Cimetidine drug data and news

Cimetidine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name Cimetidine
Brand Names/Synonyms Acibilin; Acinil; CIMETIDINE A/AB; Carbamazapine; Cimal; Cimetag; Cimetidine; Cimetidine Hcl; Cimetum; Dyspamet; Edalene; Eureceptor; FPF 1002; Gastromet; Peptol; Tagamet; Tagamet Hb; Tagamet Hb 200; Tametin; Tratul; Ulcedin; Ulcedine; Ulcerfen; Ulcimet; Ulcofalk; Ulcomedina; Ulcomet; Ulhys
Indication For the treatment and the management of acid-reflux disorders (GERD), peptic ulcer disease, heartburn, and acid indigestion
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Description Not Available
Pharmacology Cimetidine is a histamine H2-receptor antagonist. It reduces basal and nocturnal gastric acid secretion and a reduction in gastric volume, acidity, and amount of gastric acid released in response to stimuli including food, caffeine, insulin, betazole, or pentagastrin. It is used to treat gastrointestinal disorders such as gastric or duodenal ulcer, gastroesophageal reflux disease, and pathological hypersecretory conditions. Cimetidine inhibits many of the isoenzymes of the hepatic CYP450 enzyme system. Other actions of Cimetidine include an increase in gastric bacterial flora such as nitrate-reducing organisms.
Mechanism Of Action Cimetidine binds to an H2-receptor located on the basolateral membrane of the gastric parietal cell, blocking histamine effects. This competitive inhibition results in reduced gastric acid secretion and a reduction in gastric volume and acidity.
Cimetidine News
(When available)

Oscient Pharmaceuticals Reports Financial Results for Fourth ...  06 Mar 2006
No significant drug-drug interactions were seen with theophylline, digoxin, oral contraceptives, cimetidine, omeprazole, and warfarin, although patients ... - Genetic Engineering News,

Common practice of prescribing H2 blockers to treat acid reflux in ...  Feb 24, 2006
The cause of the disorder is unknown. Common H2 blockers are cimetidine (Tagamet), famotidine (Pepcid), ranitidine (Zantac), and nizatidine (Axid). ... - News-Medical.net,

H 2 Blockers in Preemies Raise Necrotizing Enterocolitis Risk  Feb 9, 2006
H 2 blockers such as Tagamet (cimetidine), Pepcid (famotidine), Zantac (ranitidine), and Axid (nizatidine) are commonly given to neonates to treat or prevent ... - MedPage Today,

Basic Science Investigation  Feb 9, 2006
Cimetidine, diclofenac, and miconazole, known inhibitors of CYP450 2EI, were tested for the ability to inhibit defluorination of 18 F-FCWAY in rat liver ... - Journal of Nuclear Medicine

H 2 Blockers in Preemies Raise Necrotizing Enterocolitis Risk  09 Feb 2006
H 2 blockers such as Tagamet (cimetidine), Pepcid (famotidine), Zantac (ranitidine), and Axid (nizatidine) are commonly given to neonates to treat or prevent ... - MedPage Today,

Common Reflux Treatment Linked to Life Threatening Bowel Infection ...  09 Feb 2006
The cause of the disorder is unknown. Common H2 blockers are cimetidine (Tagamet), famotidine (Pepcid), ranitidine (Zantac), and nizatidine (Axid). ... - Kansas City infoZine,

Will Cimetidine Hurt the Foal?  Jan 10, 2006
This column features readers' questions with answers by members of the American Association of Equine Practitioners or their designates. ... - TheHorse.com,

FDA Accepts for Filing Oscient Pharmaceuticals' Supplemental New ...  Jan 20, 2006
No significant drug-drug interactions were seen with theophylline, digoxin, oral contraceptives, cimetidine, omeprazole, and warfarin, although patients ... - Genetic Engineering News,

Reduce platelet aggregation, blood clotting, inflammation, nervous ...  Jan 12, 2006
...on the central nervous system, such as levodopa prescribed for Parkinson’s disease, alprazolam (Xanor) a tranquiliser, and cimetidine (Tagamet), prescribed ... - Health24.com,

I’ma man with big breasts  Jan 7, 2006
Drugs and medications like cimetidine (used for ulcers), carbamizepine (used for epilepsy), and some anti depressants, water pills like spirolactolone, anti-TB ... - The Monitor, Uganda,

Cisplatin Nephrotoxicity Is Critically Mediated via the Human ...  Dec 9, 2005
...incubation with cis-platin induced apoptosis, which was completely suppressed by contemporaneous incubation with the hOCT2 substrate cimetidine (100 µmol/L ... - Am J Pathology (subscription)

Sir James to step down as chancellor  Dec 9, 2005
The prize was awarded to Sir James for his development of beta-blocker drugs such as propranolol for cardio- vascular treatments, and cimetidine for non-toxic ... - Evening Telegraph,

New Data on FACTIVE(R) Tablets and Ramoplanin Presented at the ...  Dec 9, 2005
No significant drug-drug interactions were seen with theophylline, digoxin, oral contraceptives, cimetidine, omeprazole, and warfarin, although patients ... - Genetic Engineering News,

Treating nails when fungus, yeast invade  Nov 8, 2005
...efficiency buzz. Another bad combination is Lamisil with certain antidepressants or the acid blocker Cimetidine. Sporanox comes ... - Newsday,

Some ways to get rid of those bothersome warts  Nov 22, 2005
...weeks, have been shown to be helpful. Oral retinoids or cimetidine have helped some people. Imiquimod (brand name Aldara) is the ... - Newsday,

Holiday Treats Present Temptations and Challenges for Children ...  Nov 22, 2005
Examples include nizatidine (Axid(R) OS), ranitidine, famotidine and cimetidine(i). -- Find a treatment that is easy for the child to take - large pills or ... - PR Newswire (press release),

Holidays Present Challenges for Children With GERD  Nov 23, 2005
...is called H2-blockers. Examples include nizatidine (Axid® OS), ranitidine, famotidine and cimetidine. -- Find a treatment that ... - EndoNurse,

Holiday Treats Present Temptations and Challenges for Children ...  Nov 22, 2005
Examples include nizatidine (Axid® OS), ranitidine, famotidine and cimetidine(i). -- Find a treatment that is easy for the child to take - large pills or harsh ... - Market Wire (press release)

Oscient Pharmaceuticals to Present Clinical Data on FACTIVE(R) ...  31 Oct 2005
No significant drug-drug interactions were seen with theophylline, digoxin, oral contraceptives, cimetidine, omeprazole, and warfarin, although patients ... - Genetic Engineering News,

DR GARETH: IS TATTOO TOO RISKY FOR ME  Oct 29, 2005
ATAGAMET (also known as cimetidine) is available by prescription and over-the-counter and is commonly used to treat the symptoms of reflux oesosophigitis ... - Glasgow Sunday Mail,

Ulcers mostly caused by bacteria, not stress  Oct 24, 2005
...treated with a combination of antibiotics (to kill the bacteria) and drugs that reduce stomach acid (H2 blockers such as cimetidine, ranitidine, famotidine and ... - Inside Bay Area,

Who ate all the prize?  Oct 8, 2005
...and treating them is big business: 1988 saw Sir James Black awarded the Prize for Physiology or Medicine in part for his discovery of cimetidine, the first H2 ... - Ars Technica

My brush with Nobelity  Oct 11, 2005
...add), to antacids, to psychotherapy. In 1976 cimetidine came along. All were designed to reduce acid. By chance Marshall had noted ... - AustralianDoctor.com (subscription),

Bacteria Linked To Heart Risk  Oct 7, 2005
...clarithromycin, tetracycline, and metronidazole--along with an acid-lowering medicine such as Pepto-Bismol, ranitidine, cimetidine, famotidine, omprazole ... - Saturday Evening Post,

Vitamin B-12 supplements are insurance  Oct 6, 2005
...supplementation. These drugs include H2 blockers such as cimetidine (Tagamet) and proton pump inhibitors such as omeprazole (Prilosec, Losec). ... - Biloxi Sun Herald,

Off-Label Drug Use  Oct 14, 2005
That drug as well as cimetidine (Tagamet), ranitidine (Zantac), famotidine (Pepcid), and sucralfate (Cara-fate) were (and in the case of all but Gastro-Gard ... - TheHorse.com,

My brush with Nobelity  11 Oct 2005
...add), to antacids, to psychotherapy. In 1976 cimetidine came along. All were designed to reduce acid. By chance Marshall had noted ... - AustralianDoctor.com (subscription),

B12 supplementation may not be necessary  11 Oct 2005
...supplementation. These drugs include H2 blockers such as cimetidine (Tagamet) and proton pump inhibitors such as omeprazole (Prilosec, Losec). ... - Contra Costa Times,

Who ate all the prize?  Oct 8, 2005
...and treating them is big business: 1988 saw Sir James Black awarded the Prize for Physiology or Medicine in part for his discovery of cimetidine, the first H2 ... - Ars Technica

Counter intelligence: Experts offer advice on using non ...  Sep 27, 2005
Another common OTC with many drug-to-drug reactions is cimetidine, found in medicines like Tagamet, says Krimko. "Serum concentrations ... - Asbury Park Press,

Bacteria Linked To Heart Risk  Oct 7, 2005
...clarithromycin, tetracycline, and metronidazole--along with an acid-lowering medicine such as Pepto-Bismol, ranitidine, cimetidine, famotidine, omprazole ... - Saturday Evening Post,

Clinical Data on FACTIVE(R) Tablets for ABS and AECB Presented at ...  Oct 7, 2005
No significant drug-drug interactions were seen with theophylline, digoxin, oral contraceptives, cimetidine, omeprazole, and warfarin, although patients ... - Genetic Engineering News,

EFNS: Skin Patch Eases Early and Late Parkinson's Symptoms  Sep 19, 2005
No drug-drug interactions with levodopa, carbidopa, cimetidine or domperidone have been observed, according to Schwarz Pharma AG in Manheim, Germany. - MedPage Today,

Locked Into Place  Sep 11, 2005
...a varied drug therapy of lactated Ringer's solution, dimethyl sulfoxide (DMSO), erythromycin phosphate, rifampin, flunixin meglumine (Banamine), and cimetidine ... - TheHorse.com,

Nurse leads mission to Haiti  Sep 22, 2005
...items: n Ibuprofen (Advil, Motrin), adult and children’s. n Cimetidine (Tagamet), Ranitidine (Zantac) or Famotidine (Pepcid). - Quad City Times,

Cheap branded drugs soon available in Botika ng Bayan  Sep 9, 2005
Drugs developed by GSK that are in the list include ranitidine (to treat symptoms of heartburn), cimetidine (for ulcer), albendazole (to treat infections ... - INQ7 Interactive, Inc.,

LAMINITIS: A HORSE'S WORST NIGHTMARE  Sep 1, 2005
...ulcers. As a precaution, some kind of acid-blocking drug (ie, Zantac, Cimetidine) is generally used to counter this problem. Foolish ... - Mother Earth News,

Erectile dysfunction  Aug 31, 2005
...these include drugs taken for high blood pressure, anti-depressants, anti-histamines, tranquillisers, appetite suppressants, and the ulcer drug cimetidine. ... - Health24.com,

Impotence-Erectile Dysfunction  Aug 27, 2005
These include high blood pressure drugs, antihistamines, antidepressants, tranquilizers, appetite suppressants, and cimetidine (an ulcer drug). ... - Bella Online

NEW YORK MEDICATION RULES TO CHANGE  Aug 10, 2005
...instrumentation allows for greater specificity as to the timing of administrations such as removing sulfa expectorants, omeprazole, cimetidine, ranitidine, and ... - Harnesslink,

Allergy skin tests: Identify the sources of your sneezing  Jul 11, 2005
2. Over-the-counter antihistamines (Benadryl, Chlor-Trimeton, others). 4. Heartburn medications, such as cimetidine (Tagamet) and ranitidine (Zantac). ... - Afternoon Dispatch & Courier <**results**>

Allergy skin tests: Identify the sources of your sneezing  11 Jul 2005
2. Over-the-counter antihistamines (Benadryl, Chlor-Trimeton, others). 4. Heartburn medications, such as cimetidine (Tagamet) and ranitidine (Zantac). ... - Afternoon Dispatch & Courier

Erectile Drugs, Used With Care, Help  Jun 28, 2005
...alpha blockers for hypertension; protease inhibitors used in AIDS treatment; the antifungals ketoconazole and itraconazole; and the acid reducer cimetidine. ... - The Ledger

LAMINITIS: A HORSE'S WORST NIGHTMARE  Jun 28, 2005
...ulcers. As a precaution, some kind of acid-blocking drug (ie, Zantac, Cimetidine) is generally used to counter this problem. Foolish ... - Mother Earth News

Pharma firm’s ‘Value Health’ expands medicine discounts  Jun 19, 2005
...of a discount of up to 30 percent on antibiotic brands from Eli Lilly; antibiotic co-trimoxazole; anti-ulcerant ranitidine and cimetidine; cough preparation ... - Manila Bulletin

Oscient Pharmaceuticals Achieves Primary Endpoint in Phase III ...  Jun 6, 2005
No significant drug-drug interactions were seen with theophylline, digoxin, oral contraceptives, cimetidine, omeprazole, and warfarin, although patients ... - Business Wire (press release),

Dosage Forms Tablets; Oral solution
Drug_Category Analgesics; Anti-ulcer Agents; Adjuvants; Histamine Antagonists; ATC:A02BA01
Absorption Rapid 60-70%
Interactions -->Interactions for Cimetidine:

Tagamet, apparently through an effect on certain microsomal enzyme systems, has been reported to reduce the hepatic metabolism of warfarin-type anticoagulants, phenytoin, propranolol, nifedipine, chlordiazepoxide, diazepam, certain tricyclic antidepressants, lidocaine, theophylline and metronidazole, thereby delaying elimination and increasing blood levels of these drugs.

Clinically significant effects have been reported with the warfarin anticoagulants; therefore, close monitoring of prothrombin time is recommended, and adjustment of the anticoagulant dose may be necessary when Tagamet is administered concomitantly. Interaction with phenytoin, lidocaine and theophylline has also been reported to produce adverse clinical effects.

However, a crossover study in healthy subjects receiving either Tagamet 300 mg q.i.d. or 800 mg h.s. concomitantly with a 300 mg b.i.d. dosage of theophylline (Theo-Dur®, Key Pharmaceuticals, Inc.) demonstrated less alteration in steady-state theophylline peak serum levels with the 800 mg h.s. regimen, particularly in subjects aged 54 years and older. Data beyond 10 days are not available. (Note: All patients receiving theophylline should be monitored appropriately, regardless of concomitant drug therapy.)

Dosage of the drugs mentioned above and other similarly metabolized drugs, particularly those of low therapeutic ratio or in patients with renal and/or hepatic impairment, may require adjustment when starting or stopping concomitantly administered Tagamet to maintain optimum therapeutic blood levels.

Alteration of pH may affect absorption of certain drugs (e.g., ketoconazole). If these products are needed, they should be given at least 2 hours before cimetidine administration.

Additional clinical experience may reveal other drugs affected by the concomitant administration of Tagamet.

 

Toxicity nausea, vomiting, diarrhea, increased saliva production, difficulty breathing, and a fast heartbeat.
Organisms Affected Humans and other mammals
Chemical IUPAC Name 1-cyano-2-methyl-3-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethyl]guanidine
Chemical Formula C10H16N6S
Molecular Weight 252.34 g/mol
Smiles String CC1=C(N=CN1)CSCCNC(=NC)NC#N
Melting Point 142 °C
Water Solubility 0.5 g/100 mL
State Solid
LogP/Hphobicity 0.879
Isoelectric Point 6.8
Biotransformation Hepatic
Half Life 2 hours
Protein Binding [%] 15-20%
RxList Link RXlist
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Drug Reference http://www.drugs.com/cons/Cimetidine.html
http://www.rxlist.com/cgi/generic/cimet.htm
Drug Type Approved Drug
Accession No APRD00568
CAS Registry Number 51481-61-9
KEGG Compound ID C06952
PubChem ID SID:180968
PharmGKB ID PA449001
SwissProt ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] 749494

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