|
|
|
|
|
Cinnarizine
drug data and news
Cinnarizine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
|
| Generic name | Cinnarizine | ||
| Brand Names/Synonyms | 516 MD; Abitrate; Aplactan; Aplexal; Apotomin; Artate; Carecin; Cerebolan; Cerepar; Chlorophenoxyisobutyricacidethylester; Cinaperazine; Cinazyn; Cinnacet; Cinnageron; Cinnarizine; Cinnarizine Stugeron; Clofibrate; Corathiem; Denapol; Dimitron; Dimitronal; Eglen; Folcodal; Giganten; Glanil; Hilactan; Ixertol; Katoseran; Labyrin; Lazeta; Marisan; Midronal; Mitronal; Olamin; Processine; R 1575; R 516; Sedatromin; Sepan; Siptazin; Spaderizine; Stugeron; Stutgeron; Stutgin; Toliman | ||
| Indication | For the treatment of vertigo/meniere's disease, nausea and vomiting, motion sickness and also useful for vestibular symptoms of other origins. | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Used in the treatment of motion sickness, vertigo and migraine. Cinnarizine is an antihistamine and a calcium channel blocker. Histamines mediate a number of activities such as contraction of smooth muscle of the airways and gastrointestinal tract, vasodilatation, cardiac stimulation, secretion of gastric acid, promotion of interleukin release and chemotaxis of eosinophils and mast cells. Competitive antagonists at histamine H1 receptors may be divided into first (sedating) and second (non-sedating) generation agents. Some, such as Cinnarizine also block muscarinic acetylcholine receptors and are used as anti-emetic agents. Cinnarizine through its calcium channel blocking ability also inhibits stimulation of the vestibular system. | ||
| Mechanism Of Action | Binds to the Histamine H1 receptor and to muscarinic acetylcholine receptors. Cinnarizine also inhibits contractions of vascular smooth muscle cells by blocking L type calcium channels. Cinnarizine has also been implicated in binding to dopamine D2 receptors. | ||
| Cinnarizine News (When available) |
How can I prevent my children from becoming travel sick? Mar 2, 2006 | ||
| Dosage Forms | Not Available | ||
| Drug_Category | anti-emetics; antivertigo ATC:N07CA02 | ||
| Absorption | Not Available | ||
| Interactions | Not Available | ||
| Toxicity | Not Available | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 1-benzhydryl-4-cinnamyl-piperazine | ||
| Chemical Formula | C26H28N2 | ||
| Molecular Weight | 368.514 g/mol | ||
| Smiles String | C1CN(CCN1CC=CC2=CC=CC=C2)C(C3=CC=CC=C3)C4=CC=CC=C4 | ||
| Melting Point | Not Available | ||
| Water Solubility | 750 mg/L | ||
| State | Solid | ||
| LogP/Hphobicity | 5.63 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Not Available | ||
| Half Life | Not Available | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | Not Available>RXlist | ||
| Sponsored links | |||
| Drug Reference | Not Available | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00332 | ||
| CAS Registry Number | 298-57-7 | ||
| KEGG Compound ID | C12725 | ||
| PubChem ID | SID:360170 | ||
| PharmGKB ID | Not Available | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | Not Available |
|
Home | About | Cancers | Treatment | Medications Copyright onconews.org 2005. All Rights Reserved. |