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Chlorzoxazone
drug data and news
Chlorzoxazone drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Chlorzoxazone | ||
| Brand Names/Synonyms | Biomioran; Chloroxazone; Chlorzoxane; Chlorzoxazon; Chlorzoxazone; EZE-DS; Escoflex; Flexazone; Mioran; Miotran; Myoflexin; Myoflexine; Neoflex; Paraflex; Parafon Forte Dsc; Pathorysin; Relaxazone; Remular; Remular-S; Solaxin; Strifon Forte Dsc; Usaf Ma-10 | ||
| Indication | For the relief of discomfort associated with acute painful musculoskeletal conditions. | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Chlorzoxazone, a synthetic compound, inhibits antigen-induced bronchospasms and, hence, is used to treat asthma and allergic rhinitis. Chlorzoxazone is used as an ophthalmic solution to treat conjunctivitis and is taken orally to treat systemic mastocytosis and ulcerative colitis. Chlorzoxazone is also a centrally-acting agent for painful musculoskeletal conditions. Data available from animal experiments as well as human study indicate that chlorzoxazone acts primarily at the level of the spinal cord and subcortical areas of the brain where it inhibits multisynaptic reflex a.c. involved in producing and maintaining skeletal muscle spasm of varied etiology. The clinical result is a reduction of the skeletal muscle spasm with relief of pain and increased mobility of the involved muscles. | ||
| Mechanism Of Action | Chlorzoxazone inhibits degranulation of mast cells, subsequently preventing the release of histamine and slow-reacting substance of anaphylaxis (SRS-A), mediators of type I allergic reactions. Chlorzoxazone also may reduce the release of inflammatory leukotrienes. Chlorzoxazone may act by inhibiting calcium influx. | ||
| Chlorzoxazone News (When available) |
Merrimack County Superior Court Log Sep 23, 2005 The Blather guide to Drool Apr 16, 2005 | ||
| Dosage Forms | Tablet (500 mg) | ||
| Drug_Category | Muscle Relaxants, Central; ATC:M03BB03 | ||
| Absorption | Not Available | ||
| Interactions | Interactions for Chlorzoxazone: The concomitant use of alcohol or other central nervous system depressants may have an additive effect. | ||
| Toxicity | Oral, mouse: LD50 = 440 mg/kg; Oral, rat: LD50 = 763 mg/kg. Symptoms of overdose include diarrhea, dizziness, drowsiness, headache, light-headedness, nausea, and vomiting. | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 5-chloro-3H-benzooxazol-2-one | ||
| Chemical Formula | C7H4ClNO2 | ||
| Molecular Weight | 169.565 g/mol | ||
| Smiles String | C1=CC2=C(C=C1Cl)NC(=O)O2 | ||
| Melting Point | 191.5 °C | ||
| Water Solubility | 0.1 g/100mL | ||
| State | Solid | ||
| LogP/Hphobicity | 1.659 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Chlorzoxazone is rapidly metabolized in the liver and is excreted in the urine, primarily in a conjugated form as the glucuronide. | ||
| Half Life | Not Available | ||
| Protein Binding [%] | 13-18% | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Chlorzoxazone.html http://www.rxlist.com/cgi/generic2/chlorzox.htm http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/par1317.shtml | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00308 | ||
| CAS Registry Number | 95-25-0 | ||
| KEGG Compound ID | C07931 | ||
| PubChem ID | SID:63843 | ||
| PharmGKB ID | PA448971 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | Not Available |
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