/Hphobicity 1.335
Isoelectric Point Not Available
Biotransformation hepatic
Half Life 4 hours
Protein Binding [%] 20 to 40%
RxList Link RXlist
Sponsored links
Drug Reference http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/cip1082.shtml
http://www.drugs.com/cons/Ciprofloxacin.html
http://www.rxlist.com/cgi/generic/cipro.htm
Drug Type Approved Drug
Accession No APRD00424
CAS Registry Number 85721-33-1
KEGG Compound ID C05349
PubChem ID SID:192835
PharmGKB ID PA449009
SwissProt ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] 2248439

Home | About | Cancers | Treatment | Medications
Copyright onconews.org 2005.
All Rights Reserved.
Google
 
Web onconews.org